Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia
Acute leukemia is the most common type of cancer in pediatric patients. This type of cancer accounts for a third of all childhood cancer cases. More than half of pediatric acute leukemia patients show signs and symptoms such as hepatomegaly, splenomegaly, pallor, fever and bruising at the time of di...
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| Formato: | Artículo (Article) |
| Lenguaje: | Inglés (English) |
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Pediatric Reports
2020
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| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/24978 https://doi.org/10.4081/pr.2020.8382 |
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ir-10336-249782021-01-21T08:12:46Z Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia Prada Rico, Mayerly Rodríguez-Cuellar, Carmen Inés Arteaga Aya, Lucy Natalia Nuñez Chates, Claudia Lorena Garces Sterling, Sandra Patricia Pierotty, Mathieu González Chaparro, Luz Esthella Gastelbondo Amaya, Ricardo Cardiorespiratory Medicine and Haematology Medical and Health Sciences Oncology and Carcinogenesis Acute leukemia is the most common type of cancer in pediatric patients. This type of cancer accounts for a third of all childhood cancer cases. More than half of pediatric acute leukemia patients show signs and symptoms such as hepatomegaly, splenomegaly, pallor, fever and bruising at the time of diagnosis. In early stages of acute lymphoblastic leukemia (ALL), nephromegaly and other renal manifestations such as high blood pressure (HBP) and renal failure are uncommon, although renal infiltration and nephromegaly are common in advanced-stage pediatric patients. This is a retrospective case review with a critical appraisal of the existing evidence from the literature. We present a clinical case of a child with HBP associated with bilateral nephromegaly which resolved after chemotherapy treatment. This patient presented with HBP that required pharmacological treatment, likely owing to nephromegaly. All HBP secondary causes were rejected. Nephromegaly was resolved after chemotherapy treatment, and antihypertensive medication was discontinued. Nephromegaly and HBP are rare manifestations of ALL debut in pediatrics. The present case report illustrates this unusual combination and Suggests clinicians to consider malignancy as its causal factor, especially if the symptoms are accompanied by other suggestive extrarenal manifestations. 2020-04-08 2020-06-11T13:21:59Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2036749X 20367503 https://repository.urosario.edu.co/handle/10336/24978 https://doi.org/10.4081/pr.2020.8382 eng info:eu-repo/semantics/openAccess application/pdf Pediatric Reports instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR |
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EdocUR - Universidad del Rosario |
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DSpace |
| language |
Inglés (English) |
| topic |
Cardiorespiratory Medicine and Haematology Medical and Health Sciences Oncology and Carcinogenesis |
| spellingShingle |
Cardiorespiratory Medicine and Haematology Medical and Health Sciences Oncology and Carcinogenesis Prada Rico, Mayerly Rodríguez-Cuellar, Carmen Inés Arteaga Aya, Lucy Natalia Nuñez Chates, Claudia Lorena Garces Sterling, Sandra Patricia Pierotty, Mathieu González Chaparro, Luz Esthella Gastelbondo Amaya, Ricardo Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia |
| description |
Acute leukemia is the most common type of cancer in pediatric patients. This type of cancer accounts for a third of all childhood cancer cases. More than half of pediatric acute leukemia patients show signs and symptoms such as hepatomegaly, splenomegaly, pallor, fever and bruising at the time of diagnosis. In early stages of acute lymphoblastic leukemia (ALL), nephromegaly and other renal manifestations such as high blood pressure (HBP) and renal failure are uncommon, although renal infiltration and nephromegaly are common in advanced-stage pediatric patients. This is a retrospective case review with a critical appraisal of the existing evidence from the literature. We present a clinical case of a child with HBP associated with bilateral nephromegaly which resolved after chemotherapy treatment. This patient presented with HBP that required pharmacological treatment, likely owing to nephromegaly. All HBP secondary causes were rejected. Nephromegaly was resolved after chemotherapy treatment, and antihypertensive medication was discontinued. Nephromegaly and HBP are rare manifestations of ALL debut in pediatrics. The present case report illustrates this unusual combination and Suggests clinicians to consider malignancy as its causal factor, especially if the symptoms are accompanied by other suggestive extrarenal manifestations. |
| format |
Artículo (Article) |
| author |
Prada Rico, Mayerly Rodríguez-Cuellar, Carmen Inés Arteaga Aya, Lucy Natalia Nuñez Chates, Claudia Lorena Garces Sterling, Sandra Patricia Pierotty, Mathieu González Chaparro, Luz Esthella Gastelbondo Amaya, Ricardo |
| author_facet |
Prada Rico, Mayerly Rodríguez-Cuellar, Carmen Inés Arteaga Aya, Lucy Natalia Nuñez Chates, Claudia Lorena Garces Sterling, Sandra Patricia Pierotty, Mathieu González Chaparro, Luz Esthella Gastelbondo Amaya, Ricardo |
| author_sort |
Prada Rico, Mayerly |
| title |
Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia |
| title_short |
Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia |
| title_full |
Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia |
| title_fullStr |
Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia |
| title_full_unstemmed |
Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia |
| title_sort |
renal involvement at diagnosis of pediatric acute lymphoblastic leukemia |
| publisher |
Pediatric Reports |
| publishDate |
2020 |
| url |
https://repository.urosario.edu.co/handle/10336/24978 https://doi.org/10.4081/pr.2020.8382 |
| _version_ |
1690577228045221888 |
| score |
12,131701 |