| Sumario: | Objective. Cancer-related fatigue (CRF) is the most common and devastating problem in cancer patients even after successful
treatment. This study aimed to determine the effects of supervised multimodal exercise interventions on cancer-related fatigue
through a systematic review and meta-analysis. Design. A systematic review was conducted to determine the effectiveness of
multimodal exercise interventions on CRF. Databases of PubMed, CENTRAL, EMBASE, and OVID were searched between January
and March 2014 to retrieve randomized controlled trials. Risk of bias was evaluated using the PEDro scale. Results. Nine studies
(𝑛 = 772) were included in both systematic review and meta-analysis. Multimodal interventions including aerobic exercise,
resistance training, and stretching improved CRF symptoms (SMD = −0.23; 95% CI: −0.37 to −0.09; 𝑃 = 0.001). These effects were
also significant in patients undergoing chemotherapy (𝑃 < 0.0001). Nonsignificant differences were found for resistance training
interventions(𝑃 = 0.30). Slight evidence of publication bias was observed (𝑃 = 0.04).The studies had a low risk of bias (PEDro scale
mean score of 6.4 (standard deviation (SD) ± 1.0)). Conclusion. Supervised multimodal exercise interventions including aerobic,
resistance, and stretching exercises are effective in controlling CRF. These findings suggest that these exercise protocols should be
included as a crucial part of the rehabilitation programs for cancer survivors and patients during anticancer treatments.
|
|---|
