Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings

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Autores Principales: Guerrero, Juan I., Barragán, Luis A., Martínez, Juan D., Montoya, Juan P., Peña, Alejandra, Sobrino, Fidel E., Tovar Spinoza, Zulma, Ghotme Ghotme, Kemel Ahmed
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 11/1
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Acceso en línea:http://hdl.handle.net/10818/44055
id ir-10818-44055
recordtype dspace
spelling ir-10818-440552022-05-10T10:21:51Z Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings Guerrero, Juan I. Barragán, Luis A. Martínez, Juan D. Montoya, Juan P. Peña, Alejandra Sobrino, Fidel E. Tovar Spinoza, Zulma Ghotme Ghotme, Kemel Ahmed Central and peripheral nervous system SARS-CoV-2 COVID-19 Pathophysiology Clinical manifestations Neuropathology Neuroimaging Electrophysiology Cerebrospinal fluid findings páginas Background: SARS-CoV-2 can affect the human brain and other neurological structures. An increasing number of publications report neurological manifestations in patients with COVID-19. However, no studies have comprehensively reviewed the clinical and paraclinical characteristics of the central and peripheral nervous system's involvement in these patients. This study aimed to describe the features of the central and peripheral nervous system involvement by COVID-19 in terms of pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings. Methods: We conducted a comprehensive systematic review of all the original studies reporting patients with neurological involvement by COVID-19, from December 2019 to June 2020, without language restriction. We excluded studies with animal subjects, studies not related to the nervous system, and opinion articles. Data analysis combined descriptive measures, frequency measures, central tendency measures, and dispersion measures for all studies reporting neurological conditions and abnormal ancillary tests in patients with confirmed COVID-19. Results: A total of 143 observational and descriptive studies reported central and peripheral nervous system involvement by COVID-19 in 10723 patients. Fifty-one studies described pathophysiologic mechanisms of neurological involvement by COVID-19, 119 focused on clinical manifestations, 4 described neuropathology findings, 62 described neuroimaging findings, 28 electrophysiology findings, and 60 studies reported cerebrospinal fluid results. The reviewed studies reflect a significant prevalence of the nervous system's involvement in patients with COVID-19, ranging from 22.5% to 36.4% among different studies, without mortality rates explicitly associated with neurological involvement by SARS-COV-2. We thoroughly describe the clinical and paraclinical characteristics of neurological involvement in these patients. Conclusions: Our evidence synthesis led to a categorical analysis of the central and peripheral involvement by COVID-19 and provided a comprehensive explanation of the reported pathophysiological mechanisms by which SARS-CoV-2 infection may cause neurological impairment. International collaborative efforts and exhaustive neurological registries will enhance the translational knowledge of COVID-19's CNS and PNS involvement and generate strategies for therapeutic decision-making. 11/10/2020 18:38 2020-11-10T23:38:57Z 2020-07-24 article publishedVersion http://hdl.handle.net/10818/44055 eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ openAccess application/pdf Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana https://intellectum.unisabana.edu.co
institution Universidad de La Sabana
collection DSpace
language Inglés (English)
topic Central and peripheral nervous system
SARS-CoV-2
COVID-19
Pathophysiology
Clinical manifestations
Neuropathology
Neuroimaging
Electrophysiology
Cerebrospinal fluid findings
spellingShingle Central and peripheral nervous system
SARS-CoV-2
COVID-19
Pathophysiology
Clinical manifestations
Neuropathology
Neuroimaging
Electrophysiology
Cerebrospinal fluid findings
Guerrero, Juan I.
Barragán, Luis A.
Martínez, Juan D.
Montoya, Juan P.
Peña, Alejandra
Sobrino, Fidel E.
Tovar Spinoza, Zulma
Ghotme Ghotme, Kemel Ahmed
Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
description páginas
format Artículo (Article)
author Guerrero, Juan I.
Barragán, Luis A.
Martínez, Juan D.
Montoya, Juan P.
Peña, Alejandra
Sobrino, Fidel E.
Tovar Spinoza, Zulma
Ghotme Ghotme, Kemel Ahmed
author_facet Guerrero, Juan I.
Barragán, Luis A.
Martínez, Juan D.
Montoya, Juan P.
Peña, Alejandra
Sobrino, Fidel E.
Tovar Spinoza, Zulma
Ghotme Ghotme, Kemel Ahmed
author_sort Guerrero, Juan I.
title Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
title_short Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
title_full Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
title_fullStr Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
title_full_unstemmed Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
title_sort central and peripheral nervous system involvement by covid-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
publishDate 11/1
url http://hdl.handle.net/10818/44055
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score 12,131701