Effect of etodolac on methotrexate pharmacokinetics in patients with rheumatoid arthritis

OBJECTIVE: To determine if the pharmacokinetics of methotrexate (MTX) is modified by the coadministration of etodolac. METHODS: MTX (10 mg) was administered intramuscularly in the absence and presence of steady state levels of etodolac in 19 patients with rheumatoid arthritis. MTX levels were assaye...

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Detalles Bibliográficos
Autores Principales: Anaya, Juan-Manuel, Fabre, D., Bressolle, F., Bologna, C., Alric R., Cocciglio, M.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Europe PMC 1991
Acceso en línea:https://repository.urosario.edu.co/handle/10336/27572