Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy

Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver dise...

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Autores Principales: Suarez, Oscar, Perez, María, Garzon, Martin, Daza, Rodrigo, Hernandez, Geovanny, Salinas, Carolina, Ceballos, Jorge, de Leon, Enrique P, Mugnier, Jacqueline, Beltrán, Oscar, Varón, Adriana
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Case Reports in Hepatology 2018
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24758
https://doi.org/10.1155/2018/7521986
id ir-10336-24758
recordtype dspace
spelling ir-10336-247582021-01-21T08:11:10Z Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy Suarez, Oscar Perez, María Garzon, Martin Daza, Rodrigo Hernandez, Geovanny Salinas, Carolina Ceballos, Jorge de Leon, Enrique P Mugnier, Jacqueline Beltrán, Oscar Varón, Adriana Medical and Health Sciences Clinical Sciences Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver disease. The clinical presentation is unspecific, with symptoms ranging from abdominal pain, malaise, and weight loss to atypical manifestation which include hyperammonemic encephalopathy. We present the case of a 33-year-old woman with no prior medical history who presented with a coma and a diagnosis of inoperable fibrolamellar hepatocarcinoma requiring a cadaver donor transplant. While she was on the waiting list, she received hemofiltration and ammonium benzoate treatment, with progressive improvement in her state of consciousness. 2018-12-09 2020-06-11T13:21:10Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://repository.urosario.edu.co/handle/10336/24758 https://doi.org/10.1155/2018/7521986 eng info:eu-repo/semantics/openAccess application/pdf Case Reports in Hepatology instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Medical and Health Sciences
Clinical Sciences
spellingShingle Medical and Health Sciences
Clinical Sciences
Suarez, Oscar
Perez, María
Garzon, Martin
Daza, Rodrigo
Hernandez, Geovanny
Salinas, Carolina
Ceballos, Jorge
de Leon, Enrique P
Mugnier, Jacqueline
Beltrán, Oscar
Varón, Adriana
Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy
description Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver disease. The clinical presentation is unspecific, with symptoms ranging from abdominal pain, malaise, and weight loss to atypical manifestation which include hyperammonemic encephalopathy. We present the case of a 33-year-old woman with no prior medical history who presented with a coma and a diagnosis of inoperable fibrolamellar hepatocarcinoma requiring a cadaver donor transplant. While she was on the waiting list, she received hemofiltration and ammonium benzoate treatment, with progressive improvement in her state of consciousness.
format Artículo (Article)
author Suarez, Oscar
Perez, María
Garzon, Martin
Daza, Rodrigo
Hernandez, Geovanny
Salinas, Carolina
Ceballos, Jorge
de Leon, Enrique P
Mugnier, Jacqueline
Beltrán, Oscar
Varón, Adriana
author_facet Suarez, Oscar
Perez, María
Garzon, Martin
Daza, Rodrigo
Hernandez, Geovanny
Salinas, Carolina
Ceballos, Jorge
de Leon, Enrique P
Mugnier, Jacqueline
Beltrán, Oscar
Varón, Adriana
author_sort Suarez, Oscar
title Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy
title_short Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy
title_full Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy
title_fullStr Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy
title_full_unstemmed Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy
title_sort fibrolamellar hepatocellular carcinoma and noncirrhotic hyperammonemic encephalopathy
publisher Case Reports in Hepatology
publishDate 2018
url https://repository.urosario.edu.co/handle/10336/24758
https://doi.org/10.1155/2018/7521986
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score 11,388624