Vista Equipo: Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis

Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis

Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD). Since atherosclerosis development is a gradual process of damage inside the artery wall, and the phenotype–genotype correlation of complex diseases may vary depending on ethnicity, we sought to inve...

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Autores Principales:	Rojas-Villarraga, Adriana, Ortega-Hernandez, Oscar-Danilo, Gomez, Luis F., Pardo, Aryce L., Arango-Ferreira, Camila, Hincapie, Maria-Eugenia, Betancur, Juan F., Pineda-Tamayo, Ricardo, Diaz, Francisco J., Anaya, Juan-Manuel, López Guzmán, Silvia
Formato:	Artículo (Article)
Lenguaje:	Inglés (English)
Publicado:	Elsevier 2008
Materias:	Adult Arthritis Rheumatoid Carotid Artery Diseases Colombia Endothelium Vascular Female Humans Male Middle Aged Rheumatoid Factor Risk Assessment Risk Factors Severity of Illness Index Tunica Intima Tunica Media Ultrasonography
Acceso en línea:	https://repository.urosario.edu.co/handle/10336/26125 https://doi.org/10.1016/j.semarthrit.2008.01.019

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recordtype	dspace
spelling	ir-10336-261252021-08-14T04:01:25Z Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis Factores de riesgo asociados con diferentes etapas de la aterosclerosis en pacientes colombianos con artritis reumatoide Rojas-Villarraga, Adriana Ortega-Hernandez, Oscar-Danilo Gomez, Luis F. Pardo, Aryce L. Arango-Ferreira, Camila Hincapie, Maria-Eugenia Betancur, Juan F. Pineda-Tamayo, Ricardo Diaz, Francisco J. Anaya, Juan-Manuel López Guzmán, Silvia Adult Arthritis Rheumatoid Carotid Artery Diseases Colombia Endothelium Vascular Female Humans Male Middle Aged Rheumatoid Factor Risk Assessment Risk Factors Severity of Illness Index Tunica Intima Tunica Media Ultrasonography Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD). Since atherosclerosis development is a gradual process of damage inside the artery wall, and the phenotype–genotype correlation of complex diseases may vary depending on ethnicity, we sought to investigate the influence of clinical features, routine inflammatory markers, and the genetic component of RA on different stages of atherosclerosis in northwestern Colombian patients with RA. Methods A group of 140 patients with RA were enrolled in this study. All patients underwent a noninvasive evaluation of endothelial function by flow-mediated vasodilation (FMV) and an assessment of carotid intima-media thickness (IMT) by high-resolution B-mode ultrasonography. The patients were classified into 3 categories: endothelial dysfunction (FMV <5%), increased IMT (0.91-1.29 mm), and plaque (IMT >1.30 mm). The risk of being in each category was assessed by investigating traditional and nontraditional cardiovascular risk factors. For each stage of atherosclerosis development, we searched for nontraditional risk factors that were significantly associated with the stage after adjusting for traditional risk factors and current age. 2008-10-01 2020-08-06T16:20:44Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0049-0172 EISSN: 1532-866X https://repository.urosario.edu.co/handle/10336/26125 https://doi.org/10.1016/j.semarthrit.2008.01.019 eng info:eu-repo/semantics/openAccess application/pdf Elsevier Seminars in Arthritis and Rheumatism
institution	EdocUR - Universidad del Rosario
collection	DSpace
language	Inglés (English)
topic	Adult Arthritis Rheumatoid Carotid Artery Diseases Colombia Endothelium Vascular Female Humans Male Middle Aged Rheumatoid Factor Risk Assessment Risk Factors Severity of Illness Index Tunica Intima Tunica Media Ultrasonography
spellingShingle	Adult Arthritis Rheumatoid Carotid Artery Diseases Colombia Endothelium Vascular Female Humans Male Middle Aged Rheumatoid Factor Risk Assessment Risk Factors Severity of Illness Index Tunica Intima Tunica Media Ultrasonography Rojas-Villarraga, Adriana Ortega-Hernandez, Oscar-Danilo Gomez, Luis F. Pardo, Aryce L. Arango-Ferreira, Camila Hincapie, Maria-Eugenia Betancur, Juan F. Pineda-Tamayo, Ricardo Diaz, Francisco J. Anaya, Juan-Manuel López Guzmán, Silvia Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis
description	Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD). Since atherosclerosis development is a gradual process of damage inside the artery wall, and the phenotype–genotype correlation of complex diseases may vary depending on ethnicity, we sought to investigate the influence of clinical features, routine inflammatory markers, and the genetic component of RA on different stages of atherosclerosis in northwestern Colombian patients with RA. Methods A group of 140 patients with RA were enrolled in this study. All patients underwent a noninvasive evaluation of endothelial function by flow-mediated vasodilation (FMV) and an assessment of carotid intima-media thickness (IMT) by high-resolution B-mode ultrasonography. The patients were classified into 3 categories: endothelial dysfunction (FMV <5%), increased IMT (0.91-1.29 mm), and plaque (IMT >1.30 mm). The risk of being in each category was assessed by investigating traditional and nontraditional cardiovascular risk factors. For each stage of atherosclerosis development, we searched for nontraditional risk factors that were significantly associated with the stage after adjusting for traditional risk factors and current age.
format	Artículo (Article)
author	Rojas-Villarraga, Adriana Ortega-Hernandez, Oscar-Danilo Gomez, Luis F. Pardo, Aryce L. Arango-Ferreira, Camila Hincapie, Maria-Eugenia Betancur, Juan F. Pineda-Tamayo, Ricardo Diaz, Francisco J. Anaya, Juan-Manuel López Guzmán, Silvia
author_facet	Rojas-Villarraga, Adriana Ortega-Hernandez, Oscar-Danilo Gomez, Luis F. Pardo, Aryce L. Arango-Ferreira, Camila Hincapie, Maria-Eugenia Betancur, Juan F. Pineda-Tamayo, Ricardo Diaz, Francisco J. Anaya, Juan-Manuel López Guzmán, Silvia
author_sort	Rojas-Villarraga, Adriana
title	Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis
title_short	Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis
title_full	Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis
title_fullStr	Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis
title_full_unstemmed	Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis
title_sort	risk factors associated with different stages of atherosclerosis in colombian patients with rheumatoid arthritis
publisher	Elsevier
publishDate	2008
url	https://repository.urosario.edu.co/handle/10336/26125 https://doi.org/10.1016/j.semarthrit.2008.01.019
_version_	1712098586965049344
score	12,131701

Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis

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