Fitting modified HRP-I peptide analogue 3D structure into HLA-DR molecules induces protection against Plasmodium falciparum malaria

Conserved, high-activity, red blood cell binding malaria peptide 6786, from the HRP-I protein, having a random 3D structure as determined by 1H-NMR, was non-immunogenic and non-protection inducing when used as an immunogen in Aotus monkeys. Modifications made in its amino acid sequence were thus per...

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Detalles Bibliográficos
Autores Principales: Bermúdez, Adriana, Alba, Patricia, Espejo, Fabiola, Vargas, Luis Eduardo, Parra, Carlos, Rodríguez, Raúl, Reyes, Claudia, Patarroyo, Manuel Elkin
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Elsevier 2005
Materias:
NMR
Acceso en línea:https://repository.urosario.edu.co/handle/10336/25938
https://doi.org/10.1016/j.biocel.2004.07.012