Identification and Diversity of Killer Cell Ig-Like Receptors in Aotus vociferans, a New World Monkey

Previous BAC clone analysis of the Platyrrhini owl monkey KIRs have shown an unusual genetic structure in some loci. Therefore, cDNAs encoding KIR molecules from eleven Aotus vociferans monkeys were characterized here; tenputative KIR loci were found, some of which encoded atypical proteins such as...

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Autores Principales: Garzón Ospina, Diego, López, Carolina, Cadavid, Luis, Patarroyo, Manuel E., Patarroyo, Manuel A.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Universidad del Rosario 2013
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Acceso en línea:http://repository.urosario.edu.co/handle/10336/8816
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spelling ir-10336-88162019-09-19T12:38:03Z Identification and Diversity of Killer Cell Ig-Like Receptors in Aotus vociferans, a New World Monkey Garzón Ospina, Diego López, Carolina Cadavid, Luis Patarroyo, Manuel E. Patarroyo, Manuel A. Evolución & genética Aanálisis filogenético Genética Genes Previous BAC clone analysis of the Platyrrhini owl monkey KIRs have shown an unusual genetic structure in some loci. Therefore, cDNAs encoding KIR molecules from eleven Aotus vociferans monkeys were characterized here; tenputative KIR loci were found, some of which encoded atypical proteins such as KIR4DL and transcripts predicted to encode a D0+D1 configuration (AOTVOKIR2DL1*01v1) which appear to be unique in the Aotus genus. Furthermore, alternative splicing was found as a likely mechanism for producing activator receptors in A. vociferans species. KIR proteins from New World monkeys may be split into three new lineages according to domain by domain phylogenetic analysis. Although the A. vociferans KIR family displayed a high divergence among paralogous genes, individual loci were limited in their genetic polymorphism. Selection analysis showed that both constrained and rapid evolution may operate within the AvKIR family. The frequent alternative splicing (as a likely mechanism generating activator receptors), the presence of KIR4DL and KIR2DL1 (D0+D1) molecules and other data reported here suggest that the KIR family in Aotus has had a rapid evolution, independent from its Catarrhini counterparts.from its Catarrhini counterparts. 2013-11 2014-08-12T19:10:37Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion ISSN:1932-6203 http://repository.urosario.edu.co/handle/10336/8816 eng info:eu-repo/semantics/openAccess application/pdf Universidad del Rosario instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Evolución & genética
Aanálisis filogenético
Genética
Genes
spellingShingle Evolución & genética
Aanálisis filogenético
Genética
Genes
Garzón Ospina, Diego
López, Carolina
Cadavid, Luis
Patarroyo, Manuel E.
Patarroyo, Manuel A.
Identification and Diversity of Killer Cell Ig-Like Receptors in Aotus vociferans, a New World Monkey
description Previous BAC clone analysis of the Platyrrhini owl monkey KIRs have shown an unusual genetic structure in some loci. Therefore, cDNAs encoding KIR molecules from eleven Aotus vociferans monkeys were characterized here; tenputative KIR loci were found, some of which encoded atypical proteins such as KIR4DL and transcripts predicted to encode a D0+D1 configuration (AOTVOKIR2DL1*01v1) which appear to be unique in the Aotus genus. Furthermore, alternative splicing was found as a likely mechanism for producing activator receptors in A. vociferans species. KIR proteins from New World monkeys may be split into three new lineages according to domain by domain phylogenetic analysis. Although the A. vociferans KIR family displayed a high divergence among paralogous genes, individual loci were limited in their genetic polymorphism. Selection analysis showed that both constrained and rapid evolution may operate within the AvKIR family. The frequent alternative splicing (as a likely mechanism generating activator receptors), the presence of KIR4DL and KIR2DL1 (D0+D1) molecules and other data reported here suggest that the KIR family in Aotus has had a rapid evolution, independent from its Catarrhini counterparts.from its Catarrhini counterparts.
format Artículo (Article)
author Garzón Ospina, Diego
López, Carolina
Cadavid, Luis
Patarroyo, Manuel E.
Patarroyo, Manuel A.
author_facet Garzón Ospina, Diego
López, Carolina
Cadavid, Luis
Patarroyo, Manuel E.
Patarroyo, Manuel A.
author_sort Garzón Ospina, Diego
title Identification and Diversity of Killer Cell Ig-Like Receptors in Aotus vociferans, a New World Monkey
title_short Identification and Diversity of Killer Cell Ig-Like Receptors in Aotus vociferans, a New World Monkey
title_full Identification and Diversity of Killer Cell Ig-Like Receptors in Aotus vociferans, a New World Monkey
title_fullStr Identification and Diversity of Killer Cell Ig-Like Receptors in Aotus vociferans, a New World Monkey
title_full_unstemmed Identification and Diversity of Killer Cell Ig-Like Receptors in Aotus vociferans, a New World Monkey
title_sort identification and diversity of killer cell ig-like receptors in aotus vociferans, a new world monkey
publisher Universidad del Rosario
publishDate 2013
url http://repository.urosario.edu.co/handle/10336/8816
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score 11,383098