Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects

Chagas disease or American trypanosomiasis is a pathology affecting about 8–11 million people in Mexico, Central America, and South America, more than 300 000 persons in the United States as well as an indeterminate number of people in other non-endemic countries such as USA, Spain, Canada and Switz...

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Autores Principales: Sánchez, Laura Viviana, Ramírez, Juan David
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Cambridge University Press 2013
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/28482
https://doi.org/10.1017/S0031182012001394
id ir-10336-28482
recordtype dspace
spelling ir-10336-284822020-08-28T15:48:17Z Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects Transmisión congénita y oral de la tripanosomiasis americana: una descripción general de los aspectos fisiopatogénicos Sánchez, Laura Viviana Ramírez, Juan David Immune response Trypanosoma cruzi Oral chagas disease Congenital chagas disease Chagas disease or American trypanosomiasis is a pathology affecting about 8–11 million people in Mexico, Central America, and South America, more than 300 000 persons in the United States as well as an indeterminate number of people in other non-endemic countries such as USA, Spain, Canada and Switzerland. The aetiological agent is Trypanosoma cruzi, a protozoan transmitted by multiple routes; among them, congenital route emerges as one of the most important mechanisms of spreading Chagas disease worldwide even in non-endemic countries and the oral route as the responsible of multiple outbreaks of acute Chagas disease in regions where the vectorial route has been interrupted. The aim of this review is to illustrate the recent research and advances in host-pathogen interaction making a model of how the virulence factors of the parasite would interact with the physiology and immune system components of the placental barrier and gastrointestinal tract in order to establish a response against T. cruzi infection. This review also presents the epidemiological, clinical and diagnostic features of congenital and oral Chagas disease in order to update the reader about the emerging scenarios of Chagas disease transmission. 2013-02 2020-08-28T15:48:17Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0031-1820 EISSN: 1469-8161 https://repository.urosario.edu.co/handle/10336/28482 https://doi.org/10.1017/S0031182012001394 eng info:eu-repo/semantics/restrictedAccess application/pdf Cambridge University Press Parasitology
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Immune response
Trypanosoma cruzi
Oral chagas disease
Congenital chagas disease
spellingShingle Immune response
Trypanosoma cruzi
Oral chagas disease
Congenital chagas disease
Sánchez, Laura Viviana
Ramírez, Juan David
Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects
description Chagas disease or American trypanosomiasis is a pathology affecting about 8–11 million people in Mexico, Central America, and South America, more than 300 000 persons in the United States as well as an indeterminate number of people in other non-endemic countries such as USA, Spain, Canada and Switzerland. The aetiological agent is Trypanosoma cruzi, a protozoan transmitted by multiple routes; among them, congenital route emerges as one of the most important mechanisms of spreading Chagas disease worldwide even in non-endemic countries and the oral route as the responsible of multiple outbreaks of acute Chagas disease in regions where the vectorial route has been interrupted. The aim of this review is to illustrate the recent research and advances in host-pathogen interaction making a model of how the virulence factors of the parasite would interact with the physiology and immune system components of the placental barrier and gastrointestinal tract in order to establish a response against T. cruzi infection. This review also presents the epidemiological, clinical and diagnostic features of congenital and oral Chagas disease in order to update the reader about the emerging scenarios of Chagas disease transmission.
format Artículo (Article)
author Sánchez, Laura Viviana
Ramírez, Juan David
author_facet Sánchez, Laura Viviana
Ramírez, Juan David
author_sort Sánchez, Laura Viviana
title Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects
title_short Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects
title_full Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects
title_fullStr Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects
title_full_unstemmed Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects
title_sort congenital and oral transmission of american trypanosomiasis: an overview of physiopathogenic aspects
publisher Cambridge University Press
publishDate 2013
url https://repository.urosario.edu.co/handle/10336/28482
https://doi.org/10.1017/S0031182012001394
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score 11,382149