Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome...

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Autores Principales: Garzón-Ospina, Diego, Forero-Rodríguez, Johanna, Patarroyo, Manuel A.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24298
https://doi.org/10.1016/j.meegid.2015.05.001
id ir-10336-24298
recordtype dspace
spelling ir-10336-242982021-01-21T08:34:25Z Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion Garzón-Ospina, Diego Forero-Rodríguez, Johanna Patarroyo, Manuel A. Allele Article Dna polymorphism Dna sequence Gene mutation Genetic variability Merozoite Microbial gene Multigene family Natural selection Nonhuman Plasmodium vivax Priority journal Signal transduction Biology Genetic polymorphism Genetic selection Genetic variation Genetics Host parasite interaction Metabolism Phylogeny Physiology Plasmodium vivax Plasmodium parasites Plasmodium vivax Protozoal protein Computational biology Genetic variation Host-parasite interactions Phylogeny Plasmodium vivax Polymorphism, genetic Protozoan proteins Selection, genetic Sequence analysis, dna Allele-specific response Anti-malarial vaccine Natural selection signal Plasmodium vivax Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses. © 2015 Elsevier B.V. 2015 2020-05-26T00:11:22Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15671348 https://repository.urosario.edu.co/handle/10336/24298 https://doi.org/10.1016/j.meegid.2015.05.001 eng info:eu-repo/semantics/openAccess application/pdf Elsevier instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Allele
Article
Dna polymorphism
Dna sequence
Gene mutation
Genetic variability
Merozoite
Microbial gene
Multigene family
Natural selection
Nonhuman
Plasmodium vivax
Priority journal
Signal transduction
Biology
Genetic polymorphism
Genetic selection
Genetic variation
Genetics
Host parasite interaction
Metabolism
Phylogeny
Physiology
Plasmodium vivax
Plasmodium parasites
Plasmodium vivax
Protozoal protein
Computational biology
Genetic variation
Host-parasite interactions
Phylogeny
Plasmodium vivax
Polymorphism, genetic
Protozoan proteins
Selection, genetic
Sequence analysis, dna
Allele-specific response
Anti-malarial vaccine
Natural selection signal
Plasmodium vivax
spellingShingle Allele
Article
Dna polymorphism
Dna sequence
Gene mutation
Genetic variability
Merozoite
Microbial gene
Multigene family
Natural selection
Nonhuman
Plasmodium vivax
Priority journal
Signal transduction
Biology
Genetic polymorphism
Genetic selection
Genetic variation
Genetics
Host parasite interaction
Metabolism
Phylogeny
Physiology
Plasmodium vivax
Plasmodium parasites
Plasmodium vivax
Protozoal protein
Computational biology
Genetic variation
Host-parasite interactions
Phylogeny
Plasmodium vivax
Polymorphism, genetic
Protozoan proteins
Selection, genetic
Sequence analysis, dna
Allele-specific response
Anti-malarial vaccine
Natural selection signal
Plasmodium vivax
Garzón-Ospina, Diego
Forero-Rodríguez, Johanna
Patarroyo, Manuel A.
Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion
description Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses. © 2015 Elsevier B.V.
format Artículo (Article)
author Garzón-Ospina, Diego
Forero-Rodríguez, Johanna
Patarroyo, Manuel A.
author_facet Garzón-Ospina, Diego
Forero-Rodríguez, Johanna
Patarroyo, Manuel A.
author_sort Garzón-Ospina, Diego
title Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion
title_short Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion
title_full Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion
title_fullStr Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion
title_full_unstemmed Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion
title_sort inferring natural selection signals in plasmodium vivax-encoded proteins having a potential role in merozoite invasion
publisher Elsevier
publishDate 2015
url https://repository.urosario.edu.co/handle/10336/24298
https://doi.org/10.1016/j.meegid.2015.05.001
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