Bayesian network and artificial intelligence to predict cardiovascular events in chronic kidney disease patients = Uso de inteligencia artificial y estadística bayesiana para predecir un evento cardiovascular en pacientes con enfermedad renal crónica

Background: Current scores do not adequately predict cardiovascular risk in patients with chronic kidney disease who are at a very high CV risk in short and medium term. Aim: The aim of our analysis was to create a Bayesian network to predict the 2-year occurrence of a cardiovascular event in patie...

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Autor Principal: Montoya Torres, Lina Marcela; Ducher, Michel; Florens, Nans; Fauvel, Jean Pierre
Formato: Artículo (Article)
Lenguaje:Desconocido (Unknown)
Publicado: Annales de cardiologie Disponible en (www.sciencedirect.com) 2019
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Acceso en línea:http://babel.banrepcultural.org/cdm/ref/collection/p17054coll23/id/1139
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spelling ir-p17054coll23-11392020-09-29 Bayesian network and artificial intelligence to predict cardiovascular events in chronic kidney disease patients = Uso de inteligencia artificial y estadística bayesiana para predecir un evento cardiovascular en pacientes con enfermedad renal crónica Montoya Torres, Lina Marcela; Ducher, Michel; Florens, Nans; Fauvel, Jean Pierre Background: Current scores do not adequately predict cardiovascular risk in patients with chronic kidney disease who are at a very high CV risk in short and medium term. Aim: The aim of our analysis was to create a Bayesian network to predict the 2-year occurrence of a cardiovascular event in patients with chronic kidney disease. Methods and results: The data originated from the observational and prospective Photo-Graphe V3 cohort. Sixty-two nephrologists in 20 French regions included 1144 non-dialysed patients with chronic kidney disease. Seven hundred and thirty patients with known medical status at 2 years were analysed. An initial Bayesian model was first built using 26 variables related to the characteristics of the patients, their medical background, and treatments. A cardiovascular event (heart failure, acute coronary syndrome, transient ischemic attack, stroke or cardiovascular death) occurred in 20.0% of the patients after two years of follow-up. The model was first optimized using synthetic data (created from the original database) to increase its reliability. The number of variables was then reduced using the 13 most informative variables to increase its clinical applicability. The10-fold cross validation showed that the optimized clinical model with 13 variables had an area under the ROC curve of 0.90+0.02, a sensitivity of 82.5+5.9%, a specificity of 80.6+5.1%, a predictive positive value of 81.2+3.4% and a negative predictive value of 82.5+4.4%. The percentage of misclassified subjects was 18.4+2.6%. Conclusion: Using artificial intelligence methods, a new clinical tool to predict cardiovascular events in patients with chronic kidney disease is proposed. Chronic kidney disease; Hypertension; Renal failure; Cardiovascular risk; Prediction; Bayesian network; Artificial intelligence; Inteligencia artificial; Enfermedad renal crónica; Riesgo cardiovascular; Factores predictivos; Estadística bayesiana Tecnología; Tecnología / Ciencias médicas Medicina; Tecnología / Ciencias médicas Medicina / Enfermedades 2019 Annales de cardiologie Disponible en (www.sciencedirect.com) PDF Artículo ENG - Inglés Colombia Colfuturo © Derechos reservados del autor http://babel.banrepcultural.org/cdm/ref/collection/p17054coll23/id/1139
institution Biblioteca Virtual Banco de la República - Colecciones digitales
collection Custom
language Desconocido (Unknown)
topic Chronic kidney disease; Hypertension; Renal failure; Cardiovascular risk; Prediction; Bayesian network; Artificial intelligence; Inteligencia artificial; Enfermedad renal crónica; Riesgo cardiovascular; Factores predictivos; Estadística bayesiana
Tecnología; Tecnología / Ciencias médicas Medicina; Tecnología / Ciencias médicas Medicina / Enfermedades
spellingShingle Chronic kidney disease; Hypertension; Renal failure; Cardiovascular risk; Prediction; Bayesian network; Artificial intelligence; Inteligencia artificial; Enfermedad renal crónica; Riesgo cardiovascular; Factores predictivos; Estadística bayesiana
Tecnología; Tecnología / Ciencias médicas Medicina; Tecnología / Ciencias médicas Medicina / Enfermedades
Montoya Torres, Lina Marcela; Ducher, Michel; Florens, Nans; Fauvel, Jean Pierre
Bayesian network and artificial intelligence to predict cardiovascular events in chronic kidney disease patients = Uso de inteligencia artificial y estadística bayesiana para predecir un evento cardiovascular en pacientes con enfermedad renal crónica
description Background: Current scores do not adequately predict cardiovascular risk in patients with chronic kidney disease who are at a very high CV risk in short and medium term. Aim: The aim of our analysis was to create a Bayesian network to predict the 2-year occurrence of a cardiovascular event in patients with chronic kidney disease. Methods and results: The data originated from the observational and prospective Photo-Graphe V3 cohort. Sixty-two nephrologists in 20 French regions included 1144 non-dialysed patients with chronic kidney disease. Seven hundred and thirty patients with known medical status at 2 years were analysed. An initial Bayesian model was first built using 26 variables related to the characteristics of the patients, their medical background, and treatments. A cardiovascular event (heart failure, acute coronary syndrome, transient ischemic attack, stroke or cardiovascular death) occurred in 20.0% of the patients after two years of follow-up. The model was first optimized using synthetic data (created from the original database) to increase its reliability. The number of variables was then reduced using the 13 most informative variables to increase its clinical applicability. The10-fold cross validation showed that the optimized clinical model with 13 variables had an area under the ROC curve of 0.90+0.02, a sensitivity of 82.5+5.9%, a specificity of 80.6+5.1%, a predictive positive value of 81.2+3.4% and a negative predictive value of 82.5+4.4%. The percentage of misclassified subjects was 18.4+2.6%. Conclusion: Using artificial intelligence methods, a new clinical tool to predict cardiovascular events in patients with chronic kidney disease is proposed.
format Artículo (Article)
author Montoya Torres, Lina Marcela; Ducher, Michel; Florens, Nans; Fauvel, Jean Pierre
author_facet Montoya Torres, Lina Marcela; Ducher, Michel; Florens, Nans; Fauvel, Jean Pierre
author_sort Montoya Torres, Lina Marcela; Ducher, Michel; Florens, Nans; Fauvel, Jean Pierre
title Bayesian network and artificial intelligence to predict cardiovascular events in chronic kidney disease patients = Uso de inteligencia artificial y estadística bayesiana para predecir un evento cardiovascular en pacientes con enfermedad renal crónica
title_short Bayesian network and artificial intelligence to predict cardiovascular events in chronic kidney disease patients = Uso de inteligencia artificial y estadística bayesiana para predecir un evento cardiovascular en pacientes con enfermedad renal crónica
title_full Bayesian network and artificial intelligence to predict cardiovascular events in chronic kidney disease patients = Uso de inteligencia artificial y estadística bayesiana para predecir un evento cardiovascular en pacientes con enfermedad renal crónica
title_fullStr Bayesian network and artificial intelligence to predict cardiovascular events in chronic kidney disease patients = Uso de inteligencia artificial y estadística bayesiana para predecir un evento cardiovascular en pacientes con enfermedad renal crónica
title_full_unstemmed Bayesian network and artificial intelligence to predict cardiovascular events in chronic kidney disease patients = Uso de inteligencia artificial y estadística bayesiana para predecir un evento cardiovascular en pacientes con enfermedad renal crónica
title_sort bayesian network and artificial intelligence to predict cardiovascular events in chronic kidney disease patients = uso de inteligencia artificial y estadística bayesiana para predecir un evento cardiovascular en pacientes con enfermedad renal crónica
publisher Annales de cardiologie Disponible en (www.sciencedirect.com)
publishDate 2019
url http://babel.banrepcultural.org/cdm/ref/collection/p17054coll23/id/1139
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score 12,131701