Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes

Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in imm...

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Autores Principales: Puentes, Alvaro, García, Javier, Vera, Ricardo, López, Ramsés, Suarez, Jorge, Rodríguez, Luis, Curtidor, Hernando, Tovar, Diana, Forero, Martha, Bermudez, Adriana, Cortes, Jimena, Urquiza, Mauricio, Patarroyo, Manuel E., Ocampo, Marisol
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: The Japanese Society for Vaccinology 2004
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/26992
https://doi.org/10.1016/j.vaccine.2003.09.029
id ir-10336-26992
recordtype dspace
spelling ir-10336-269922021-06-11T04:36:49Z Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes Los péptidos de plasmodium falciparum del antígeno de la etapa hepática y del esporozoito se unen específicamente a los hepatocitos humanos Puentes, Alvaro García, Javier Vera, Ricardo López, Ramsés Suarez, Jorge Rodríguez, Luis Curtidor, Hernando Tovar, Diana Forero, Martha Bermudez, Adriana Cortes, Jimena Urquiza, Mauricio Patarroyo, Manuel E. Ocampo, Marisol Plasmodium falciparum SALSA protein Binding peptides Critical residues Hepatocyte binding peptides Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSKDEKAQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides’ (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes. 2004-03-12 2020-08-19T14:40:42Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0264-410X EISSN: 1873-2518 https://repository.urosario.edu.co/handle/10336/26992 https://doi.org/10.1016/j.vaccine.2003.09.029 eng info:eu-repo/semantics/restrictedAccess application/pdf The Japanese Society for Vaccinology Elsevier Vaccine
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Plasmodium falciparum
SALSA protein
Binding peptides
Critical residues
Hepatocyte binding peptides
spellingShingle Plasmodium falciparum
SALSA protein
Binding peptides
Critical residues
Hepatocyte binding peptides
Puentes, Alvaro
García, Javier
Vera, Ricardo
López, Ramsés
Suarez, Jorge
Rodríguez, Luis
Curtidor, Hernando
Tovar, Diana
Forero, Martha
Bermudez, Adriana
Cortes, Jimena
Urquiza, Mauricio
Patarroyo, Manuel E.
Ocampo, Marisol
Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
description Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSKDEKAQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides’ (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes.
format Artículo (Article)
author Puentes, Alvaro
García, Javier
Vera, Ricardo
López, Ramsés
Suarez, Jorge
Rodríguez, Luis
Curtidor, Hernando
Tovar, Diana
Forero, Martha
Bermudez, Adriana
Cortes, Jimena
Urquiza, Mauricio
Patarroyo, Manuel E.
Ocampo, Marisol
author_facet Puentes, Alvaro
García, Javier
Vera, Ricardo
López, Ramsés
Suarez, Jorge
Rodríguez, Luis
Curtidor, Hernando
Tovar, Diana
Forero, Martha
Bermudez, Adriana
Cortes, Jimena
Urquiza, Mauricio
Patarroyo, Manuel E.
Ocampo, Marisol
author_sort Puentes, Alvaro
title Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
title_short Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
title_full Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
title_fullStr Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
title_full_unstemmed Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
title_sort sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
publisher The Japanese Society for Vaccinology
publishDate 2004
url https://repository.urosario.edu.co/handle/10336/26992
https://doi.org/10.1016/j.vaccine.2003.09.029
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