Imagen de Portada

Código QR

Peptide Vaccines for Malaria

Obtaining a highly effective malaria vaccine is a worldwide priority. The first approach aimed at obtaining a malarial vaccine using synthetic peptides was a polymeric chimeric molecule named SPf66, which conferred limited protective efficacy in Aotus monkeys and in large human field-trials. Our eff...

Descripción completa

Detalles Bibliográficos
Autores Principales:	Bermudez Quintero, Adriana Janneth, Lozano Moreno, Jose Manuel, Patarroyo, Manuel Elkin
Formato:	Capítulo de libro (Book Chapter)
Lenguaje:	Inglés (English)
Publicado:	Elsevier 2006
Materias:	Peptide Vaccines for Malaria Main Malarial Antigens MHC II-peptide-TCR
Acceso en línea:	https://repository.urosario.edu.co/handle/10336/28828 https://doi.org/10.1016/B978-012369442-3/50077-5

Ejemplares similares

High non-protective, long-lasting antibody levels in malaria are associated with haplotype shifting in MHC-peptide-TCR complex formation: a new mechanism for immune evasion
por: Patarroyo, Manuel E., et al.
Publicado: (2006)

Based on HLA-DR?1* allele binding specificities, striking differences in distance and tcr contacting residue orientation can be observed in modified protection-inducing malarial synthetic peptides
por: Patarroyo, M. E., et al.
Publicado: (2005)

Atomic fidelity of subunit-based chemically-synthesized antimalarial vaccine components
por: Patarroyo, Manuel E., et al.
Publicado: (2010)

Structural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humans
por: Suárez C.F., et al.
Publicado: (2017)

Structural and immunological analysis of circumsporozoite protein peptides: a further step in the identification of potential components of a minimal subunit-based, chemically synthesised antimalarial vaccine
por: Bermúdez, Adriana, et al.
Publicado: (2008)

Critical role of HLA-DR?* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development
por: Reyes C., et al.
Publicado: (2017)

The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development
por: Reyes C., et al.
Publicado: (2017)

A large size chimeric highly immunogenic peptide presents multistage plasmodium antigens as a vaccine candidate system against malaria
por: Lozano, José Manuel, et al.
Publicado: (2017)

Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria
por: Cubillos, Marcia, et al.
Publicado: (2003)

Conserved binding regions provide the clue for peptide-based vaccine development: A chemical perspective
por: Curtidor, Hernando, et al.
Publicado: (2017)

3D structure and immunogenicity of Plasmodium falciparum sporozoite induced associated protein peptides as components of fully-protective anti-malarial vaccine
por: Alba M.P., et al.
Publicado: (2011)

Electrostatic potential as a tool to understand interactions between malaria vaccine candidate peptides and MHC II molecules
por: Agudelo W.A., et al.
Publicado: (2011)

Malaria: Paving the way to developing peptide-based vaccines against invasion in infectious diseases.
por: Reyes, Cesar, et al.
Publicado: (2020)

Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
por: Lozano, Jose Manuel, et al.
Publicado: (2010)

Recent advances in the development of a chemically synthesised anti-malarial vaccine
por: "Curtidor, Hernando, et al.
Publicado: (2015)

Shortening and modifying the 1513 MSP-1 peptide’s ?-helical region induces protection against malaria
por: Espejo, Fabiola, et al.
Publicado: (2004)

"Redefining an epitope of a malaria vaccine candidate, with antibodies against the N-terminal MSA-2 antigen of Plasmodium harboring non-natural peptide bonds"
por: Lozano, José Manuel, et al.
Publicado: (2013)

Immune protection-inducing protein structures (IMPIPS) against malaria : The weapons needed for beating Odysseus
por: Patarroyo, Manuel E., et al.
Publicado: (2015)

Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins
por: Cifuentes, Gladys, et al.
Publicado: (2009)

Protecting capacity against malaria of chemically defined tetramer forms based on the Plasmodium falciparum apical sushi protein as potential vaccine components
por: Vanegas, Magnolia, et al.
Publicado: (2014)

Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
por: Alaba, Martha Patricia, et al.
Publicado: (2004)

Changing ABRA protein peptide to fit into the HLA-DRbeta1*0301 molecule renders it protection-inducing
por: Salazar, Luz M., et al.
Publicado: (2004)

Gauche+ side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine
por: "Bermúdez, Adriana, et al.
Publicado: (2014)

Plasmodium falciparum TryThrA antigen synthetic peptides block in vitro merozoite invasion to erythrocytes
por: Curtidor, Hernando, et al.
Publicado: (2006)

IMPIPS : The Immune Protection-Inducing Protein Structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine development
por: Patarroyo, Manuel Elkin, et al.
Publicado: (2015)

Towards a poly-functional synthetic-antimalarial vaccine: Incorporating non-natural elements into artificially-made peptides for mimicking functional pathogen ligand structures representing new site-directed vaccine components
por: Lozano J.M., et al.
Publicado: (2013)

Quantum chemical analysis of MHC-peptide interactions for vaccine design
por: "Agudelo, W.A, et al.
Publicado: (2010)

Elongating modified conserved peptides eliminates their immunogenicity and protective efficacy against P. falciparum malaria
por: Espejo, Fabiola, et al.
Publicado: (2005)

TCR-contacting residues orientation and HLA-DR?* binding preference determine long-lasting protective immunity against malaria
por: "Alba, Martha P., et al.
Publicado: (2016)

"Functional, immunological and three-dimensional analysis of chemically synthesisedsporozoite peptides as components of a fully-effective antimalarial vaccine"
por: Curtidor H., et al.
Publicado: (2011)

3D Analysis of the TCR/pMHCII Complex Formation in Monkeys Vaccinated with the First Peptide Inducing Sterilizing Immunity against Human Malaria
por: Patarroyo, Manuel A., et al.
Publicado: (2010)

3D structure determination of STARP peptides implicated in P. falciparum invasion of hepatic cells
por: Bermúdez, Adriana, et al.
Publicado: (2010)

What is known about the immune response induced by Plasmodium vivax malaria vaccine candidates?
por: López, Carolina, et al.
Publicado: (2017)

Using the PfEMP1 Head Structure Binding Motif to Deal a Blow at Severe Malaria
por: Patarroyo, Manuel E., et al.
Publicado: (2014)

MAEBL Plasmodium falciparum protein peptides bind specifically to erythrocytes and inhibit in vitro merozoite invasion
por: Ocampo,Marisol, et al.
Publicado: (2004)

Atomic evidence that modification of H-bonds established with amino acids critical for host-cell binding induces sterile immunity against malaria
por: "Patarroyo, Manuel E., et al.
Publicado: (2010)

Cryptosporidium spp. CP15 and CSL protein-derived synthetic peptides’ immunogenicity and in vitro seroneutralisation capability
por: Avendaño C., et al.
Publicado: (2018)

The high immunogenicity induced by modified sporozoites' malarial peptides depends on their phi (?) and psi (?) angles
por: "Patarroyo, Manuel E., et al.
Publicado: (2012)

Protective immunity provided by a new modified SERA protein peptide: Its immunogenetic characteristics and correlation with 3D structure
por: Bermúdez, Adriana, et al.
Publicado: (2012)

"Emerging rules for subunit-based, multiantigenic, multistage chemically synthesized vaccines"
por: Patarroyo M.E., et al.
Publicado: (2008)