Rheumatoid arthritis associated with high levels of immunoglobulin A: Clinical and biological characteristics

We measured the serum immunoglobulins in 191 patients with rheumatoid arthritis (RA) over an 8-month period, looking for a relationship between high IgA levels, disease activity, and clinical and biological features. Twenty-nine patients with a polyclonal hyperimmunoglobulin A (IgA) (15.2%) above 5...

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Autores Principales: Jorgensen, C., Anaya, Juan-Manuel, Cognot, C., Sany, J.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Europe PMC 1992
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Acceso en línea:https://repository.urosario.edu.co/handle/10336/26903
id ir-10336-26903
recordtype dspace
spelling ir-10336-269032021-08-10T22:07:43Z Rheumatoid arthritis associated with high levels of immunoglobulin A: Clinical and biological characteristics Artritis reumatoide asociada a niveles elevados de inmunoglobulina A: características clínicas y biológicas Jorgensen, C. Anaya, Juan-Manuel Cognot, C. Sany, J. Serum immunoglobulins Rheumatoid arthritis Polyclonal hyperimmunoglob We measured the serum immunoglobulins in 191 patients with rheumatoid arthritis (RA) over an 8-month period, looking for a relationship between high IgA levels, disease activity, and clinical and biological features. Twenty-nine patients with a polyclonal hyperimmunoglobulin A (IgA) (15.2%) above 5 g/l constituted group A. A control group of 29 randomized RA patients with normal IgA levels was studied over the same period (group B). The mean serum IgA concentration was significantly elevated in group A: 6.6 +/- 1.8 g/l versus 2.8 +/- 0.9 g/l in group B (p < 0.01). In group A, microscopic haematuria occurred in 20.7% of the cases, as against 3.4% from group B (p < 0.05). Furthermore, the incidence of unilateral sacroiliitis and of arthritis of the distal interphalangeal joints was significantly increased in group A (41.4% and 34.5%, respectively) against 6.9% and 3.4% in group B (p < 0.01) and this correlated with a high IgA serum level (p < 0.01). On the other hand, neither disease activity nor the biological parameters of inflammation were influenced by the level of IgA. Patients with RA associated with high levels of IgA are characterized by a significant increase in the incidence of distal interphalangeal arthritis, unilateral sacroiliitis and microscopic haematuria. These clinical and biological features could define a distinct subgroup of patients with RA. 1992 2020-08-19T14:40:29Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0392-856X EISSN: 1593-098X https://repository.urosario.edu.co/handle/10336/26903 eng info:eu-repo/semantics/closedAccess application/pdf Europe PMC Clinical and Experimental Rheumatology
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Serum immunoglobulins
Rheumatoid arthritis
Polyclonal hyperimmunoglob
spellingShingle Serum immunoglobulins
Rheumatoid arthritis
Polyclonal hyperimmunoglob
Jorgensen, C.
Anaya, Juan-Manuel
Cognot, C.
Sany, J.
Rheumatoid arthritis associated with high levels of immunoglobulin A: Clinical and biological characteristics
description We measured the serum immunoglobulins in 191 patients with rheumatoid arthritis (RA) over an 8-month period, looking for a relationship between high IgA levels, disease activity, and clinical and biological features. Twenty-nine patients with a polyclonal hyperimmunoglobulin A (IgA) (15.2%) above 5 g/l constituted group A. A control group of 29 randomized RA patients with normal IgA levels was studied over the same period (group B). The mean serum IgA concentration was significantly elevated in group A: 6.6 +/- 1.8 g/l versus 2.8 +/- 0.9 g/l in group B (p < 0.01). In group A, microscopic haematuria occurred in 20.7% of the cases, as against 3.4% from group B (p < 0.05). Furthermore, the incidence of unilateral sacroiliitis and of arthritis of the distal interphalangeal joints was significantly increased in group A (41.4% and 34.5%, respectively) against 6.9% and 3.4% in group B (p < 0.01) and this correlated with a high IgA serum level (p < 0.01). On the other hand, neither disease activity nor the biological parameters of inflammation were influenced by the level of IgA. Patients with RA associated with high levels of IgA are characterized by a significant increase in the incidence of distal interphalangeal arthritis, unilateral sacroiliitis and microscopic haematuria. These clinical and biological features could define a distinct subgroup of patients with RA.
format Artículo (Article)
author Jorgensen, C.
Anaya, Juan-Manuel
Cognot, C.
Sany, J.
author_facet Jorgensen, C.
Anaya, Juan-Manuel
Cognot, C.
Sany, J.
author_sort Jorgensen, C.
title Rheumatoid arthritis associated with high levels of immunoglobulin A: Clinical and biological characteristics
title_short Rheumatoid arthritis associated with high levels of immunoglobulin A: Clinical and biological characteristics
title_full Rheumatoid arthritis associated with high levels of immunoglobulin A: Clinical and biological characteristics
title_fullStr Rheumatoid arthritis associated with high levels of immunoglobulin A: Clinical and biological characteristics
title_full_unstemmed Rheumatoid arthritis associated with high levels of immunoglobulin A: Clinical and biological characteristics
title_sort rheumatoid arthritis associated with high levels of immunoglobulin a: clinical and biological characteristics
publisher Europe PMC
publishDate 1992
url https://repository.urosario.edu.co/handle/10336/26903
_version_ 1712098587861581824
score 11,896154