Phase Ii randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases

Background and purpose: Chloroquine (CLQ), an antimalarial drug, has a lysosomotropic effect associated with increased radiationsensibility, which is mediated by the leakage of hydrolytic enzymes, increased apoptosis, autophagy and increased oxidative stress in vitro. In this phase II study, we eval...

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Detalles Bibliográficos
Autor Principal: Rojas Puentes, Luis Leonardo; Arce Salinas, Claudia; Arrieta, Óscar; Crismatt, Alejando; Dorantes Gallareta, Yusmiren; Gamboa Vignolle, Carlos; González Pinedo, Marcelino; Núñez Gómez, Rodrigo; Ortega Gómez, Alette
Formato: Artículo (Article)
Lenguaje:Desconocido (Unknown)
Publicado: Radiation Oncology; Vol. 8 2013
Materias:
Acceso en línea:http://babel.banrepcultural.org/cdm/ref/collection/p17054coll23/id/707