Human polymorphism at microRNAs and microRNA target sites

MicroRNAs (miRNAs) function as endogenous translational repressors of protein-coding genes in animals by binding to target sites in the 3? UTRs of mRNAs. Because a single nucleotide change in the sequence of a target site can affect miRNA regulation, naturally occurring SNPs in target sites are cand...

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Detalles Bibliográficos
Autores Principales: Saunders, Matthew A., Liang, Han, Li, Wen-Hsiung
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: National Academy of Sciences 2007
Acceso en línea: