Soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura

El traumatismo craneoencefálico, es la epidemia silenciosa de nuestra época, que genera gastos en salud, en países como Estados Unidos, cercanos a los 60 billones de dólares anuales, y cerca de 400 billones en rehabilitación de los discapacitados. El pilar del manejo médico del trauma craneoencefáli...

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Detalles Bibliográficos
Autores Principales: Vitola Domínguez, Alexander, Perdomo, Andrés Mauricio
Otros Autores: Villabona Luna, Rafael
Formato: Trabajo de grado (Bachelor Thesis)
Lenguaje:Español (Spanish)
Publicado: Universidad del Rosario 2014
Materias:
Acceso en línea:http://repository.urosario.edu.co/handle/10336/8787
id ir-10336-8787
recordtype dspace
institution EdocUR - Universidad del Rosario
collection DSpace
language Español (Spanish)
topic Trauma Craneoencefálico, Edema Cerebral Traumático, Edema Cerebral, Osmoterapia, Terapia Osmótica, Salina Hipertónica, Soluciones Hipertónicas, Soluciones Salinas Hipertónicas, Manitol.
Ciencias médicas, Medicina
Traumatic Brain Injury, Traumatic Brain Edema, Brain Edema, Osmotherapy, Osmotic Therapy, Hypertonic Saline, Hypertonic Solutions, Hypertonic Saline Solutions, Mannitol.
Trauma Craneoencefálico
Edema Cerebral
Terapia osmótica
Soluciones hipertónicas
spellingShingle Trauma Craneoencefálico, Edema Cerebral Traumático, Edema Cerebral, Osmoterapia, Terapia Osmótica, Salina Hipertónica, Soluciones Hipertónicas, Soluciones Salinas Hipertónicas, Manitol.
Ciencias médicas, Medicina
Traumatic Brain Injury, Traumatic Brain Edema, Brain Edema, Osmotherapy, Osmotic Therapy, Hypertonic Saline, Hypertonic Solutions, Hypertonic Saline Solutions, Mannitol.
Trauma Craneoencefálico
Edema Cerebral
Terapia osmótica
Soluciones hipertónicas
Vitola Domínguez, Alexander
Perdomo, Andrés Mauricio
Soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura
description El traumatismo craneoencefálico, es la epidemia silenciosa de nuestra época, que genera gastos en salud, en países como Estados Unidos, cercanos a los 60 billones de dólares anuales, y cerca de 400 billones en rehabilitación de los discapacitados. El pilar del manejo médico del trauma craneoencefálico moderado o severo, es la osmoterapia, principalmente con sustancias como el manitol y las soluciones hipertónicas. Se realizó la revisión de 14 bases de datos, encontrando 4657754 artículos, quedando al final 40 artículos después de un análisis exhaustivo, que se relacionaban con el manejo de la hipertensión endocraneana y terapia osmótica. Resultados: Se compararon diferentes estudios, encontrando gran variabilidad estos, sin homogenización en los análisis estadísticos, y la poca rigurosidad no permitieron, la recolección de datos y la comparación entre los diferentes estudios, no permitió realizar el meta-análisis y por esto se decidió la realización de una revisión sistemática de la literatura. Se evidenció principalmente tres cosas: la primera es la poca rigurosidad con la que se realizan los estudios clínicos; la segunda, es que aún falta mucha más investigación principalmente, la presencia de estudios clínicos aleatorizados multicéntricos, que logren dar una sólida evidencia y que genere validez científica que se requiere, a pesar de la evidencia clara en la práctica clínica; la tercera es la seguridad para su uso, con poca presencia de complicaciones para las soluciones salinas hipertónicas.
author2 Villabona Luna, Rafael
author_facet Villabona Luna, Rafael
Vitola Domínguez, Alexander
Perdomo, Andrés Mauricio
format Trabajo de grado (Bachelor Thesis)
author Vitola Domínguez, Alexander
Perdomo, Andrés Mauricio
author_sort Vitola Domínguez, Alexander
title Soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura
title_short Soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura
title_full Soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura
title_fullStr Soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura
title_full_unstemmed Soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura
title_sort soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura
publisher Universidad del Rosario
publishDate 2014
url http://repository.urosario.edu.co/handle/10336/8787
_version_ 1645141183997935616
spelling ir-10336-87872019-09-19T12:37:54Z Soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura Vitola Domínguez, Alexander Perdomo, Andrés Mauricio Villabona Luna, Rafael Trauma Craneoencefálico, Edema Cerebral Traumático, Edema Cerebral, Osmoterapia, Terapia Osmótica, Salina Hipertónica, Soluciones Hipertónicas, Soluciones Salinas Hipertónicas, Manitol. Ciencias médicas, Medicina Traumatic Brain Injury, Traumatic Brain Edema, Brain Edema, Osmotherapy, Osmotic Therapy, Hypertonic Saline, Hypertonic Solutions, Hypertonic Saline Solutions, Mannitol. Trauma Craneoencefálico Edema Cerebral Terapia osmótica Soluciones hipertónicas El traumatismo craneoencefálico, es la epidemia silenciosa de nuestra época, que genera gastos en salud, en países como Estados Unidos, cercanos a los 60 billones de dólares anuales, y cerca de 400 billones en rehabilitación de los discapacitados. El pilar del manejo médico del trauma craneoencefálico moderado o severo, es la osmoterapia, principalmente con sustancias como el manitol y las soluciones hipertónicas. Se realizó la revisión de 14 bases de datos, encontrando 4657754 artículos, quedando al final 40 artículos después de un análisis exhaustivo, que se relacionaban con el manejo de la hipertensión endocraneana y terapia osmótica. Resultados: Se compararon diferentes estudios, encontrando gran variabilidad estos, sin homogenización en los análisis estadísticos, y la poca rigurosidad no permitieron, la recolección de datos y la comparación entre los diferentes estudios, no permitió realizar el meta-análisis y por esto se decidió la realización de una revisión sistemática de la literatura. Se evidenció principalmente tres cosas: la primera es la poca rigurosidad con la que se realizan los estudios clínicos; la segunda, es que aún falta mucha más investigación principalmente, la presencia de estudios clínicos aleatorizados multicéntricos, que logren dar una sólida evidencia y que genere validez científica que se requiere, a pesar de la evidencia clara en la práctica clínica; la tercera es la seguridad para su uso, con poca presencia de complicaciones para las soluciones salinas hipertónicas. Traumatic Brain Injury is the silent epidemic disease actually, and generates spent of health costs about 60 billion dollars per year, and almost 400 billion dollars in rehabilitation in survivors. The cornerstone, in the treatment of moderate and severe traumatic brain injury, is the Osmotherapy, mainly with substances like Mannitol and Hypertonic Solutions. It was made the research of 14 databases, finding 4657754 articles, leaving 40 trials after an exhaustive analysis, that they were related with intracranial hypertension and osmotic therapy. Comparing the different articles, it was found a great variability in the type of trials without homogenization about statistical analysis, and the lack of stringency, that not allowed the meta-analysis, so the realization of a systematic review of the literature was decided. It was evidenced three things mainly: first, is the lack of stringency how the clinical trials were made; second, it was the deficiency of multicentric random clinical trials, that could give the solid evidence and scientific validity is required, despite the clear evidence in clinical practice; the third is the security for their use with low presence of complications for hypertonic saline solutions. 2014-06-06 2014-08-12T13:49:19Z info:eu-repo/semantics/bachelorThesis info:eu-repo/semantics/acceptedVersion http://repository.urosario.edu.co/handle/10336/8787 spa http://creativecommons.org/licenses/by-nc-nd/2.5/co/ info:eu-repo/semantics/openAccess application/pdf Universidad del Rosario Especialización en Neurología Facultad de Medicina instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR Yue JK, Vassar MJ, Lingsma HF,Cooper SR, OkonkwoDO, Valadka AB, Gordon WA et al. 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