Genotipificación de HLA-B en pacientes colombianos afectados por el síndrome Stevens-Johnson y la Necrólisis Epidérmica Tóxica

Las reacciones alérgicas a medicamentos cutáneas severas (RAM) como el Síndrome Stevens Johnson (SJS) y la Necrólisis Epidérmica Tóxica (NET),caracterizadas por exantema, erosión de la piel y las membranas mucosas, flictenas, desprendimiento de la piel secundario a la muerte de queratinocitos y comp...

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Autor Principal: León Ruiz, Maria Juliana
Otros Autores: Restrepo, Carlos M.
Formato: Tesis de maestría (Master Thesis)
Lenguaje:Español (Spanish)
Publicado: Universidad del Rosario 2014
Materias:
Acceso en línea:http://repository.urosario.edu.co/handle/10336/8910
id ir-10336-8910
recordtype dspace
institution EdocUR - Universidad del Rosario
collection DSpace
language Español (Spanish)
topic Síndrome Stevens Johnson; Necrólisis Epidérmica Tóxica; HLA-B
Antropología física
Stevens Johnson Syndrome; Toxic Epidermal Necrolysis; HLA-B
Síndrome de Stevens-Johnson
Necrólisis Epidérmica Tóxica
Genética
spellingShingle Síndrome Stevens Johnson; Necrólisis Epidérmica Tóxica; HLA-B
Antropología física
Stevens Johnson Syndrome; Toxic Epidermal Necrolysis; HLA-B
Síndrome de Stevens-Johnson
Necrólisis Epidérmica Tóxica
Genética
León Ruiz, Maria Juliana
Genotipificación de HLA-B en pacientes colombianos afectados por el síndrome Stevens-Johnson y la Necrólisis Epidérmica Tóxica
description Las reacciones alérgicas a medicamentos cutáneas severas (RAM) como el Síndrome Stevens Johnson (SJS) y la Necrólisis Epidérmica Tóxica (NET),caracterizadas por exantema, erosión de la piel y las membranas mucosas, flictenas, desprendimiento de la piel secundario a la muerte de queratinocitos y compromiso ocular. Son infrecuentes en la población pero con elevada morbi-mortalidad, se presentan luego de la administración de diferentes fármacos. En Asia se ha asociado el alelo HLA-B*15:02 como marcador genético para SJS. En Colombia no hay datos de la incidencia de estas RAM, ni de la relación con medicamentos específicos o potenciales y tampoco estudios de aproximación genómica de genes de susceptibilidad.
author2 Restrepo, Carlos M.
author_facet Restrepo, Carlos M.
León Ruiz, Maria Juliana
format Tesis de maestría (Master Thesis)
author León Ruiz, Maria Juliana
author_sort León Ruiz, Maria Juliana
title Genotipificación de HLA-B en pacientes colombianos afectados por el síndrome Stevens-Johnson y la Necrólisis Epidérmica Tóxica
title_short Genotipificación de HLA-B en pacientes colombianos afectados por el síndrome Stevens-Johnson y la Necrólisis Epidérmica Tóxica
title_full Genotipificación de HLA-B en pacientes colombianos afectados por el síndrome Stevens-Johnson y la Necrólisis Epidérmica Tóxica
title_fullStr Genotipificación de HLA-B en pacientes colombianos afectados por el síndrome Stevens-Johnson y la Necrólisis Epidérmica Tóxica
title_full_unstemmed Genotipificación de HLA-B en pacientes colombianos afectados por el síndrome Stevens-Johnson y la Necrólisis Epidérmica Tóxica
title_sort genotipificación de hla-b en pacientes colombianos afectados por el síndrome stevens-johnson y la necrólisis epidérmica tóxica
publisher Universidad del Rosario
publishDate 2014
url http://repository.urosario.edu.co/handle/10336/8910
_version_ 1645141606752321536
spelling ir-10336-89102019-09-19T12:37:54Z Genotipificación de HLA-B en pacientes colombianos afectados por el síndrome Stevens-Johnson y la Necrólisis Epidérmica Tóxica León Ruiz, Maria Juliana Restrepo, Carlos M. Síndrome Stevens Johnson; Necrólisis Epidérmica Tóxica; HLA-B Antropología física Stevens Johnson Syndrome; Toxic Epidermal Necrolysis; HLA-B Síndrome de Stevens-Johnson Necrólisis Epidérmica Tóxica Genética Las reacciones alérgicas a medicamentos cutáneas severas (RAM) como el Síndrome Stevens Johnson (SJS) y la Necrólisis Epidérmica Tóxica (NET),caracterizadas por exantema, erosión de la piel y las membranas mucosas, flictenas, desprendimiento de la piel secundario a la muerte de queratinocitos y compromiso ocular. Son infrecuentes en la población pero con elevada morbi-mortalidad, se presentan luego de la administración de diferentes fármacos. En Asia se ha asociado el alelo HLA-B*15:02 como marcador genético para SJS. En Colombia no hay datos de la incidencia de estas RAM, ni de la relación con medicamentos específicos o potenciales y tampoco estudios de aproximación genómica de genes de susceptibilidad. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions (SCARs) characterized by exanthema, erosion of the skin and mucous membranes, blistering, skin detachment secondary to keratinocyte death, and ocular involvement. There are uncommon in the population but with high morbidity and mortality. In Asia has been associated HLA-B*15:02 allele as a genetic marker for SJS. 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