Exercise dose-response of the V? E/V?CO 2 slope in postmenopausal women in the DREW study

"Purpose: Being overweight/obese, having hypertension, and being postmenopausal are risk factors for the development of congestive heart failure (CHF). A characteristic of CHF is an abnormal V?E/V?CO2 slope, which is predictive of mortality in patients with CHF. Although the V?E/V?CO2 slope is...

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Autores Principales: Anaya, Stephanie A., Church, Timothy S., Blair, Steven N., Myers, Jonathan N., Earnest, Conrad P.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: American College of Sports Medicine 2009
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/27702
https://doi.org/10.1249/MSS.0b013e3181930009
id ir-10336-27702
recordtype dspace
spelling ir-10336-277022020-08-19T14:43:25Z Exercise dose-response of the V? E/V?CO 2 slope in postmenopausal women in the DREW study Ejercicio dosis-respuesta de la pendiente V? E / V?CO 2 en mujeres posmenopáusicas en el estudio DREW Anaya, Stephanie A. Church, Timothy S. Blair, Steven N. Myers, Jonathan N. Earnest, Conrad P. Blood pressure Sedentary Ventilatory efficiency Cardiorespiratory fitness "Purpose: Being overweight/obese, having hypertension, and being postmenopausal are risk factors for the development of congestive heart failure (CHF). A characteristic of CHF is an abnormal V?E/V?CO2 slope, which is predictive of mortality in patients with CHF. Although the V?E/V?CO2 slope is well established in CHF patients, little is known regarding interventions for ""at-risk"" populations. Methods: We examined the V?E/V?CO2 slope in 401 sedentary, overweight, moderately hypertensive women randomized to 6 m of nonexercise (control) or 4 kcal·kg?1·wk?1 (KKW), 8 KKW, or 12 KKW of exercise at an intensity corresponding to 50% of baseline V?O2max. We examined trends in exercise treatment dose versus change in mean V?E/V?CO2 slope using a linear regression model (KKW vs V?E/V?CO2 slope) and a linear mixed model. Results: Regression analysis showed a significant trend for a reduction in the V?E/V?CO2 slope from baseline (mean ± SD: 32.6 ± 6.3; P < 0.004). When expressed as mean change (95% confidence interval (CI)) from baseline, we observed significant reductions in the V?E/V?CO2 slope for the 8-KKW (?1.14; 95% CI, ?1.5 to ?0.2) and 12-KKW (?1.67; 95% CI, ?2.3 to ?0.3) groups. No significant effect was noted for the 4-KKW (?0.4; 95% CI, ?1.2 to 0.15) group. Conclusion: Moderate-intensity aerobic exercise at doses of 8 KKW or greater seems to present an adequate dose of exercise to promote small but significant reductions in the V?E/V?CO2 slope in postmenopausal women who exhibit risk factors associated with the development of CHF." 2009-05 2020-08-19T14:43:25Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0195-9131 EISSN: 1530-0315 https://repository.urosario.edu.co/handle/10336/27702 https://doi.org/10.1249/MSS.0b013e3181930009 eng info:eu-repo/semantics/openAccess application/pdf American College of Sports Medicine Medicine and Science in Sports and Exercise
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Blood pressure
Sedentary
Ventilatory efficiency
Cardiorespiratory fitness
spellingShingle Blood pressure
Sedentary
Ventilatory efficiency
Cardiorespiratory fitness
Anaya, Stephanie A.
Church, Timothy S.
Blair, Steven N.
Myers, Jonathan N.
Earnest, Conrad P.
Exercise dose-response of the V? E/V?CO 2 slope in postmenopausal women in the DREW study
description "Purpose: Being overweight/obese, having hypertension, and being postmenopausal are risk factors for the development of congestive heart failure (CHF). A characteristic of CHF is an abnormal V?E/V?CO2 slope, which is predictive of mortality in patients with CHF. Although the V?E/V?CO2 slope is well established in CHF patients, little is known regarding interventions for ""at-risk"" populations. Methods: We examined the V?E/V?CO2 slope in 401 sedentary, overweight, moderately hypertensive women randomized to 6 m of nonexercise (control) or 4 kcal·kg?1·wk?1 (KKW), 8 KKW, or 12 KKW of exercise at an intensity corresponding to 50% of baseline V?O2max. We examined trends in exercise treatment dose versus change in mean V?E/V?CO2 slope using a linear regression model (KKW vs V?E/V?CO2 slope) and a linear mixed model. Results: Regression analysis showed a significant trend for a reduction in the V?E/V?CO2 slope from baseline (mean ± SD: 32.6 ± 6.3; P < 0.004). When expressed as mean change (95% confidence interval (CI)) from baseline, we observed significant reductions in the V?E/V?CO2 slope for the 8-KKW (?1.14; 95% CI, ?1.5 to ?0.2) and 12-KKW (?1.67; 95% CI, ?2.3 to ?0.3) groups. No significant effect was noted for the 4-KKW (?0.4; 95% CI, ?1.2 to 0.15) group. Conclusion: Moderate-intensity aerobic exercise at doses of 8 KKW or greater seems to present an adequate dose of exercise to promote small but significant reductions in the V?E/V?CO2 slope in postmenopausal women who exhibit risk factors associated with the development of CHF."
format Artículo (Article)
author Anaya, Stephanie A.
Church, Timothy S.
Blair, Steven N.
Myers, Jonathan N.
Earnest, Conrad P.
author_facet Anaya, Stephanie A.
Church, Timothy S.
Blair, Steven N.
Myers, Jonathan N.
Earnest, Conrad P.
author_sort Anaya, Stephanie A.
title Exercise dose-response of the V? E/V?CO 2 slope in postmenopausal women in the DREW study
title_short Exercise dose-response of the V? E/V?CO 2 slope in postmenopausal women in the DREW study
title_full Exercise dose-response of the V? E/V?CO 2 slope in postmenopausal women in the DREW study
title_fullStr Exercise dose-response of the V? E/V?CO 2 slope in postmenopausal women in the DREW study
title_full_unstemmed Exercise dose-response of the V? E/V?CO 2 slope in postmenopausal women in the DREW study
title_sort exercise dose-response of the v? e/v?co 2 slope in postmenopausal women in the drew study
publisher American College of Sports Medicine
publishDate 2009
url https://repository.urosario.edu.co/handle/10336/27702
https://doi.org/10.1249/MSS.0b013e3181930009
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score 11,383075