Autoimmune Thyroid Disease in Rheumatoid Arthritis: A Global Perspective

Objective. To determine the prevalence and impact of autoimmune thyroid disease (AITD) in patients with rheumatoid arthritis (RA). Methods. Eight-hundred patients were included. The association between AITD and RA was analyzed was analyzed by bivariate and multivariate analysis. In addition, a liter...

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Autores Principales: Roldán, Jorge Cárdenas, Amaya-Amaya, Jenny, la Hoz, Juan Castellanos-de, Giraldo-Villamil, Juliana, Montoya-Ortiz, Gladys, Cruz-Tapias, Paola, Rojas-Villarraga, Adriana, Mantilla, Rubén D., Anaya, Juan-Manuel
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Arthritis 2012
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Acceso en línea:https://repository.urosario.edu.co/handle/10336/25105
https://doi.org/10.1155/2012/864907
id ir-10336-25105
recordtype dspace
spelling ir-10336-251052021-08-11T22:37:35Z Autoimmune Thyroid Disease in Rheumatoid Arthritis: A Global Perspective Roldán, Jorge Cárdenas Amaya-Amaya, Jenny la Hoz, Juan Castellanos-de Giraldo-Villamil, Juliana Montoya-Ortiz, Gladys Cruz-Tapias, Paola Rojas-Villarraga, Adriana Mantilla, Rubén D. Anaya, Juan-Manuel Medical and Health Sciences Clinical Sciences Immunology Objective. To determine the prevalence and impact of autoimmune thyroid disease (AITD) in patients with rheumatoid arthritis (RA). Methods. Eight-hundred patients were included. The association between AITD and RA was analyzed was analyzed by bivariate and multivariate analysis. In addition, a literature review was done focusing on geographical variations. Results. In our cohort the prevalence of AITD was 9.8% while the presence of antibodies was 37.8% for antithyroperoxidase enzyme (TPOAb) and 20.8% for antithyroglobulin protein (TgAb). The presence of type 2 diabetes, thrombosis, abnormal body mass index, and a high educational level was positively associated with AITD. The literature review disclosed a geographical variation of AITD in RA ranging from 0.5% to 27%. Autoantibody prevalence ranges from 6% to 31% for TgAb, 5% to 37% for TPOAb, and from 11.4% to 32% for the presence of either of the two. Conclusion. AITD is not uncommon in RA and should be systematically assessed since it is a risk factor for developing diabetes and cardiovascular disease. These results may help to further study the common mechanisms of autoimmune diseases, to improve patients' outcome, and to define public health policies. An international consensus to accurately diagnose AITD is warranted. 2012-11-18 2020-06-11T13:22:22Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 20901984 20901992 https://repository.urosario.edu.co/handle/10336/25105 https://doi.org/10.1155/2012/864907 eng info:eu-repo/semantics/openAccess application/pdf Arthritis instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Medical and Health Sciences
Clinical Sciences
Immunology
spellingShingle Medical and Health Sciences
Clinical Sciences
Immunology
Roldán, Jorge Cárdenas
Amaya-Amaya, Jenny
la Hoz, Juan Castellanos-de
Giraldo-Villamil, Juliana
Montoya-Ortiz, Gladys
Cruz-Tapias, Paola
Rojas-Villarraga, Adriana
Mantilla, Rubén D.
Anaya, Juan-Manuel
Autoimmune Thyroid Disease in Rheumatoid Arthritis: A Global Perspective
description Objective. To determine the prevalence and impact of autoimmune thyroid disease (AITD) in patients with rheumatoid arthritis (RA). Methods. Eight-hundred patients were included. The association between AITD and RA was analyzed was analyzed by bivariate and multivariate analysis. In addition, a literature review was done focusing on geographical variations. Results. In our cohort the prevalence of AITD was 9.8% while the presence of antibodies was 37.8% for antithyroperoxidase enzyme (TPOAb) and 20.8% for antithyroglobulin protein (TgAb). The presence of type 2 diabetes, thrombosis, abnormal body mass index, and a high educational level was positively associated with AITD. The literature review disclosed a geographical variation of AITD in RA ranging from 0.5% to 27%. Autoantibody prevalence ranges from 6% to 31% for TgAb, 5% to 37% for TPOAb, and from 11.4% to 32% for the presence of either of the two. Conclusion. AITD is not uncommon in RA and should be systematically assessed since it is a risk factor for developing diabetes and cardiovascular disease. These results may help to further study the common mechanisms of autoimmune diseases, to improve patients' outcome, and to define public health policies. An international consensus to accurately diagnose AITD is warranted.
format Artículo (Article)
author Roldán, Jorge Cárdenas
Amaya-Amaya, Jenny
la Hoz, Juan Castellanos-de
Giraldo-Villamil, Juliana
Montoya-Ortiz, Gladys
Cruz-Tapias, Paola
Rojas-Villarraga, Adriana
Mantilla, Rubén D.
Anaya, Juan-Manuel
author_facet Roldán, Jorge Cárdenas
Amaya-Amaya, Jenny
la Hoz, Juan Castellanos-de
Giraldo-Villamil, Juliana
Montoya-Ortiz, Gladys
Cruz-Tapias, Paola
Rojas-Villarraga, Adriana
Mantilla, Rubén D.
Anaya, Juan-Manuel
author_sort Roldán, Jorge Cárdenas
title Autoimmune Thyroid Disease in Rheumatoid Arthritis: A Global Perspective
title_short Autoimmune Thyroid Disease in Rheumatoid Arthritis: A Global Perspective
title_full Autoimmune Thyroid Disease in Rheumatoid Arthritis: A Global Perspective
title_fullStr Autoimmune Thyroid Disease in Rheumatoid Arthritis: A Global Perspective
title_full_unstemmed Autoimmune Thyroid Disease in Rheumatoid Arthritis: A Global Perspective
title_sort autoimmune thyroid disease in rheumatoid arthritis: a global perspective
publisher Arthritis
publishDate 2012
url https://repository.urosario.edu.co/handle/10336/25105
https://doi.org/10.1155/2012/864907
_version_ 1712098495706431488
score 11,828437