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Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.

"The protein called serine repeat antigen (SERA) is a Plasmodium falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic and non-protective), was analyzed for immunogenicity and protective activ...

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Autores Principales: Alaba, Martha Patricia, Salazar, Luz Mary, Purmova, Jindra, Vanegas, Magnolia, Rodriguez, Raul, Patarroyo, Manuel Elkin
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Elsevier 2004
Materias:
Peptide
Malaria
SERA
NMR
Acceso en línea:https://repository.urosario.edu.co/handle/10336/27865
https://doi.org/10.1016/j.vaccine.2003.08.046
id ir-10336-27865
recordtype dspace
spelling ir-10336-278652020-08-19T14:46:27Z Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria. La inducción y el desplazamiento de una hélice en el análogo del péptido SERA 6725 confiere protección contra la malaria por P. falciparum. Alaba, Martha Patricia Salazar, Luz Mary Purmova, Jindra Vanegas, Magnolia Rodriguez, Raul Patarroyo, Manuel Elkin Peptide Malaria SERA NMR "The protein called serine repeat antigen (SERA) is a Plasmodium falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic and non-protective), was analyzed for immunogenicity and protective activity in Aotus monkeys, together with several of its analogues. These peptides were studied by 1H NMR to try to correlate their structure with their biological function. These peptides showed helical regions having differences in their position, except for randomly structured 6725. It is shown that replacing some amino acids induced immunogenicity and protectivity against experimental malaria and changed their three-dimensional (3D) structure, suggesting that such modifications may allow a better fit with immune system molecules." 2004 2020-08-19T14:44:19Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0264-410X EISSN: 1873-2518 https://repository.urosario.edu.co/handle/10336/27865 https://doi.org/10.1016/j.vaccine.2003.08.046 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Vaccine
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Peptide
Malaria
SERA
NMR
spellingShingle Peptide
Malaria
SERA
NMR
Alaba, Martha Patricia
Salazar, Luz Mary
Purmova, Jindra
Vanegas, Magnolia
Rodriguez, Raul
Patarroyo, Manuel Elkin
Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
description "The protein called serine repeat antigen (SERA) is a Plasmodium falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic and non-protective), was analyzed for immunogenicity and protective activity in Aotus monkeys, together with several of its analogues. These peptides were studied by 1H NMR to try to correlate their structure with their biological function. These peptides showed helical regions having differences in their position, except for randomly structured 6725. It is shown that replacing some amino acids induced immunogenicity and protectivity against experimental malaria and changed their three-dimensional (3D) structure, suggesting that such modifications may allow a better fit with immune system molecules."
format Artículo (Article)
author Alaba, Martha Patricia
Salazar, Luz Mary
Purmova, Jindra
Vanegas, Magnolia
Rodriguez, Raul
Patarroyo, Manuel Elkin
author_facet Alaba, Martha Patricia
Salazar, Luz Mary
Purmova, Jindra
Vanegas, Magnolia
Rodriguez, Raul
Patarroyo, Manuel Elkin
author_sort Alaba, Martha Patricia
title Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
title_short Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
title_full Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
title_fullStr Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
title_full_unstemmed Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
title_sort induction and displacement of an helix in the 6725 sera peptide analogue confers protection against p. falciparum malaria.
publisher Elsevier
publishDate 2004
url https://repository.urosario.edu.co/handle/10336/27865
https://doi.org/10.1016/j.vaccine.2003.08.046
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score 11,381624

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