Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia

Acute leukemia is the most common type of cancer in pediatric patients. This type of cancer accounts for a third of all childhood cancer cases. More than half of pediatric acute leukemia patients show signs and symptoms such as hepatomegaly, splenomegaly, pallor, fever and bruising at the time of di...

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Autores Principales: Prada Rico, Mayerly, Rodríguez-Cuellar, Carmen Inés, Arteaga Aya, Lucy Natalia, Nuñez Chates, Claudia Lorena, Garces Sterling, Sandra Patricia, Pierotty, Mathieu, González Chaparro, Luz Esthella, Gastelbondo Amaya, Ricardo
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Pediatric Reports 2020
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24978
https://doi.org/10.4081/pr.2020.8382
id ir-10336-24978
recordtype dspace
spelling ir-10336-249782021-01-21T08:12:46Z Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia Prada Rico, Mayerly Rodríguez-Cuellar, Carmen Inés Arteaga Aya, Lucy Natalia Nuñez Chates, Claudia Lorena Garces Sterling, Sandra Patricia Pierotty, Mathieu González Chaparro, Luz Esthella Gastelbondo Amaya, Ricardo Cardiorespiratory Medicine and Haematology Medical and Health Sciences Oncology and Carcinogenesis Acute leukemia is the most common type of cancer in pediatric patients. This type of cancer accounts for a third of all childhood cancer cases. More than half of pediatric acute leukemia patients show signs and symptoms such as hepatomegaly, splenomegaly, pallor, fever and bruising at the time of diagnosis. In early stages of acute lymphoblastic leukemia (ALL), nephromegaly and other renal manifestations such as high blood pressure (HBP) and renal failure are uncommon, although renal infiltration and nephromegaly are common in advanced-stage pediatric patients. This is a retrospective case review with a critical appraisal of the existing evidence from the literature. We present a clinical case of a child with HBP associated with bilateral nephromegaly which resolved after chemotherapy treatment. This patient presented with HBP that required pharmacological treatment, likely owing to nephromegaly. All HBP secondary causes were rejected. Nephromegaly was resolved after chemotherapy treatment, and antihypertensive medication was discontinued. Nephromegaly and HBP are rare manifestations of ALL debut in pediatrics. The present case report illustrates this unusual combination and Suggests clinicians to consider malignancy as its causal factor, especially if the symptoms are accompanied by other suggestive extrarenal manifestations. 2020-04-08 2020-06-11T13:21:59Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2036749X 20367503 https://repository.urosario.edu.co/handle/10336/24978 https://doi.org/10.4081/pr.2020.8382 eng info:eu-repo/semantics/openAccess application/pdf Pediatric Reports instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Cardiorespiratory Medicine and Haematology
Medical and Health Sciences
Oncology and Carcinogenesis
spellingShingle Cardiorespiratory Medicine and Haematology
Medical and Health Sciences
Oncology and Carcinogenesis
Prada Rico, Mayerly
Rodríguez-Cuellar, Carmen Inés
Arteaga Aya, Lucy Natalia
Nuñez Chates, Claudia Lorena
Garces Sterling, Sandra Patricia
Pierotty, Mathieu
González Chaparro, Luz Esthella
Gastelbondo Amaya, Ricardo
Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia
description Acute leukemia is the most common type of cancer in pediatric patients. This type of cancer accounts for a third of all childhood cancer cases. More than half of pediatric acute leukemia patients show signs and symptoms such as hepatomegaly, splenomegaly, pallor, fever and bruising at the time of diagnosis. In early stages of acute lymphoblastic leukemia (ALL), nephromegaly and other renal manifestations such as high blood pressure (HBP) and renal failure are uncommon, although renal infiltration and nephromegaly are common in advanced-stage pediatric patients. This is a retrospective case review with a critical appraisal of the existing evidence from the literature. We present a clinical case of a child with HBP associated with bilateral nephromegaly which resolved after chemotherapy treatment. This patient presented with HBP that required pharmacological treatment, likely owing to nephromegaly. All HBP secondary causes were rejected. Nephromegaly was resolved after chemotherapy treatment, and antihypertensive medication was discontinued. Nephromegaly and HBP are rare manifestations of ALL debut in pediatrics. The present case report illustrates this unusual combination and Suggests clinicians to consider malignancy as its causal factor, especially if the symptoms are accompanied by other suggestive extrarenal manifestations.
format Artículo (Article)
author Prada Rico, Mayerly
Rodríguez-Cuellar, Carmen Inés
Arteaga Aya, Lucy Natalia
Nuñez Chates, Claudia Lorena
Garces Sterling, Sandra Patricia
Pierotty, Mathieu
González Chaparro, Luz Esthella
Gastelbondo Amaya, Ricardo
author_facet Prada Rico, Mayerly
Rodríguez-Cuellar, Carmen Inés
Arteaga Aya, Lucy Natalia
Nuñez Chates, Claudia Lorena
Garces Sterling, Sandra Patricia
Pierotty, Mathieu
González Chaparro, Luz Esthella
Gastelbondo Amaya, Ricardo
author_sort Prada Rico, Mayerly
title Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia
title_short Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia
title_full Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia
title_fullStr Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia
title_full_unstemmed Renal involvement at diagnosis of pediatric acute lymphoblastic leukemia
title_sort renal involvement at diagnosis of pediatric acute lymphoblastic leukemia
publisher Pediatric Reports
publishDate 2020
url https://repository.urosario.edu.co/handle/10336/24978
https://doi.org/10.4081/pr.2020.8382
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