Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism

"Objective. To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren’s syndrome (pSS). Methods. Serum IL-10 and...

Descripción completa

Detalles Bibliográficos
Autores Principales: Anaya, Juan Manuel, Correa Paula A., Herrera, Monica, Eskdale, Joyce, Gallagher, Grant
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: The journal of rheumatology 2002
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/27893
id ir-10336-27893
recordtype dspace
spelling ir-10336-278932020-08-19T14:44:29Z Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism La interleucina 10 (IL-10) influye en la respuesta autoinmune en el síndrome de Sjögren primario y está relacionada con el polimorfismo del gen IL-10 Anaya, Juan Manuel Correa Paula A. Herrera, Monica Eskdale, Joyce Gallagher, Grant Sjögren’s Syndrome Interleukin 10 Anti-Ro Antibodies Anti-La Antibodies Rheumatoid Factor Polymorphism Genetics "Objective. To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren’s syndrome (pSS). Methods. Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. Results. IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 ± 6.7 vs 2.5 ± 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (< 9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. Conclusion. Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism. (J Rheumatol 2002;29:1874–6)." 2002 2020-08-19T14:44:29Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0315-162X EISSN: 1499-2752 https://repository.urosario.edu.co/handle/10336/27893 eng info:eu-repo/semantics/openAccess application/pdf The journal of rheumatology Journal of Rheumatology
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Sjögren’s Syndrome
Interleukin 10
Anti-Ro Antibodies
Anti-La Antibodies
Rheumatoid Factor
Polymorphism Genetics
spellingShingle Sjögren’s Syndrome
Interleukin 10
Anti-Ro Antibodies
Anti-La Antibodies
Rheumatoid Factor
Polymorphism Genetics
Anaya, Juan Manuel
Correa Paula A.
Herrera, Monica
Eskdale, Joyce
Gallagher, Grant
Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism
description "Objective. To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren’s syndrome (pSS). Methods. Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. Results. IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 ± 6.7 vs 2.5 ± 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (< 9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. Conclusion. Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism. (J Rheumatol 2002;29:1874–6)."
format Artículo (Article)
author Anaya, Juan Manuel
Correa Paula A.
Herrera, Monica
Eskdale, Joyce
Gallagher, Grant
author_facet Anaya, Juan Manuel
Correa Paula A.
Herrera, Monica
Eskdale, Joyce
Gallagher, Grant
author_sort Anaya, Juan Manuel
title Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism
title_short Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism
title_full Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism
title_fullStr Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism
title_full_unstemmed Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism
title_sort interleukin 10 (il-10) influences autoimmune response in primary sjögren's syndrome and is linked to il-10 gene polymorphism
publisher The journal of rheumatology
publishDate 2002
url https://repository.urosario.edu.co/handle/10336/27893
_version_ 1676074175625691136
score 11,828437