Phi (?) and psi (?) angles involved in malarial peptide bonds determine sterile protective immunity

"Modified HABP (mHABP) regions interacting with HLA-DR?1 molecules have a more restricted conformation and/or sequence than other mHABPs which do not fit perfectly into their peptide binding regions (PBR) and do not induce an acceptable immune response due to the critical role of their ? and ?...

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Autores Principales: Patarroyo, Manuel E., Moreno-Vranich, Armando, Bermúdez, Adriana
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/25980
https://doi.org/10.1016/j.bbrc.2012.10.089
id ir-10336-25980
recordtype dspace
spelling ir-10336-259802020-08-06T16:22:08Z Phi (?) and psi (?) angles involved in malarial peptide bonds determine sterile protective immunity Los ángulos Phi (?) y psi (?) involucrados en los enlaces peptídicos de la malaria determinan la inmunidad protectora estéril Patarroyo, Manuel E. Moreno-Vranich, Armando Bermúdez, Adriana Phi and psi angles Antimalarial vaccine Left-handed polyproline type II helix HLA-DR?1 molecules "Modified HABP (mHABP) regions interacting with HLA-DR?1 molecules have a more restricted conformation and/or sequence than other mHABPs which do not fit perfectly into their peptide binding regions (PBR) and do not induce an acceptable immune response due to the critical role of their ? and ? torsion angles. These angle’s critical role was determined in such highly immunogenic, protection-inducing response against experimental malaria using the conformers (mHABPs) obtained by 1H-NMR and superimposed into HLA-DR?1?-like Aotus monkey molecules; their phi (?) and psi (?) angles were measured and the H-bond formation between these molecules was evaluated. The aforementioned mHABP propensity to assume a regular conformation similar to a left-handed polyproline type II helix (PPIIL) led to suggesting that favouring these conformations according to their amino acid sequence would lead to high antibody titre production and sterile protective immunity induction against malaria, thereby adding new principles or rules for vaccine development, malaria being one of them." 2012-12-07 2020-08-06T16:20:22Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ISSN: 0006-291X EISSN: 1090-2104 https://repository.urosario.edu.co/handle/10336/25980 https://doi.org/10.1016/j.bbrc.2012.10.089 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Biochemical and Biophysical Research Communications
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Phi and psi angles
Antimalarial vaccine
Left-handed polyproline type II helix
HLA-DR?1 molecules
spellingShingle Phi and psi angles
Antimalarial vaccine
Left-handed polyproline type II helix
HLA-DR?1 molecules
Patarroyo, Manuel E.
Moreno-Vranich, Armando
Bermúdez, Adriana
Phi (?) and psi (?) angles involved in malarial peptide bonds determine sterile protective immunity
description "Modified HABP (mHABP) regions interacting with HLA-DR?1 molecules have a more restricted conformation and/or sequence than other mHABPs which do not fit perfectly into their peptide binding regions (PBR) and do not induce an acceptable immune response due to the critical role of their ? and ? torsion angles. These angle’s critical role was determined in such highly immunogenic, protection-inducing response against experimental malaria using the conformers (mHABPs) obtained by 1H-NMR and superimposed into HLA-DR?1?-like Aotus monkey molecules; their phi (?) and psi (?) angles were measured and the H-bond formation between these molecules was evaluated. The aforementioned mHABP propensity to assume a regular conformation similar to a left-handed polyproline type II helix (PPIIL) led to suggesting that favouring these conformations according to their amino acid sequence would lead to high antibody titre production and sterile protective immunity induction against malaria, thereby adding new principles or rules for vaccine development, malaria being one of them."
format Artículo (Article)
author Patarroyo, Manuel E.
Moreno-Vranich, Armando
Bermúdez, Adriana
author_facet Patarroyo, Manuel E.
Moreno-Vranich, Armando
Bermúdez, Adriana
author_sort Patarroyo, Manuel E.
title Phi (?) and psi (?) angles involved in malarial peptide bonds determine sterile protective immunity
title_short Phi (?) and psi (?) angles involved in malarial peptide bonds determine sterile protective immunity
title_full Phi (?) and psi (?) angles involved in malarial peptide bonds determine sterile protective immunity
title_fullStr Phi (?) and psi (?) angles involved in malarial peptide bonds determine sterile protective immunity
title_full_unstemmed Phi (?) and psi (?) angles involved in malarial peptide bonds determine sterile protective immunity
title_sort phi (?) and psi (?) angles involved in malarial peptide bonds determine sterile protective immunity
publisher Elsevier
publishDate 2012
url https://repository.urosario.edu.co/handle/10336/25980
https://doi.org/10.1016/j.bbrc.2012.10.089
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score 11,366519