Kaurane-Related Diterpenes as Leishmania Pteridine Redutase Inhibitors: an In-Silico Study

Pteridine reductase-1 (PTR1) is one of enzymes discovered as being responsible for the reduced susceptibility to antifolates (eg, metotrexato) of trypanosomic parasites, which has become a chemotherapeutic target. Therefore, thirteen known kaurane-related diterpenes were evaluated in silico against...

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Detalles Bibliográficos
Autores Principales: Orduz Díaz, Luisa, Bernal, Freddy, Coy Barrera, Ericsson
Formato: Artículo (Article)
Lenguaje:Español (Spanish)
Publicado: Universidad Militar Nueva Granada 2013
Acceso en línea:http://hdl.handle.net/10654/37455