Multiple sclerosis: evidence and controversies

Introduction: Multiple sclerosis is a chronic recurrent inflammatory disorder of the central nervous system. The pharmacological treatment of multiple sclerosis has been evaluated with multiple controlled clinical trials that allow the clinician to count with evidence based information to decide the...

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Autor Principal: Gutiérrez-Álvarez, Ángela-María
Formato: Artículo (Article)
Lenguaje:Español (Spanish)
Publicado: Universidad del Rosario 2010
Materias:
Acceso en línea:http://revistas.urosario.edu.co/index.php/revsalud/article/view/535
http://repository.urosario.edu.co/handle/10336/7566
id ir-10336-7566
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spelling ir-10336-75662019-09-19T12:37:01Z Multiple sclerosis: evidence and controversies Esclerosis múltiple: evidencias y controversias Gutiérrez-Álvarez, Ángela-María Multiple sclerosis; diagnosis; interferons esclerosis múltiple; diagnóstico; interferones Introduction: Multiple sclerosis is a chronic recurrent inflammatory disorder of the central nervous system. The pharmacological treatment of multiple sclerosis has been evaluated with multiple controlled clinical trials that allow the clinician to count with evidence based information to decide the more indicated treatment for each patient. Methodology: A review of the scientific literature was conducted to clarify controversial issues in a clinical relevant topic. Development: The diagnostic criteria and different treatments available are reviewed, in order to consider the clinical utility of the disease modifying agents such as the immunomodulatory treatments. The three used types of interferon are well tolerated and reduce in approximately a third the number of bouts in the remitent recurrent form; there is no significant difference between the three of them. Introducción: la esclerosis múltiple es una enfermedad inflamatoria crónica recurrente del Sistema Nervioso Central (SNC) El tratamiento de dicha enfermedad ha sido evaluado con múltiples ensayos clínicos controlados que permiten al clínico, hoy en día, contar con información basada en la evidencia para decidir el tratamiento más indicado para cada paciente. Metodología: este trabajo de revisión bibliográfica parte de la información que sobre este tema se ha publicado en los últimos años, con el objetivo de integrar y actualizar la literatura que trata acerca de esta entidad. Desarrollo: se revisan los criterios diagnósticos y lo relacionado con los tratamientos disponibles que generalmente se han limitado al manejo de las complicaciones de la enfermedad y al uso de corticoides para el tratamiento de los brotes. Los tres tipos de interferón utilizados, son bien tolerados y reducen aproximadamente en un tercio el número de brotes en las formas remitente recurrente de la enfermedad, sin que exista evidencia de diferencias significativas entre ellos. 2010-05-18 2010-05-18 2014-07-09T15:56:09Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://revistas.urosario.edu.co/index.php/revsalud/article/view/535 http://repository.urosario.edu.co/handle/10336/7566 spa http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess application/pdf Universidad del Rosario Revista Ciencias de la Salud; Vol. 4, núm. 1 (2006) Revista Ciencias de la Salud; Vol. 4, núm. 1 (2006) Revista Ciencias de la Salud; Vol. 4, núm. 1 (2006) 2145-4507 1692-7273 reponame:Repositorio Institucional EdocUR instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Español (Spanish)
topic Multiple sclerosis; diagnosis; interferons
esclerosis múltiple; diagnóstico; interferones
spellingShingle Multiple sclerosis; diagnosis; interferons
esclerosis múltiple; diagnóstico; interferones
Gutiérrez-Álvarez, Ángela-María
Multiple sclerosis: evidence and controversies
description Introduction: Multiple sclerosis is a chronic recurrent inflammatory disorder of the central nervous system. The pharmacological treatment of multiple sclerosis has been evaluated with multiple controlled clinical trials that allow the clinician to count with evidence based information to decide the more indicated treatment for each patient. Methodology: A review of the scientific literature was conducted to clarify controversial issues in a clinical relevant topic. Development: The diagnostic criteria and different treatments available are reviewed, in order to consider the clinical utility of the disease modifying agents such as the immunomodulatory treatments. The three used types of interferon are well tolerated and reduce in approximately a third the number of bouts in the remitent recurrent form; there is no significant difference between the three of them.
format Artículo (Article)
author Gutiérrez-Álvarez, Ángela-María
author_facet Gutiérrez-Álvarez, Ángela-María
author_sort Gutiérrez-Álvarez, Ángela-María
title Multiple sclerosis: evidence and controversies
title_short Multiple sclerosis: evidence and controversies
title_full Multiple sclerosis: evidence and controversies
title_fullStr Multiple sclerosis: evidence and controversies
title_full_unstemmed Multiple sclerosis: evidence and controversies
title_sort multiple sclerosis: evidence and controversies
publisher Universidad del Rosario
publishDate 2010
url http://revistas.urosario.edu.co/index.php/revsalud/article/view/535
http://repository.urosario.edu.co/handle/10336/7566
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score 11,382149