A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS

We present a new framework for the assessment of cerebral hemodynamics regulation (CHR) in neonates using near-infrared spectroscopy (NIRS). In premature infants, NIRS measurements have been used as surrogate variables for cerebral blood flow (CBF) in the assessment of cerebral autoregulation (CA)....

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Autores Principales: Caicedo Dorado, Alexander, Alderliesten, Thomas, Naulaers, Gunnar, Lemmers, Petra, Van Bel, Frank, Van Huffel, Sabine
Formato: Capítulo de libro (Book Chapter)
Lenguaje:Inglés (English)
Publicado: Springer Nature 2016
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/28876
https://doi.org/10.1007/978-1-4939-3023-4_63
id ir-10336-28876
recordtype dspace
spelling ir-10336-288762020-08-28T15:50:42Z A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS Un nuevo marco para la evaluación de la regulación de la hemodinámica cerebral en recién nacidos mediante NIRS Caicedo Dorado, Alexander Alderliesten, Thomas Naulaers, Gunnar Lemmers, Petra Van Bel, Frank Van Huffel, Sabine Cerebral autoregulation NIRS Multivariable Premature infants We present a new framework for the assessment of cerebral hemodynamics regulation (CHR) in neonates using near-infrared spectroscopy (NIRS). In premature infants, NIRS measurements have been used as surrogate variables for cerebral blood flow (CBF) in the assessment of cerebral autoregulation (CA). However, NIRS measurements only reflect changes in CBF under constant changes in arterial oxygen saturation (SaO2). This condition is unlikely to be met at the bedside in the NICU. Additionally, CA is just one of the different highly coupled mechanisms that regulate brain hemodynamics. Traditional methods for the assessment of CA do not take into account the multivariate nature of CHR, producing inconclusive results. In this study we propose a newly developed multivariate methodology for the assessment of CHR. This method is able to effectively decouple the influences of SaO2 from the NIRS measurements, and at the same time, produces scores indicating the strength of the coupling between the systemic variables and NIRS recordings. We explore the use of this method, and its derived scores, for the monitoring of CHR using data from premature infants who developed a grade III-IV intra-ventricular hemorrhage during the first 3 days of life. 2016 2020-08-28T15:49:59Z info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion ISBN: 978-1-4939-3022-7 https://repository.urosario.edu.co/handle/10336/28876 https://doi.org/10.1007/978-1-4939-3023-4_63 eng info:eu-repo/semantics/restrictedAccess application/pdf Springer Nature Advances in Experimental Medicine and Biology
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Cerebral autoregulation
NIRS
Multivariable
Premature infants
spellingShingle Cerebral autoregulation
NIRS
Multivariable
Premature infants
Caicedo Dorado, Alexander
Alderliesten, Thomas
Naulaers, Gunnar
Lemmers, Petra
Van Bel, Frank
Van Huffel, Sabine
A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS
description We present a new framework for the assessment of cerebral hemodynamics regulation (CHR) in neonates using near-infrared spectroscopy (NIRS). In premature infants, NIRS measurements have been used as surrogate variables for cerebral blood flow (CBF) in the assessment of cerebral autoregulation (CA). However, NIRS measurements only reflect changes in CBF under constant changes in arterial oxygen saturation (SaO2). This condition is unlikely to be met at the bedside in the NICU. Additionally, CA is just one of the different highly coupled mechanisms that regulate brain hemodynamics. Traditional methods for the assessment of CA do not take into account the multivariate nature of CHR, producing inconclusive results. In this study we propose a newly developed multivariate methodology for the assessment of CHR. This method is able to effectively decouple the influences of SaO2 from the NIRS measurements, and at the same time, produces scores indicating the strength of the coupling between the systemic variables and NIRS recordings. We explore the use of this method, and its derived scores, for the monitoring of CHR using data from premature infants who developed a grade III-IV intra-ventricular hemorrhage during the first 3 days of life.
format Capítulo de libro (Book Chapter)
author Caicedo Dorado, Alexander
Alderliesten, Thomas
Naulaers, Gunnar
Lemmers, Petra
Van Bel, Frank
Van Huffel, Sabine
author_facet Caicedo Dorado, Alexander
Alderliesten, Thomas
Naulaers, Gunnar
Lemmers, Petra
Van Bel, Frank
Van Huffel, Sabine
author_sort Caicedo Dorado, Alexander
title A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS
title_short A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS
title_full A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS
title_fullStr A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS
title_full_unstemmed A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS
title_sort new framework for the assessment of cerebral hemodynamics regulation in neonates using nirs
publisher Springer Nature
publishDate 2016
url https://repository.urosario.edu.co/handle/10336/28876
https://doi.org/10.1007/978-1-4939-3023-4_63
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score 11,381624