Preferential binding to elk-1 by sle-associated il10 risk allele upregulates il10 expression
Immunoregulatory cytokine interleukin-10 (IL-10) is elevated in sera from patients with systemic lupus erythematosus (SLE) correlating with disease activity. The established association of IL10 with SLE and other autoimmune diseases led us to fine map causal variant(s) and to explore underlying mech...
Autores Principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Artículo (Article) |
Lenguaje: | Inglés (English) |
Publicado: |
Universidad del Rosario
2013
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Materias: | |
Acceso en línea: | http://repository.urosario.edu.co/handle/10336/8828 https://doi.org/10.1371/journal.pgen.1003870 |