16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus

Background: The 16/6-idiotype (16/6-Id) of the human anti-DNA antibody was found to induce experimental lupus in naive mice, manifested by production of autoantibodies, leukopenia and elevated inflammatory markers, as well as kidney and brain involvement. We assessed behavior and brain pathology of...

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Detalles Bibliográficos
Autores Principales: Shaye, Kivity, Katzav, Aviva, Arango, María-Teresa, Landau-Rabi, Moran, Zafrir, Yaron, Agmon-Levin, Nancy, Blank, Miri, Anaya, Juan-Manuel, Mozes, Edna, Chapman, Joab, Shoenfeld, Yehuda
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Universidad del Rosario 2013
Materias:
Acceso en línea:http://repository.urosario.edu.co/handle/10336/8833