Autoimmunity and tuberculosis. Opposite association with TNF polymorphism.

Objective. To examine the influence of the –308 and –238 single nucleotide polymorphisms (SNP) of tumor necrosis factor-? gene (TNF) on patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren’s syndrome (SS), and tuberculosis (TB). Methods. Genomic DNA from patie...

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Autores Principales: Anaya, Juan Manuel, Correa, Paula A., Gomez, Luis M., Cadena, Jose
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Instituto Nacional de Salud 2005
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/27270
id ir-10336-27270
recordtype dspace
spelling ir-10336-272702020-08-19T14:46:57Z Autoimmunity and tuberculosis. Opposite association with TNF polymorphism. Autoinmunidad y tuberculosis. Asociación opuesta con polimorfismo de TNF. Anaya, Juan Manuel Correa, Paula A. Gomez, Luis M. Cadena, Jose Tumor Necrosis Factor Rheumatoid Arthritis Tuberculosis Systemic Lupus Erythematosus Sjögren’s Syndrome Autoimmunity Objective. To examine the influence of the –308 and –238 single nucleotide polymorphisms (SNP) of tumor necrosis factor-? gene (TNF) on patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren’s syndrome (SS), and tuberculosis (TB). Methods. Genomic DNA from patients with RA (n = 165), SLE (n = 100), primary SS (n = 67), and TB (n = 135) and ethnically matched controls (n = 430) was genotyped for TNF –308 and –238 SNP by PCR-RFLP. Results. TNF –308A allele was associated with RA (odds ratio, OR 1.8, p = 0.002), SLE (OR 2.6, p < 0.0001), and primary SS (OR 2.9, p < 0.0001). TNF –308G was associated with TB (OR 1.8, p = 0.02). The –308 GG genotype was protective for autoimmunity (p < 0.003). TNF –238A allele was protective for autoimmunity but represented a susceptibility factor for TB (OR 2.2, p < 0.0001). Haplotype –308A–238G was a protective factor against TB, whereas it carried susceptibility for RA, SLE, and primary SS (p < 0.0001). Conclusion. The results show an opposite association of TNF polymorphism with autoimmunity and TB, and suggest the existence of heterozygote advantage, sustaining the hypothesis that autoimmune diseases are a consequence of natural selection for enhanced TB resistance. Data also provide genetic evidence supporting the common variants/multiple disease hypothesis, which emphasizes that many disease genes may not be disease-specific, and that similar immunogenetic mechanisms underlie autoimmune diseases. 2005-02 2020-08-19T14:41:33Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0120-4157 EISSN: 2590-7379 https://repository.urosario.edu.co/handle/10336/27270 eng info:eu-repo/semantics/openAccess application/pdf Instituto Nacional de Salud Biomedica. Revista del Instituto Nacional de Salud
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Tumor Necrosis Factor
Rheumatoid Arthritis
Tuberculosis
Systemic Lupus Erythematosus
Sjögren’s Syndrome
Autoimmunity
spellingShingle Tumor Necrosis Factor
Rheumatoid Arthritis
Tuberculosis
Systemic Lupus Erythematosus
Sjögren’s Syndrome
Autoimmunity
Anaya, Juan Manuel
Correa, Paula A.
Gomez, Luis M.
Cadena, Jose
Autoimmunity and tuberculosis. Opposite association with TNF polymorphism.
description Objective. To examine the influence of the –308 and –238 single nucleotide polymorphisms (SNP) of tumor necrosis factor-? gene (TNF) on patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren’s syndrome (SS), and tuberculosis (TB). Methods. Genomic DNA from patients with RA (n = 165), SLE (n = 100), primary SS (n = 67), and TB (n = 135) and ethnically matched controls (n = 430) was genotyped for TNF –308 and –238 SNP by PCR-RFLP. Results. TNF –308A allele was associated with RA (odds ratio, OR 1.8, p = 0.002), SLE (OR 2.6, p < 0.0001), and primary SS (OR 2.9, p < 0.0001). TNF –308G was associated with TB (OR 1.8, p = 0.02). The –308 GG genotype was protective for autoimmunity (p < 0.003). TNF –238A allele was protective for autoimmunity but represented a susceptibility factor for TB (OR 2.2, p < 0.0001). Haplotype –308A–238G was a protective factor against TB, whereas it carried susceptibility for RA, SLE, and primary SS (p < 0.0001). Conclusion. The results show an opposite association of TNF polymorphism with autoimmunity and TB, and suggest the existence of heterozygote advantage, sustaining the hypothesis that autoimmune diseases are a consequence of natural selection for enhanced TB resistance. Data also provide genetic evidence supporting the common variants/multiple disease hypothesis, which emphasizes that many disease genes may not be disease-specific, and that similar immunogenetic mechanisms underlie autoimmune diseases.
format Artículo (Article)
author Anaya, Juan Manuel
Correa, Paula A.
Gomez, Luis M.
Cadena, Jose
author_facet Anaya, Juan Manuel
Correa, Paula A.
Gomez, Luis M.
Cadena, Jose
author_sort Anaya, Juan Manuel
title Autoimmunity and tuberculosis. Opposite association with TNF polymorphism.
title_short Autoimmunity and tuberculosis. Opposite association with TNF polymorphism.
title_full Autoimmunity and tuberculosis. Opposite association with TNF polymorphism.
title_fullStr Autoimmunity and tuberculosis. Opposite association with TNF polymorphism.
title_full_unstemmed Autoimmunity and tuberculosis. Opposite association with TNF polymorphism.
title_sort autoimmunity and tuberculosis. opposite association with tnf polymorphism.
publisher Instituto Nacional de Salud
publishDate 2005
url https://repository.urosario.edu.co/handle/10336/27270
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score 12,111491