Elevated levels of D?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia

"OBJECTIVE: To establish the association between increased levels of D-dimer and severity of pre-eclampsia.METHODS: A nested, prospective cohort, analytical case-control study was conducted among women with pre-eclampsia between March 2017 and March 2018. Inclusion criteria were age over 18 yea...

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Autores Principales: Rodríguez?Peña, Yolima, Ibáñez?Pinilla, Milcíades
Formato: Artículo (Article)
Publicado: International Journal of Gynecology & Obstetrics 2020
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Acceso en línea:https://repository.urosario.edu.co/handle/10336/24701
https://doi.org/10.1002/ijgo.13163
id ir-10336-24701
recordtype dspace
spelling ir-10336-247012020-06-11T13:21:03Z Elevated levels of D?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia Rodríguez?Peña, Yolima Ibáñez?Pinilla, Milcíades Medical and Health Sciences Paediatrics and Reproductive Medicine "OBJECTIVE: To establish the association between increased levels of D-dimer and severity of pre-eclampsia.METHODS: A nested, prospective cohort, analytical case-control study was conducted among women with pre-eclampsia between March 2017 and March 2018. Inclusion criteria were age over 18 years, gestational age of more than 20 weeks, a single pregnancy with a living fetus, and a diagnosis of pre-eclampsia. D-dimer was measured by immunoturbidimetry at the time of diagnosis of pre-eclampsia, applying cut-off points adjusted for gestational age. Statistical analysis involved unconditional logistic regression for the association of elevated D-dimer with severe pre-eclampsia adjusted by confusion variables.RESULTS: There were 132 patients with pre-eclampsia, of which 44 were classed as controls and 88 were classed as having severe pre-eclampsia (case group). Cohort characteristics included: age between 18 and 45 years (mean 28.0 ± 6.3 years); presence of gestational hypertension (10.6%), chronic arterial hypertension (9.0%); and gestational diabetes (5.3%). In the case group, levels of D-dimer were significantly higher than in controls (19.3% vs 2.3%, odds ratio [OR] 10.30, 95% confidence interval [CI] 1.32-80.14, P=0.004) as well as significant in the unconditional logistic regression model adjusted for maternal age, parity, gestational age, and comorbidities (OR 10.02, 95% CI 1.28-78.68, P=0.028).CONCLUSION: Elevated levels of D-dimer and severe pre-eclampsia are strongly associated, reinforcing evidence that one of the physiopathologic bases of the condition is the activation of fibrinolysis and the coagulation system." 2020-04-13 2020-06-11T13:21:03Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://repository.urosario.edu.co/handle/10336/24701 https://doi.org/10.1002/ijgo.13163 info:eu-repo/semantics/closedAccess application/pdf International Journal of Gynecology & Obstetrics instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
topic Medical and Health Sciences
Paediatrics and Reproductive Medicine
spellingShingle Medical and Health Sciences
Paediatrics and Reproductive Medicine
Rodríguez?Peña, Yolima
Ibáñez?Pinilla, Milcíades
Elevated levels of D?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia
description "OBJECTIVE: To establish the association between increased levels of D-dimer and severity of pre-eclampsia.METHODS: A nested, prospective cohort, analytical case-control study was conducted among women with pre-eclampsia between March 2017 and March 2018. Inclusion criteria were age over 18 years, gestational age of more than 20 weeks, a single pregnancy with a living fetus, and a diagnosis of pre-eclampsia. D-dimer was measured by immunoturbidimetry at the time of diagnosis of pre-eclampsia, applying cut-off points adjusted for gestational age. Statistical analysis involved unconditional logistic regression for the association of elevated D-dimer with severe pre-eclampsia adjusted by confusion variables.RESULTS: There were 132 patients with pre-eclampsia, of which 44 were classed as controls and 88 were classed as having severe pre-eclampsia (case group). Cohort characteristics included: age between 18 and 45 years (mean 28.0 ± 6.3 years); presence of gestational hypertension (10.6%), chronic arterial hypertension (9.0%); and gestational diabetes (5.3%). In the case group, levels of D-dimer were significantly higher than in controls (19.3% vs 2.3%, odds ratio [OR] 10.30, 95% confidence interval [CI] 1.32-80.14, P=0.004) as well as significant in the unconditional logistic regression model adjusted for maternal age, parity, gestational age, and comorbidities (OR 10.02, 95% CI 1.28-78.68, P=0.028).CONCLUSION: Elevated levels of D-dimer and severe pre-eclampsia are strongly associated, reinforcing evidence that one of the physiopathologic bases of the condition is the activation of fibrinolysis and the coagulation system."
format Artículo (Article)
author Rodríguez?Peña, Yolima
Ibáñez?Pinilla, Milcíades
author_facet Rodríguez?Peña, Yolima
Ibáñez?Pinilla, Milcíades
author_sort Rodríguez?Peña, Yolima
title Elevated levels of D?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia
title_short Elevated levels of D?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia
title_full Elevated levels of D?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia
title_fullStr Elevated levels of D?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia
title_full_unstemmed Elevated levels of D?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia
title_sort elevated levels of d?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia
publisher International Journal of Gynecology & Obstetrics
publishDate 2020
url https://repository.urosario.edu.co/handle/10336/24701
https://doi.org/10.1002/ijgo.13163
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score 11,828437