Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.

Background: Strong evidence has demonstrated that exercise training reduces breast cancer risk by 10-25%, and several biological mechanisms have been proposed to explain the positive modulation of inflammatory mediators associated with the tumor microenvironment. This study aims to determine the eff...

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Autores Principales: Meneses-Echavez, Jose F, Ramirez-Velez, Robinson, Correa Bautista, Jorge Enrique
Formato: Objeto de conferencia (Conference Object)
Lenguaje:Inglés (English)
Publicado: American Society of Clinical Oncology 2015
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/26450
https://doi.org/10.1200/jco.2015.33.15_suppl.e12581
id ir-10336-26450
recordtype dspace
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Breast cancer
Oncology and Carcinogenesis
Exercise training
spellingShingle Breast cancer
Oncology and Carcinogenesis
Exercise training
Meneses-Echavez, Jose F
Ramirez-Velez, Robinson
Correa Bautista, Jorge Enrique
Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.
description Background: Strong evidence has demonstrated that exercise training reduces breast cancer risk by 10-25%, and several biological mechanisms have been proposed to explain the positive modulation of inflammatory mediators associated with the tumor microenvironment. This study aims to determine the effects of exercise training on markers of low-grade inflammation in breast cancer survivors. Methods: A systematic literature review of randomized controlled trials (RCTs) evaluating the changes in inflammatory mediators in breast cancer survivors after exercise training was performed. The PubMed, Embase, Scopus and CENTRAL databases and other gray literature resources were searched without language restrictions from January 1990 to March 2014. Two investigators screened and identified the studies that met the inclusion criteria. An inverse of variance model of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity (I2< 50%). Publication bias was evaluated using Egger’s test (p < 0.05). Results: Nine high-quality RCTs (n = 349) were ultimately included. Exercise training improved the serum concentrations of IL-6 (mean difference (MD) = -0.37, 95%CI -0.61 to -0.12), IL-2 (MD = 1.03, 95%CI 0.39 to 1.66), IL-8 (MD = -0.49, 95%CI -0.89 to-0.08) and TNF-? (MD = -0.48, 95%CI -0.96 to -0.003, p = 0.04). Conversely, no significant differences were found in the serum concentrations of C-reactive protein (CRP) or IL-10. There was no evidence of publication bias (p= 0.06). Conclusions: Exercise training positively modulates low-grade inflammation in women with breast cancer, impacting carcinogenic mechanisms and the tumor microenvironment. Additional RCTs are required to further elucidate the anti-inflammatory effects of exercise on breast cancer survivors.
format Objeto de conferencia (Conference Object)
author Meneses-Echavez, Jose F
Ramirez-Velez, Robinson
Correa Bautista, Jorge Enrique
author_facet Meneses-Echavez, Jose F
Ramirez-Velez, Robinson
Correa Bautista, Jorge Enrique
author_sort Meneses-Echavez, Jose F
title Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.
title_short Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.
title_full Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.
title_fullStr Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.
title_full_unstemmed Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.
title_sort low-grade inflammation and exercise training in women with breast cancer: a meta-analysis with meta-regression.
publisher American Society of Clinical Oncology
publishDate 2015
url https://repository.urosario.edu.co/handle/10336/26450
https://doi.org/10.1200/jco.2015.33.15_suppl.e12581
_version_ 1675439944005320704
spelling ir-10336-264502020-08-06T16:24:14Z Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression. Inflamación de bajo grado y entrenamiento físico en mujeres con cáncer de mama: un metanálisis con metarregresión. Meneses-Echavez, Jose F Ramirez-Velez, Robinson Correa Bautista, Jorge Enrique Breast cancer Oncology and Carcinogenesis Exercise training Background: Strong evidence has demonstrated that exercise training reduces breast cancer risk by 10-25%, and several biological mechanisms have been proposed to explain the positive modulation of inflammatory mediators associated with the tumor microenvironment. This study aims to determine the effects of exercise training on markers of low-grade inflammation in breast cancer survivors. Methods: A systematic literature review of randomized controlled trials (RCTs) evaluating the changes in inflammatory mediators in breast cancer survivors after exercise training was performed. The PubMed, Embase, Scopus and CENTRAL databases and other gray literature resources were searched without language restrictions from January 1990 to March 2014. Two investigators screened and identified the studies that met the inclusion criteria. An inverse of variance model of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity (I2< 50%). Publication bias was evaluated using Egger’s test (p < 0.05). Results: Nine high-quality RCTs (n = 349) were ultimately included. Exercise training improved the serum concentrations of IL-6 (mean difference (MD) = -0.37, 95%CI -0.61 to -0.12), IL-2 (MD = 1.03, 95%CI 0.39 to 1.66), IL-8 (MD = -0.49, 95%CI -0.89 to-0.08) and TNF-? (MD = -0.48, 95%CI -0.96 to -0.003, p = 0.04). Conversely, no significant differences were found in the serum concentrations of C-reactive protein (CRP) or IL-10. There was no evidence of publication bias (p= 0.06). Conclusions: Exercise training positively modulates low-grade inflammation in women with breast cancer, impacting carcinogenic mechanisms and the tumor microenvironment. Additional RCTs are required to further elucidate the anti-inflammatory effects of exercise on breast cancer survivors. Background: Strong evidence has demonstrated that exercise training reduces breast cancer risk by 10-25%, and several biological mechanisms have been proposed to explain the positive modulation of inflammatory mediators associated with the tumor microenvironment. This study aims to determine the effects of exercise training on markers of low-grade inflammation in breast cancer survivors. Methods: A systematic literature review of randomized controlled trials (RCTs) evaluating the changes in inflammatory mediators in breast cancer survivors after exercise training was performed. The PubMed, Embase, Scopus and CENTRAL databases and other gray literature resources were searched without language restrictions from January 1990 to March 2014. Two investigators screened and identified the studies that met the inclusion criteria. An inverse of variance model of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity (I2< 50%). Publication bias was evaluated using Egger’s test (p < 0.05). Results: Nine high-quality RCTs (n = 349) were ultimately included. Exercise training improved the serum concentrations of IL-6 (mean difference (MD) = -0.37, 95%CI -0.61 to -0.12), IL-2 (MD = 1.03, 95%CI 0.39 to 1.66), IL-8 (MD = -0.49, 95%CI -0.89 to-0.08) and TNF-? (MD = -0.48, 95%CI -0.96 to -0.003, p = 0.04). Conversely, no significant differences were found in the serum concentrations of C-reactive protein (CRP) or IL-10. There was no evidence of publication bias (p= 0.06). Conclusions: Exercise training positively modulates low-grade inflammation in women with breast cancer, impacting carcinogenic mechanisms and the tumor microenvironment. Additional RCTs are required to further elucidate the anti-inflammatory effects of exercise on breast cancer survivors. 2015-05-20 2020-08-06T16:24:05Z info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion ISSN: 0732-183X EISSN: 1527-7755 https://repository.urosario.edu.co/handle/10336/26450 https://doi.org/10.1200/jco.2015.33.15_suppl.e12581 eng info:eu-repo/semantics/closedAccess application/pdf American Society of Clinical Oncology Journal of Clinical Oncology
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