Gastrointestinal-associated autoantibodies in different autoimmune diseases

Background: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID. Methods: We examined...

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Autores Principales: Anaya, Juan Manuel, Bizzaro, Nicolas, Tincani, Angela, Espinosa, Gerard, Villalta, Danilo, Cervera, Ricard
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: National Library of Medicine 2012
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Acceso en línea:https://repository.urosario.edu.co/handle/10336/27765
id ir-10336-27765
recordtype dspace
spelling ir-10336-277652020-08-19T14:46:32Z Gastrointestinal-associated autoantibodies in different autoimmune diseases Autoanticuerpos asociados al tubo digestivo en diferentes enfermedades autoinmunes Anaya, Juan Manuel Bizzaro, Nicolas Tincani, Angela Espinosa, Gerard Villalta, Danilo Cervera, Ricard Gliadin (AGA) Tissue-transglutaminase (tTG) Saccharomyces cerevisiae (ASCA) Autoantibodies Inflammatory bowel diseases. Background: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID. Methods: We examined 923 serum samples representing 18 AID and compared them with 338 samples from healthy subjects. We used the BioPlex 2200-immunoassay (Bio-Rad, USA) to test samples for the presence of IgA and IgG directed at gliadin (AGA), tissue-transglutaminase (tTG), and Saccharomyces cerevisiae (ASCA). Results: Prevalence of IgA AGA was significantly higher in antiphospholipid syndrome (APS) (7.1 %, P=0.012) and in pemphigus vulgaris (25%, P =0.008) patients, as compared with healthy controls. Presence of IgG-AGA was more common among Crohn’s disease (20.5%, P = 0.023) and rheumatoid arthritis (6.5%, P=0.027) patients. IgG anti tTG were frequently observed in APS (6.1%, P=0.012), in giant cell arteritis (11.5%, P=0.013) and in ulcerative colitis (11.1%, P=0.018) patients, and as expected, higher prevalence of ASCA (IgA 19.3% and IgG 27.7%) was found in Crohn’s disease. IgG ASCA were also found in systemic lupus erythematosus (SLE) (4.5%, P=0.01), in Graves’ disease (5.7%, P=0.018), in cryoglobulinemia (7.1%, P=0.006), and in patients with vasculitides (6.5%, P=0.002). In contrast, lower prevalence of IgG type AGA was found in SLE (P=0.034), cryoglobulinemia (P=0.019) and vasculitides (P=0.013) patients. Conclusions: Our findings suggest an association between GI-related- Abs and a wide spectrum of AID. The clinical implication of these findings is yet to be determined. 2012-05-25 2020-08-19T14:43:45Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion EISSN: 2164-7712 https://repository.urosario.edu.co/handle/10336/27765 eng info:eu-repo/semantics/openAccess application/pdf National Library of Medicine American Journal of Clinical and Experimental Immunology
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Gliadin (AGA)
Tissue-transglutaminase (tTG)
Saccharomyces cerevisiae (ASCA)
Autoantibodies
Inflammatory bowel diseases.
spellingShingle Gliadin (AGA)
Tissue-transglutaminase (tTG)
Saccharomyces cerevisiae (ASCA)
Autoantibodies
Inflammatory bowel diseases.
Anaya, Juan Manuel
Bizzaro, Nicolas
Tincani, Angela
Espinosa, Gerard
Villalta, Danilo
Cervera, Ricard
Gastrointestinal-associated autoantibodies in different autoimmune diseases
description Background: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID. Methods: We examined 923 serum samples representing 18 AID and compared them with 338 samples from healthy subjects. We used the BioPlex 2200-immunoassay (Bio-Rad, USA) to test samples for the presence of IgA and IgG directed at gliadin (AGA), tissue-transglutaminase (tTG), and Saccharomyces cerevisiae (ASCA). Results: Prevalence of IgA AGA was significantly higher in antiphospholipid syndrome (APS) (7.1 %, P=0.012) and in pemphigus vulgaris (25%, P =0.008) patients, as compared with healthy controls. Presence of IgG-AGA was more common among Crohn’s disease (20.5%, P = 0.023) and rheumatoid arthritis (6.5%, P=0.027) patients. IgG anti tTG were frequently observed in APS (6.1%, P=0.012), in giant cell arteritis (11.5%, P=0.013) and in ulcerative colitis (11.1%, P=0.018) patients, and as expected, higher prevalence of ASCA (IgA 19.3% and IgG 27.7%) was found in Crohn’s disease. IgG ASCA were also found in systemic lupus erythematosus (SLE) (4.5%, P=0.01), in Graves’ disease (5.7%, P=0.018), in cryoglobulinemia (7.1%, P=0.006), and in patients with vasculitides (6.5%, P=0.002). In contrast, lower prevalence of IgG type AGA was found in SLE (P=0.034), cryoglobulinemia (P=0.019) and vasculitides (P=0.013) patients. Conclusions: Our findings suggest an association between GI-related- Abs and a wide spectrum of AID. The clinical implication of these findings is yet to be determined.
format Artículo (Article)
author Anaya, Juan Manuel
Bizzaro, Nicolas
Tincani, Angela
Espinosa, Gerard
Villalta, Danilo
Cervera, Ricard
author_facet Anaya, Juan Manuel
Bizzaro, Nicolas
Tincani, Angela
Espinosa, Gerard
Villalta, Danilo
Cervera, Ricard
author_sort Anaya, Juan Manuel
title Gastrointestinal-associated autoantibodies in different autoimmune diseases
title_short Gastrointestinal-associated autoantibodies in different autoimmune diseases
title_full Gastrointestinal-associated autoantibodies in different autoimmune diseases
title_fullStr Gastrointestinal-associated autoantibodies in different autoimmune diseases
title_full_unstemmed Gastrointestinal-associated autoantibodies in different autoimmune diseases
title_sort gastrointestinal-associated autoantibodies in different autoimmune diseases
publisher National Library of Medicine
publishDate 2012
url https://repository.urosario.edu.co/handle/10336/27765
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score 11,392632