The pamoras, their utilitites and advances in the treatment of side effects opiod on mu receptors

The aim of this paper is to review the state of knowledge of the utilities of the Pamoras in treating the collateral ef- fects of opioids with mu receptors. We searched the scientific literature between the years 2001-2010 from which we conclude that Pamoras, particularly methylnaltrexone and alvimo...

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Autores Principales: Daza Barriga, Jorge, Ruiz Pérez, Ornella
Formato: http://purl.org/coar/resource_type/c_6501
Lenguaje:Español (Spanish)
Publicado: Universidad Libre 2011
Acceso en línea:http://hdl.handle.net/10901/14737
id ir-10901-14737
recordtype dspace
spelling ir-10901-147372021-04-13T15:36:05Z The pamoras, their utilitites and advances in the treatment of side effects opiod on mu receptors Las pamoras, sus utilidades y avances en el tratamiento de los efectos colaterales de los opioides en los receptores mu Daza Barriga, Jorge Ruiz Pérez, Ornella The aim of this paper is to review the state of knowledge of the utilities of the Pamoras in treating the collateral ef- fects of opioids with mu receptors. We searched the scientific literature between the years 2001-2010 from which we conclude that Pamoras, particularly methylnaltrexone and alvimopan have proved useful in the treatment of gastrointestinal effects, to the extent that its use has been approved by the Food and Drug Administration. Prob- ably other undesirable effects of opioids such as urinary retention, nausea and itching may also be treated with these substances, but additional research is needed. In addition, intensively studied the effects of actions on other cellular pamoras undesirable opiates, such as tumor growth and increased vascular permeability. The actions are mediated primarily by peripheral mu receptor antagonism. El objetivo del presente trabajo es revisar el estado de conocimientos sobre las utilidades de sustancias antagó- nicas de receptores mu de acción periférica (pamoras), en el tratamiento de los efectos colaterales de opiáceos relacionados con los receptores mu. Se realizó una búsqueda de literatura entre 2001-2010, a partir de la cual se concluye que las pamoras, particularmente la metilnaltrexona y el alvimopan han mostrado utilidad en el trata- miento de efectos gastrointestinales, hasta el punto que su uso ha sido aprobado por la Food and Drug Administra- tion. Probablemente otros efectos indeseables de los opiáceos tales como: retención urinaria, náuseas y prurito puedan ser tratados con estas sustancias, pero se requiere investigación adicional. Además, en la actualidad se estudian intensamente los efectos de las pamoras sobre otras acciones celulares no deseables de los opiáceos, tales como crecimiento tumoral y aumento de la permeabilidad vascular. Las acciones son mediadas por antago- nismo en receptores mu periféricos. 2011-12-01 2019-03-19T16:16:14Z 2019-03-19T16:16:14Z http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85 https://revistas.unilibre.edu.co/index.php/biociencias/article/view/2782 http://hdl.handle.net/10901/14737 spa https://revistas.unilibre.edu.co/index.php/biociencias/article/view/2782/2202 Revistas - Ciencias de la Salud http://creativecommons.org/licenses/by-nc-nd/2.5/co/ Atribución-NoComercial-SinDerivadas 2.5 Colombia application/pdf Universidad Libre Biociencias; Vol 6 No 2 (2011): Biociencias; 73-82 Biociencias; Vol. 6 Núm. 2 (2011): Biociencias; 73-82 2390-0512 0124-0110
institution Universidad Libre de Colombia
collection DSpace
language Español (Spanish)
description The aim of this paper is to review the state of knowledge of the utilities of the Pamoras in treating the collateral ef- fects of opioids with mu receptors. We searched the scientific literature between the years 2001-2010 from which we conclude that Pamoras, particularly methylnaltrexone and alvimopan have proved useful in the treatment of gastrointestinal effects, to the extent that its use has been approved by the Food and Drug Administration. Prob- ably other undesirable effects of opioids such as urinary retention, nausea and itching may also be treated with these substances, but additional research is needed. In addition, intensively studied the effects of actions on other cellular pamoras undesirable opiates, such as tumor growth and increased vascular permeability. The actions are mediated primarily by peripheral mu receptor antagonism.
format http://purl.org/coar/resource_type/c_6501
author Daza Barriga, Jorge
Ruiz Pérez, Ornella
spellingShingle Daza Barriga, Jorge
Ruiz Pérez, Ornella
The pamoras, their utilitites and advances in the treatment of side effects opiod on mu receptors
author_facet Daza Barriga, Jorge
Ruiz Pérez, Ornella
author_sort Daza Barriga, Jorge
title The pamoras, their utilitites and advances in the treatment of side effects opiod on mu receptors
title_short The pamoras, their utilitites and advances in the treatment of side effects opiod on mu receptors
title_full The pamoras, their utilitites and advances in the treatment of side effects opiod on mu receptors
title_fullStr The pamoras, their utilitites and advances in the treatment of side effects opiod on mu receptors
title_full_unstemmed The pamoras, their utilitites and advances in the treatment of side effects opiod on mu receptors
title_sort pamoras, their utilitites and advances in the treatment of side effects opiod on mu receptors
publisher Universidad Libre
publishDate 2011
url http://hdl.handle.net/10901/14737
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