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Peptide Vaccines for Malaria

Obtaining a highly effective malaria vaccine is a worldwide priority. The first approach aimed at obtaining a malarial vaccine using synthetic peptides was a polymeric chimeric molecule named SPf66, which conferred limited protective efficacy in Aotus monkeys and in large human field-trials. Our eff...

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Detalles Bibliográficos
Autores Principales: Bermudez Quintero, Adriana Janneth, Lozano Moreno, Jose Manuel, Patarroyo, Manuel Elkin
Formato: Capítulo de libro (Book Chapter)
Lenguaje:Inglés (English)
Publicado: Elsevier 2006
Materias:
Peptide Vaccines for Malaria
Main Malarial Antigens
MHC II-peptide-TCR
Acceso en línea:https://repository.urosario.edu.co/handle/10336/28828
https://doi.org/10.1016/B978-012369442-3/50077-5
id ir-10336-28828
recordtype dspace
spelling ir-10336-288282020-08-28T15:49:52Z Peptide Vaccines for Malaria Vacunas peptídicas para la malaria Bermudez Quintero, Adriana Janneth Lozano Moreno, Jose Manuel Patarroyo, Manuel Elkin Peptide Vaccines for Malaria Main Malarial Antigens MHC II-peptide-TCR Obtaining a highly effective malaria vaccine is a worldwide priority. The first approach aimed at obtaining a malarial vaccine using synthetic peptides was a polymeric chimeric molecule named SPf66, which conferred limited protective efficacy in Aotus monkeys and in large human field-trials. Our efforts then became focused on obtaining a second generation malarial vaccine based on the rational selection of conserved high activity binding peptides (HABPs) whose critical binding residues were to be systematically replaced by others precisely selected. An alternative approach has consisted of replacing peptide bonds involving these HABPs’ critical binding residues; this has also returned promising results to date. Our overall results have suggested a correlation between modified HABPs’ three-dimensional structure, HLA-DR ?1* binding preferences, and their protection-inducing capacity in monkeys. Basic knowledge of a parasite's functionally active peptides, their 3D structure, and their interaction for forming the MHC II-peptide-TCR complex will thus contribute toward designing fully effective multicomponent, multistage, subunit-based malarial vaccines. 2006-01-01 2020-08-28T15:49:52Z info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion ISBN: 978-0-12-369442-3 https://repository.urosario.edu.co/handle/10336/28828 https://doi.org/10.1016/B978-012369442-3/50077-5 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Handbook of Biologically Active Peptides
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Peptide Vaccines for Malaria
Main Malarial Antigens
MHC II-peptide-TCR
spellingShingle Peptide Vaccines for Malaria
Main Malarial Antigens
MHC II-peptide-TCR
Bermudez Quintero, Adriana Janneth
Lozano Moreno, Jose Manuel
Patarroyo, Manuel Elkin
Peptide Vaccines for Malaria
description Obtaining a highly effective malaria vaccine is a worldwide priority. The first approach aimed at obtaining a malarial vaccine using synthetic peptides was a polymeric chimeric molecule named SPf66, which conferred limited protective efficacy in Aotus monkeys and in large human field-trials. Our efforts then became focused on obtaining a second generation malarial vaccine based on the rational selection of conserved high activity binding peptides (HABPs) whose critical binding residues were to be systematically replaced by others precisely selected. An alternative approach has consisted of replacing peptide bonds involving these HABPs’ critical binding residues; this has also returned promising results to date. Our overall results have suggested a correlation between modified HABPs’ three-dimensional structure, HLA-DR ?1* binding preferences, and their protection-inducing capacity in monkeys. Basic knowledge of a parasite's functionally active peptides, their 3D structure, and their interaction for forming the MHC II-peptide-TCR complex will thus contribute toward designing fully effective multicomponent, multistage, subunit-based malarial vaccines.
format Capítulo de libro (Book Chapter)
author Bermudez Quintero, Adriana Janneth
Lozano Moreno, Jose Manuel
Patarroyo, Manuel Elkin
author_facet Bermudez Quintero, Adriana Janneth
Lozano Moreno, Jose Manuel
Patarroyo, Manuel Elkin
author_sort Bermudez Quintero, Adriana Janneth
title Peptide Vaccines for Malaria
title_short Peptide Vaccines for Malaria
title_full Peptide Vaccines for Malaria
title_fullStr Peptide Vaccines for Malaria
title_full_unstemmed Peptide Vaccines for Malaria
title_sort peptide vaccines for malaria
publisher Elsevier
publishDate 2006
url https://repository.urosario.edu.co/handle/10336/28828
https://doi.org/10.1016/B978-012369442-3/50077-5
_version_ 1676708452194320384
score 11,383075

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