Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry).

Objective. To describe the clinical and immunologic characteristics of a large series of patients with systemic autoimmune diseases (SAD) associated with chronic hepatitis C virus (HCV) infection. Methods. The HISPAMEC Registry is a multicenter international study group dedicated to collecting data...

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Autores Principales: Ramos Casals, Manuel, Muñoz, Sandra, Medina, Francisco, Jara, Luis Javier, Rosas, José, Calvo Alen, Jaime, Brito Zenon, Pilar, Sanchez Tapias, Jose Maria
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: The journal of rheumatology 2009
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/27010
https://doi.org/10.3899/jrheum.080874
id ir-10336-27010
recordtype dspace
spelling ir-10336-270102022-05-02T12:37:21Z Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry). Enfermedades autoinmunes sistémicas en pacientes con infección por el virus de la hepatitis C: caracterización de 1020 casos (Registro HISPAMEC). Ramos Casals, Manuel Muñoz, Sandra Medina, Francisco Jara, Luis Javier Rosas, José Calvo Alen, Jaime Brito Zenon, Pilar Sanchez Tapias, Jose Maria Hepatitis C Virus Sjögren’s Syndrome Systemic Lupus Erythematosus Rheumatoid Arthritis Polyarteritis Nodosa Antiphospholipid Syndrome Lymphoma Objective. To describe the clinical and immunologic characteristics of a large series of patients with systemic autoimmune diseases (SAD) associated with chronic hepatitis C virus (HCV) infection. Methods. The HISPAMEC Registry is a multicenter international study group dedicated to collecting data on patients diagnosed with SAD with serological evidence of chronic HCV infection. The information sources are cases reported by physicians of the HISPAMEC Study Group and periodic surveillance of reported cases by a Medline search updated up to December 31, 2007. Results. One thousand twenty HCV patients with SAD were included in the registry. Patients were reported from Southern Europe (60%), North America (15%), Asia (14%), Northern Europe (9%), South America (1%), and Australia (1%). Countries reporting the most cases were Spain (236 cases), France (222 cases), Italy (144 cases), USA (120 cases), and Japan (95 cases). The most frequently reported SAD were Sjögren’s syndrome (SS; 483 cases), rheumatoid arthritis (RA; 150 cases), systemic lupus erythematosus (SLE; 129 cases), polyarteritis nodosa (78 cases), antiphospholipid syndrome (59 cases), inflammatory myopathies (39 cases), and sarcoidosis (28 cases). Twenty patients had 2 or more SAD. Epidemiological data were available in 677 cases. Four hundred eighty-seven (72%) patients were female and 186 (28%) male, with a mean age of 49.5 ± 1.0 years at SAD diagnosis and 50.5 ± 1.1 years at diagnosis of HCV infection. The main immunologic features were antinuclear antibody (ANA) in 61% of patients, rheumatoid factor (RF) in 57%, hypocomplementemia in 52%, and cryoglobulins in 52%. The main differential aspect between primary and HCV-related SAD was the predominance of cryoglobulinemic-related markers (cryoglobulins, RF, hypocomplementemia) over specific SAD-related markers (anti-ENA antibodies, anti-dsDNA, anti-cyclic citrullinated peptide) in patients with HCV. Conclusion. In the selected cohort, the SAD most commonly reported in association with chronic HCV infection were SS (nearly half the cases), RA and SLE. Nearly two thirds of SAD-HCV cases were reported from the Mediterranean area. In these patients, ANA, RF and cryoglobulins are the predominant immunological features. (First Release April 15 2009; J Rheumatol 2009;36:1442–8; doi:10.3899/jrheum.080874). 2009-01-16 2020-08-19T14:40:45Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0315-162X EISSN: 1499-2752 https://repository.urosario.edu.co/handle/10336/27010 https://doi.org/10.3899/jrheum.080874 eng info:eu-repo/semantics/openAccess application/pdf The journal of rheumatology instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Hepatitis C Virus
Sjögren’s Syndrome
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Polyarteritis Nodosa
Antiphospholipid Syndrome
Lymphoma
spellingShingle Hepatitis C Virus
Sjögren’s Syndrome
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Polyarteritis Nodosa
Antiphospholipid Syndrome
Lymphoma
Ramos Casals, Manuel
Muñoz, Sandra
Medina, Francisco
Jara, Luis Javier
Rosas, José
Calvo Alen, Jaime
Brito Zenon, Pilar
Sanchez Tapias, Jose Maria
Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry).
description Objective. To describe the clinical and immunologic characteristics of a large series of patients with systemic autoimmune diseases (SAD) associated with chronic hepatitis C virus (HCV) infection. Methods. The HISPAMEC Registry is a multicenter international study group dedicated to collecting data on patients diagnosed with SAD with serological evidence of chronic HCV infection. The information sources are cases reported by physicians of the HISPAMEC Study Group and periodic surveillance of reported cases by a Medline search updated up to December 31, 2007. Results. One thousand twenty HCV patients with SAD were included in the registry. Patients were reported from Southern Europe (60%), North America (15%), Asia (14%), Northern Europe (9%), South America (1%), and Australia (1%). Countries reporting the most cases were Spain (236 cases), France (222 cases), Italy (144 cases), USA (120 cases), and Japan (95 cases). The most frequently reported SAD were Sjögren’s syndrome (SS; 483 cases), rheumatoid arthritis (RA; 150 cases), systemic lupus erythematosus (SLE; 129 cases), polyarteritis nodosa (78 cases), antiphospholipid syndrome (59 cases), inflammatory myopathies (39 cases), and sarcoidosis (28 cases). Twenty patients had 2 or more SAD. Epidemiological data were available in 677 cases. Four hundred eighty-seven (72%) patients were female and 186 (28%) male, with a mean age of 49.5 ± 1.0 years at SAD diagnosis and 50.5 ± 1.1 years at diagnosis of HCV infection. The main immunologic features were antinuclear antibody (ANA) in 61% of patients, rheumatoid factor (RF) in 57%, hypocomplementemia in 52%, and cryoglobulins in 52%. The main differential aspect between primary and HCV-related SAD was the predominance of cryoglobulinemic-related markers (cryoglobulins, RF, hypocomplementemia) over specific SAD-related markers (anti-ENA antibodies, anti-dsDNA, anti-cyclic citrullinated peptide) in patients with HCV. Conclusion. In the selected cohort, the SAD most commonly reported in association with chronic HCV infection were SS (nearly half the cases), RA and SLE. Nearly two thirds of SAD-HCV cases were reported from the Mediterranean area. In these patients, ANA, RF and cryoglobulins are the predominant immunological features. (First Release April 15 2009; J Rheumatol 2009;36:1442–8; doi:10.3899/jrheum.080874).
format Artículo (Article)
author Ramos Casals, Manuel
Muñoz, Sandra
Medina, Francisco
Jara, Luis Javier
Rosas, José
Calvo Alen, Jaime
Brito Zenon, Pilar
Sanchez Tapias, Jose Maria
author_facet Ramos Casals, Manuel
Muñoz, Sandra
Medina, Francisco
Jara, Luis Javier
Rosas, José
Calvo Alen, Jaime
Brito Zenon, Pilar
Sanchez Tapias, Jose Maria
author_sort Ramos Casals, Manuel
title Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry).
title_short Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry).
title_full Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry).
title_fullStr Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry).
title_full_unstemmed Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry).
title_sort systemic autoimmune diseases in patients with hepatitis c virus infection: characterization of 1020 cases (the hispamec registry).
publisher The journal of rheumatology
publishDate 2009
url https://repository.urosario.edu.co/handle/10336/27010
https://doi.org/10.3899/jrheum.080874
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