Deep brain stimulation modeling for several anatomical and electrical considerations

Deep Brain Stimulation (DBS) is a clinical treatment for Parkinson disease symptoms. DBS consists in the implantation of a stimulation electrode into the Subthalamic nucleus (STN) for the excitation of specific regions inside the STN. The stimulation potential has a few parameters that should be adj...

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Autores Principales: Torres-Valencia, Cristian Alejandro, Daza-Santacoloma, Genaro, Álvarez-López, Mauricio Alexander, Orozco-Gutiérrez, Álvaro Ángel
Formato: Artículo (Article)
Lenguaje:Español (Spanish)
Publicado: Universidad Santo Tomás. Seccional Bucaramanga 2014
Materias:
id ir-11634-8362
recordtype dspace
institution Universidad Santo Tomas
collection DSpace
language Español (Spanish)
topic Deep Brain Stimulation, electric propagation, finite element method, Laplace equation, Parkinson disease, Poisson equation, subthalamic nucleus
Ecuación de Laplace; ecuación de Poisson; enfermedad de Parkinson; estimulación cerebral profunda; método de elementos finitos; núcleo subtalámico; propagación eléctrica
spellingShingle Deep Brain Stimulation, electric propagation, finite element method, Laplace equation, Parkinson disease, Poisson equation, subthalamic nucleus
Ecuación de Laplace; ecuación de Poisson; enfermedad de Parkinson; estimulación cerebral profunda; método de elementos finitos; núcleo subtalámico; propagación eléctrica
Torres-Valencia, Cristian Alejandro
Daza-Santacoloma, Genaro
Álvarez-López, Mauricio Alexander
Orozco-Gutiérrez, Álvaro Ángel
Deep brain stimulation modeling for several anatomical and electrical considerations
description Deep Brain Stimulation (DBS) is a clinical treatment for Parkinson disease symptoms. DBS consists in the implantation of a stimulation electrode into the Subthalamic nucleus (STN) for the excitation of specific regions inside the STN. The stimulation potential has a few parameters that should be adjusted in order to achieve the desired treatment effect. The adjust is performed by the neurologist in several sessions with the patients and is not an exact procedure. In recent years there have been several works on the construction of propagation models of DBS, including head geometries and medium properties in order to visualize the possible effects of DBS while the stimulation parameters are adjusted. This work presents the construction of propagation models using the Finite Element Method (FEM) for the solution of Laplace or Poisson equations that govern the propagation phenomena. By the construction of these models, the shape and magnitude of the electric propagation inside the objective structures can be obtained.
format Artículo (Article)
author Torres-Valencia, Cristian Alejandro
Daza-Santacoloma, Genaro
Álvarez-López, Mauricio Alexander
Orozco-Gutiérrez, Álvaro Ángel
author_facet Torres-Valencia, Cristian Alejandro
Daza-Santacoloma, Genaro
Álvarez-López, Mauricio Alexander
Orozco-Gutiérrez, Álvaro Ángel
author_sort Torres-Valencia, Cristian Alejandro
title Deep brain stimulation modeling for several anatomical and electrical considerations
title_short Deep brain stimulation modeling for several anatomical and electrical considerations
title_full Deep brain stimulation modeling for several anatomical and electrical considerations
title_fullStr Deep brain stimulation modeling for several anatomical and electrical considerations
title_full_unstemmed Deep brain stimulation modeling for several anatomical and electrical considerations
title_sort deep brain stimulation modeling for several anatomical and electrical considerations
publisher Universidad Santo Tomás. Seccional Bucaramanga
publishDate 2014
_version_ 1712105523555336192
spelling ir-11634-83622019-11-14T21:32:39Z Deep brain stimulation modeling for several anatomical and electrical considerations Modelos de estimulación cerebral profunda para diferentes consideraciones anatómicas y eléctricas Torres-Valencia, Cristian Alejandro Daza-Santacoloma, Genaro Álvarez-López, Mauricio Alexander Orozco-Gutiérrez, Álvaro Ángel Deep Brain Stimulation, electric propagation, finite element method, Laplace equation, Parkinson disease, Poisson equation, subthalamic nucleus Ecuación de Laplace; ecuación de Poisson; enfermedad de Parkinson; estimulación cerebral profunda; método de elementos finitos; núcleo subtalámico; propagación eléctrica Deep Brain Stimulation (DBS) is a clinical treatment for Parkinson disease symptoms. DBS consists in the implantation of a stimulation electrode into the Subthalamic nucleus (STN) for the excitation of specific regions inside the STN. The stimulation potential has a few parameters that should be adjusted in order to achieve the desired treatment effect. The adjust is performed by the neurologist in several sessions with the patients and is not an exact procedure. In recent years there have been several works on the construction of propagation models of DBS, including head geometries and medium properties in order to visualize the possible effects of DBS while the stimulation parameters are adjusted. This work presents the construction of propagation models using the Finite Element Method (FEM) for the solution of Laplace or Poisson equations that govern the propagation phenomena. By the construction of these models, the shape and magnitude of the electric propagation inside the objective structures can be obtained. La estimulación cerebral profunda (DBS) es una  terapia  quirúrgica  validada  para  el  tratamiento de los  síntomas  asociados  con  la  enfermedad  de  Parkinson. Consiste en la implantación de un electrodo de estimulación generalmente en la región del núcleo subtalámico (STN), con el cual se excitan regiones específicas a partir de un potencial eléctrico con ciertos parámetros específicos. El ajuste de los parámetros de estimulación es un proceso realizado por parte del neurólogo y puede tardar varios meses hasta alcanzar los resultados deseados. Es por esto que en años recientes se ha estudiado la construcción de modelos de propagación eléctrica de las estructuras objetivo de la DBS con el fin de visualizar los posibles resultados de la distribución de campo eléctrico y la activación del tejido cerebral que sirven como guía  para  el  ajuste  de  los parámetros  de  estimulación, optimizando el procedimiento de configuración. En este trabajo  se  presenta  la  comparación  de  modelos  de  simulación que incluyen la definición de geometrías complejas  representando  diferentes  estructuras  cerebrales con propiedades de diferentes tejidos, con los cuales se obtienen los patrones de propagación eléctrica cerebral por medio del método de elementos finitos (FEM) aplicado a la solución de las ecuaciones de Laplace y Poisson. 2014-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://revistas.ustabuca.edu.co/index.php/ITECKNE/article/view/723 10.15332/iteckne.v11i2.723 spa http://revistas.ustabuca.edu.co/index.php/ITECKNE/article/view/723/569 /*ref*/P. Limousin, P. Pollak, A. Benazzouz, D. Hoffmann, J. F. Le Bas, E. Broussolle, J. E. Perret, and A. L. Benabid, “Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation.” Lancet, vol. 345, no. 8942, pp. 91–95, 1995. /*ref*/Benabid, A. L. Deep brain stimulation for Parkinson’s disease. 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Cooper, J. M. Henderson and C. C. McIntyre, “Patient-specific analysis of the volume of tissue activated during deep brain stimulation”, NeuroImage, 2007. /*ref*/L.J. Segerind, “Applied Finite Element Analysis”, New York: JohnWiley & Sons, 1984. /*ref*/J. W. Kim and P. A. Robinson, “Compact dynamical model of brain activity”, American Physical Society, Phys. Rev. E. 031907, Vol. 75, i. 3, p. 031907-031917 , 2007. /*ref*/A. Chaturvedi, C. R. Butson, F. Scott, F. Lempka, E. Cooper, and C. Cameron, “Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictions. Brain Stimulation”, vol.3, no. 2, pp. 65–77, 2010. Copyright (c) 2018 ITECKNE application/pdf Universidad Santo Tomás. Seccional Bucaramanga ITECKNE; Vol 11, No 2 (2014); 140-148 2339-3483 1692-1798 ITECKNE; Vol 11, No 2 (2014); 140-148
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