Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients

To determine the correlation between the pharmacokinetic (PK) parameters of methotrexate (MTX), clinical status and laboratory test results in rheumatoid arthritis (RA) patients.22 patients (4 M/18F, mean age: 50 +/- 12 years, mean duration of RA: 8.5 +/- 6.5 years, mean duration on MTX: 8 +/- 10 mo...

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Autores Principales: Anaya, Juan-Manuel, Bologna, C., Jorgensen, C., Alric, R, Sany, J.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Europe PMC 1995
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/27434
id ir-10336-27434
recordtype dspace
spelling ir-10336-274342021-08-10T21:56:01Z Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients Correlación entre los parámetros farmacocinéticos del metotrexato y el estado clínico y biológico en pacientes con artritis reumatoide Anaya, Juan-Manuel Bologna, C. Jorgensen, C. Alric, R Sany, J. Pharmacokinetic Rheumatoid arthritis To determine the correlation between the pharmacokinetic (PK) parameters of methotrexate (MTX), clinical status and laboratory test results in rheumatoid arthritis (RA) patients.22 patients (4 M/18F, mean age: 50 +/- 12 years, mean duration of RA: 8.5 +/- 6.5 years, mean duration on MTX: 8 +/- 10 months) were included in a prospective study. The mean dose of MTX administered was 6 +/- 0.7 mg/m2 of body area/week. No patient received any nonsteroidal antiinflammatory drug (NSAID). Blood and urine samples were collected over 24 hours (9 blood samples). The MTX concentrations were assayed by fluorescence polarization immunoassay. Clinical parameters (Ritchie articular index, morning stiffness, joint pain count, joint swelling count), hematological, liver and renal function tests, and ESR were recorded. Correlations between the patients' PK parameters, laboratory tests and clinical status were carried out using Pearson's correlation coefficient test.A significant correlation was observed between the Ritchie articular index, morning stiffness and the area under the curve (p = 0.009 and p = 0.026, respectively). No correlation was found with the other parameters.These results suggest that when the patient's disease activity is higher, the AUC becomes more important, reflecting a greater body exposure to MTX. 1995 2020-08-19T14:42:11Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0392-856X EISSN: 1593-098X https://repository.urosario.edu.co/handle/10336/27434 eng info:eu-repo/semantics/closedAccess application/pdf Europe PMC Clinical and Experimental Rheumatology
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Pharmacokinetic
Rheumatoid arthritis
spellingShingle Pharmacokinetic
Rheumatoid arthritis
Anaya, Juan-Manuel
Bologna, C.
Jorgensen, C.
Alric, R
Sany, J.
Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients
description To determine the correlation between the pharmacokinetic (PK) parameters of methotrexate (MTX), clinical status and laboratory test results in rheumatoid arthritis (RA) patients.22 patients (4 M/18F, mean age: 50 +/- 12 years, mean duration of RA: 8.5 +/- 6.5 years, mean duration on MTX: 8 +/- 10 months) were included in a prospective study. The mean dose of MTX administered was 6 +/- 0.7 mg/m2 of body area/week. No patient received any nonsteroidal antiinflammatory drug (NSAID). Blood and urine samples were collected over 24 hours (9 blood samples). The MTX concentrations were assayed by fluorescence polarization immunoassay. Clinical parameters (Ritchie articular index, morning stiffness, joint pain count, joint swelling count), hematological, liver and renal function tests, and ESR were recorded. Correlations between the patients' PK parameters, laboratory tests and clinical status were carried out using Pearson's correlation coefficient test.A significant correlation was observed between the Ritchie articular index, morning stiffness and the area under the curve (p = 0.009 and p = 0.026, respectively). No correlation was found with the other parameters.These results suggest that when the patient's disease activity is higher, the AUC becomes more important, reflecting a greater body exposure to MTX.
format Artículo (Article)
author Anaya, Juan-Manuel
Bologna, C.
Jorgensen, C.
Alric, R
Sany, J.
author_facet Anaya, Juan-Manuel
Bologna, C.
Jorgensen, C.
Alric, R
Sany, J.
author_sort Anaya, Juan-Manuel
title Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients
title_short Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients
title_full Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients
title_fullStr Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients
title_full_unstemmed Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients
title_sort correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients
publisher Europe PMC
publishDate 1995
url https://repository.urosario.edu.co/handle/10336/27434
_version_ 1712098552372527104
score 12,131701