Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in imm...
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The Japanese Society for Vaccinology
2004
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Acceso en línea: | https://repository.urosario.edu.co/handle/10336/26992 https://doi.org/10.1016/j.vaccine.2003.09.029 |
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ir-10336-269922021-06-11T04:36:49Z Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes Los péptidos de plasmodium falciparum del antígeno de la etapa hepática y del esporozoito se unen específicamente a los hepatocitos humanos Puentes, Alvaro García, Javier Vera, Ricardo López, Ramsés Suarez, Jorge Rodríguez, Luis Curtidor, Hernando Tovar, Diana Forero, Martha Bermudez, Adriana Cortes, Jimena Urquiza, Mauricio Patarroyo, Manuel E. Ocampo, Marisol Plasmodium falciparum SALSA protein Binding peptides Critical residues Hepatocyte binding peptides Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSKDEKAQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides’ (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes. 2004-03-12 2020-08-19T14:40:42Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0264-410X EISSN: 1873-2518 https://repository.urosario.edu.co/handle/10336/26992 https://doi.org/10.1016/j.vaccine.2003.09.029 eng info:eu-repo/semantics/restrictedAccess application/pdf The Japanese Society for Vaccinology Elsevier Vaccine |
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EdocUR - Universidad del Rosario |
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language |
Inglés (English) |
topic |
Plasmodium falciparum SALSA protein Binding peptides Critical residues Hepatocyte binding peptides |
spellingShingle |
Plasmodium falciparum SALSA protein Binding peptides Critical residues Hepatocyte binding peptides Puentes, Alvaro García, Javier Vera, Ricardo López, Ramsés Suarez, Jorge Rodríguez, Luis Curtidor, Hernando Tovar, Diana Forero, Martha Bermudez, Adriana Cortes, Jimena Urquiza, Mauricio Patarroyo, Manuel E. Ocampo, Marisol Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes |
description |
Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSKDEKAQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides’ (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes. |
format |
Artículo (Article) |
author |
Puentes, Alvaro García, Javier Vera, Ricardo López, Ramsés Suarez, Jorge Rodríguez, Luis Curtidor, Hernando Tovar, Diana Forero, Martha Bermudez, Adriana Cortes, Jimena Urquiza, Mauricio Patarroyo, Manuel E. Ocampo, Marisol |
author_facet |
Puentes, Alvaro García, Javier Vera, Ricardo López, Ramsés Suarez, Jorge Rodríguez, Luis Curtidor, Hernando Tovar, Diana Forero, Martha Bermudez, Adriana Cortes, Jimena Urquiza, Mauricio Patarroyo, Manuel E. Ocampo, Marisol |
author_sort |
Puentes, Alvaro |
title |
Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes |
title_short |
Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes |
title_full |
Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes |
title_fullStr |
Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes |
title_full_unstemmed |
Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes |
title_sort |
sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes |
publisher |
The Japanese Society for Vaccinology |
publishDate |
2004 |
url |
https://repository.urosario.edu.co/handle/10336/26992 https://doi.org/10.1016/j.vaccine.2003.09.029 |
_version_ |
1702626589913645056 |
score |
12,131701 |