Lupus nephritis: an overview of recent findings

Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. In susceptible individuals suffering of SLE, in situ formation and deposit of immune complexes (ICs) from apoptotic bodies occur in the kidneys as a...

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Autores Principales: Herrera-Díaz, Ana-Catalina, Zubiria Salgado, Alberto de
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Universidad del Rosario 2012
Materias:
Acceso en línea:http://repository.urosario.edu.co/handle/10336/8821
id ir-10336-8821
recordtype dspace
spelling ir-10336-88212019-09-19T12:38:03Z Lupus nephritis: an overview of recent findings Herrera-Díaz, Ana-Catalina Zubiria Salgado, Alberto de Enfermedades Nefritis lúpica Enfermedades de los riñones Células dendríticas Fibrosis Lupus eritematoso sistémico Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. In susceptible individuals suffering of SLE, in situ formation and deposit of immune complexes (ICs) from apoptotic bodies occur in the kidneys as a result of an amplified epitope immunological response. IC glomerular deposits generate release of proinflammatory cytokines and cell adhesion molecules causing inflammation. This leads to monocytes and polymorphonuclear cells chemotaxis. Subsequent release of proteases generates endothelial injury and mesangial proliferation. Presence of ICs promotes adaptive immune response and causes dendritic cells to release type I interferon. This induces maturation and activation of infiltrating T cells, and amplification of Th2, Th1 and Th17 lymphocytes. Each of them, amplify B cells and activates macrophages to release more proinflammatory molecules, generating effector cells that cannot be modulated promoting kidney epithelial proliferation and fibrosis. Herein immunopathological findings of LN are reviewed. 2012 2014-08-12T20:05:40Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion ISSN:2090-0430 http://repository.urosario.edu.co/handle/10336/8821 eng info:eu-repo/semantics/openAccess application/pdf Universidad del Rosario instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Enfermedades
Nefritis lúpica
Enfermedades de los riñones
Células dendríticas
Fibrosis
Lupus eritematoso sistémico
spellingShingle Enfermedades
Nefritis lúpica
Enfermedades de los riñones
Células dendríticas
Fibrosis
Lupus eritematoso sistémico
Herrera-Díaz, Ana-Catalina
Zubiria Salgado, Alberto de
Lupus nephritis: an overview of recent findings
description Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. In susceptible individuals suffering of SLE, in situ formation and deposit of immune complexes (ICs) from apoptotic bodies occur in the kidneys as a result of an amplified epitope immunological response. IC glomerular deposits generate release of proinflammatory cytokines and cell adhesion molecules causing inflammation. This leads to monocytes and polymorphonuclear cells chemotaxis. Subsequent release of proteases generates endothelial injury and mesangial proliferation. Presence of ICs promotes adaptive immune response and causes dendritic cells to release type I interferon. This induces maturation and activation of infiltrating T cells, and amplification of Th2, Th1 and Th17 lymphocytes. Each of them, amplify B cells and activates macrophages to release more proinflammatory molecules, generating effector cells that cannot be modulated promoting kidney epithelial proliferation and fibrosis. Herein immunopathological findings of LN are reviewed.
format Artículo (Article)
author Herrera-Díaz, Ana-Catalina
Zubiria Salgado, Alberto de
author_facet Herrera-Díaz, Ana-Catalina
Zubiria Salgado, Alberto de
author_sort Herrera-Díaz, Ana-Catalina
title Lupus nephritis: an overview of recent findings
title_short Lupus nephritis: an overview of recent findings
title_full Lupus nephritis: an overview of recent findings
title_fullStr Lupus nephritis: an overview of recent findings
title_full_unstemmed Lupus nephritis: an overview of recent findings
title_sort lupus nephritis: an overview of recent findings
publisher Universidad del Rosario
publishDate 2012
url http://repository.urosario.edu.co/handle/10336/8821
_version_ 1651341381504860160
score 12,131701