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MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

We previously reported that the G allele of rs3853839 at 3′untranslated region (UTR) of Toll-like receptor 7 (TLR7) was associated with elevated transcript expression and increased risk for systemic lupus erythematosus (SLE) in 9,274 Eastern Asians [P = 6.5×10−10, odds ratio (OR) (95%CI) = 1.27 (1.1...

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Detalles Bibliográficos
Autores Principales: Deng, Yun, Zhao, Jian, Sakurai, Daisuke, Kaufman, Kenneth M., Edberg, Jeffrey C., Kimberly, Robert P., Kamen, Diane L., Gilkeson, Gary S., Jacob, Chaim O., Scofield, Robert H., Langefeld, Carl D., Kelly, Jennifer A., Ramsey-Goldman, Rosalind, Petri, Michelle A., Reveille, John D., Vilá, Luis M., Alarcón, Graciela S., Vyse, Timothy J., Pons-Estel, Bernardo A., Freedman, Barry I., Gaffney, Patrick M., Moser Sivils, Kathy, James, Judith A., Gregersen, Peter K., Anaya, Juan-Manuel, Niewold, Timothy B., Merrill, Joan T., Criswell, Lindsey A., Stevens, Anne M., Boackle, Susan, Cantor, Rita M., Chen, Weiling, Grossman, Jenniffer M., Hahn, Bevra H., Harley, John B., Alarcón-Riquelme, Marta E., Brown, Elizabeth E., Tsao, Betty P.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Universidad del Rosario 2013
Materias:
Enfermedades
GENOME-WIDE ASSOCIATION
IMMUNE-RESPONSES
TLR7
SUSCEPTIBILITY
POLYMORPHISMS
AUTOIMMUNITY
POPULATION
ITGAM
WOMEN
LOCI
Genoma humano
Enfermedades autoinmunes
Inmunología
Lupus eritematoso sistémico
Acceso en línea:http://repository.urosario.edu.co/handle/10336/8810

Internet

http://repository.urosario.edu.co/handle/10336/8810

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