Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus
9 páginas
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| Formato: | Artículo (Article) |
| Lenguaje: | Inglés (English) |
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The Journal of Rheumatology
5/6/
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| Acceso en línea: | http://hdl.handle.net/10818/35472 |
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ir-10818-354722022-05-10T10:18:14Z Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus Mora Karam, Claudia Marcela Medina Rosas, Jorge Santos Granados, Ana María Jaimes Fernández, Diego Alejandro Arbeláez, Ana Milena Romero, Consuelo Cortes, Annie Londoño Patiño, John Darío SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX CD ANTIGENS DISEASE ACTIVITY SLEDAI BIOLOGICAL MARKERS 9 páginas Objective There are no laboratory tools that detect early flares in systemic lupus erythematosus (SLE). Our aim was to validate in our population the previous findings of the association of C4d-bearing reticulocytes (R-C4d) compared to anti-dsDNA antibodies, with disease activity assessed by the Safety of Estrogens in Lupus Erythematosus National Assessment–Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) and the British Isles Lupus Assessment Group (BILAG) 2004 scales. Methods All patients who met the 1987 American College of Rheumatology classification criteria and were seen consecutively in 2013 at a specialized SLE care clinic were included. Disease activity was established by the SELENA-SLEDAI and BILAG 2004. Anti-dsDNA and R-C4d were quantified in peripheral blood. Comparisons were made between values of active and inactive patients, and the correlations between the SELENA-SLEDAI and serum levels of anti-dsDNA and R-C4d were measured. Results Sixty-two patients (83.9% women) were included. A total of 32.3% had active disease according to the SELENA-SLEDAI. There was a significant statistical difference (p = 0.0001) in the distribution of R-C4d between disease activity groups. The correlation coefficient between R-C4d and the SELENA-SLEDAI score was rs = 0.738 (p = 0.0001). R-C4d differed between patients with and without activity in the BILAG 2004 constitutional, mucocutaneous, gastrointestinal, renal, and hematological domains. Conclusion R-C4d showed a higher correlation with SLE activity measured by the SELENA-SLEDAI and BILAG 2004 than anti-dsDNA did, suggesting a possible involvement in diagnosing disease activity. Prospective studies that confirm these findings and evaluate its involvement in followup are needed. 5/6/2019 10:07 2019-05-06T15:07:28Z 2016-05 article publishedVersion 0315-162X http://www.jrheum.org/content/early/2016/04/22/jrheum.150486.abstract http://www.jrheum.org/content/jrheum/early/2016/04/22/jrheum.150486.full.pdf http://hdl.handle.net/10818/35472 eng The Journal of Rheumatology 2016; 43:7 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ openAccess application/pdf The Journal of Rheumatology Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana https://intellectum.unisabana.edu.co |
| institution |
Universidad de La Sabana |
| collection |
DSpace |
| language |
Inglés (English) |
| topic |
SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX CD ANTIGENS DISEASE ACTIVITY SLEDAI BIOLOGICAL MARKERS |
| spellingShingle |
SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX CD ANTIGENS DISEASE ACTIVITY SLEDAI BIOLOGICAL MARKERS Mora Karam, Claudia Marcela Medina Rosas, Jorge Santos Granados, Ana María Jaimes Fernández, Diego Alejandro Arbeláez, Ana Milena Romero, Consuelo Cortes, Annie Londoño Patiño, John Darío Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus |
| description |
9 páginas |
| format |
Artículo (Article) |
| author |
Mora Karam, Claudia Marcela Medina Rosas, Jorge Santos Granados, Ana María Jaimes Fernández, Diego Alejandro Arbeláez, Ana Milena Romero, Consuelo Cortes, Annie Londoño Patiño, John Darío |
| author_facet |
Mora Karam, Claudia Marcela Medina Rosas, Jorge Santos Granados, Ana María Jaimes Fernández, Diego Alejandro Arbeláez, Ana Milena Romero, Consuelo Cortes, Annie Londoño Patiño, John Darío |
| author_sort |
Mora Karam, Claudia Marcela |
| title |
Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus |
| title_short |
Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus |
| title_full |
Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus |
| title_fullStr |
Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus |
| title_full_unstemmed |
Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus |
| title_sort |
associations of the levels of c4d-bearing reticulocytes and high-avidity anti-dsdna antibodies with disease activity in systemic lupus erythematosus |
| publisher |
The Journal of Rheumatology |
| publishDate |
5/6/ |
| url |
http://hdl.handle.net/10818/35472 |
| _version_ |
1741873735137230848 |
| score |
12,131701 |