Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
8 páginas
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| Formato: | Artículo (Article) |
| Lenguaje: | Español (Spanish) |
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11/2
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| Acceso en línea: | http://hdl.handle.net/10818/27973 |
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ir-10818-279732022-05-10T10:17:00Z Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats Gómez Bello, Rosa Margarita Ghotme Ghotme, Kemel Ahmed Botero Espinosa, Lucía Bernal Villegas, Jaime Eduardo Pérez, Rosalía Sampaio Barreto, George Emílio Bustos Cruz, Rosa Helena Olfactory ensheathing cells Electron microscopy Regeneration Neural repair Cell therapy 8 páginas Olfactory nerve derived and olfactory bulb derived olfactory ensheathing cells (OECs) have the ability to promote axonal regeneration and remyelination, both of which are essential in a successful cell transplant. Thus, morphological identification of OECs is a key aspect to develop an applicable cell therapy for injuries to the nervous system. However, there is no clear definition regarding which developmental stage or anatomical origin of OECs is more adequate for neural repair. In the present study, an ultrastructural comparison was made between OECs recovered from primary cultures of olfactory nerve and bulb in two developmental stages. The most notorious difference between cells obtained from olfactory nerve and bulb was the presence of indented nuclei in bulb derived OECs, suggesting a greater ability for possible chemotaxis. In neonatal OECs abundant mitochondria, lipid vacuoles, and smooth endoplasmic reticulum were detected, suggesting an active lipid metabolism, probably involved in synthesis of myelin. Our results suggest that neonatal OECs obtained from olfactory bulb have microscopic properties that could make them more suitable for neural repair. 11/2/2016 14:34 2016-11-02T19:34:02Z 2015-08-06 article publishedVersion 1097-4547 https://repository.javeriana.edu.co/bitstream/handle/10554/47779/sart.pdf?sequence=2&isAllowed=y http://hdl.handle.net/10818/27973 10.1016/j.neures.2015.07.012 spa Neuroscience Research Volume 103, February 2016, Pages 10-17 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ openAccess application/pdf Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana https://intellectum.unisabana.edu.co |
| institution |
Universidad de La Sabana |
| collection |
DSpace |
| language |
Español (Spanish) |
| topic |
Olfactory ensheathing cells Electron microscopy Regeneration Neural repair Cell therapy |
| spellingShingle |
Olfactory ensheathing cells Electron microscopy Regeneration Neural repair Cell therapy Gómez Bello, Rosa Margarita Ghotme Ghotme, Kemel Ahmed Botero Espinosa, Lucía Bernal Villegas, Jaime Eduardo Pérez, Rosalía Sampaio Barreto, George Emílio Bustos Cruz, Rosa Helena Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats |
| description |
8 páginas |
| format |
Artículo (Article) |
| author |
Gómez Bello, Rosa Margarita Ghotme Ghotme, Kemel Ahmed Botero Espinosa, Lucía Bernal Villegas, Jaime Eduardo Pérez, Rosalía Sampaio Barreto, George Emílio Bustos Cruz, Rosa Helena |
| author_facet |
Gómez Bello, Rosa Margarita Ghotme Ghotme, Kemel Ahmed Botero Espinosa, Lucía Bernal Villegas, Jaime Eduardo Pérez, Rosalía Sampaio Barreto, George Emílio Bustos Cruz, Rosa Helena |
| author_sort |
Gómez Bello, Rosa Margarita |
| title |
Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats |
| title_short |
Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats |
| title_full |
Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats |
| title_fullStr |
Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats |
| title_full_unstemmed |
Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats |
| title_sort |
ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats |
| publishDate |
11/2 |
| url |
http://hdl.handle.net/10818/27973 |
| _version_ |
1741873567216173056 |
| score |
12,131701 |