Kaurane-Related Diterpenes as Leishmania Pteridine Redutase Inhibitors: an In-Silico Study
Pteridine reductase-1 (PTR1) is one of enzymes discovered as being responsible for the reduced susceptibility to antifolates (eg, metotrexato) of trypanosomic parasites, which has become a chemotherapeutic target. Therefore, thirteen known kaurane-related diterpenes were evaluated in silico against...
| Autores Principales: | , , |
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| Formato: | Artículo (Article) |
| Lenguaje: | Español (Spanish) |
| Publicado: |
Universidad Militar Nueva Granada
2013
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/10654/37455 |