Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion
Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome...
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Acceso en línea: | https://repository.urosario.edu.co/handle/10336/24298 https://doi.org/10.1016/j.meegid.2015.05.001 |
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ir-10336-242982021-01-21T08:34:25Z Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion Garzón-Ospina, Diego Forero-Rodríguez, Johanna Patarroyo, Manuel A. Allele Article Dna polymorphism Dna sequence Gene mutation Genetic variability Merozoite Microbial gene Multigene family Natural selection Nonhuman Plasmodium vivax Priority journal Signal transduction Biology Genetic polymorphism Genetic selection Genetic variation Genetics Host parasite interaction Metabolism Phylogeny Physiology Plasmodium vivax Plasmodium parasites Plasmodium vivax Protozoal protein Computational biology Genetic variation Host-parasite interactions Phylogeny Plasmodium vivax Polymorphism, genetic Protozoan proteins Selection, genetic Sequence analysis, dna Allele-specific response Anti-malarial vaccine Natural selection signal Plasmodium vivax Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses. © 2015 Elsevier B.V. 2015 2020-05-26T00:11:22Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15671348 https://repository.urosario.edu.co/handle/10336/24298 https://doi.org/10.1016/j.meegid.2015.05.001 eng info:eu-repo/semantics/openAccess application/pdf Elsevier instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR |
institution |
EdocUR - Universidad del Rosario |
collection |
DSpace |
language |
Inglés (English) |
topic |
Allele Article Dna polymorphism Dna sequence Gene mutation Genetic variability Merozoite Microbial gene Multigene family Natural selection Nonhuman Plasmodium vivax Priority journal Signal transduction Biology Genetic polymorphism Genetic selection Genetic variation Genetics Host parasite interaction Metabolism Phylogeny Physiology Plasmodium vivax Plasmodium parasites Plasmodium vivax Protozoal protein Computational biology Genetic variation Host-parasite interactions Phylogeny Plasmodium vivax Polymorphism, genetic Protozoan proteins Selection, genetic Sequence analysis, dna Allele-specific response Anti-malarial vaccine Natural selection signal Plasmodium vivax |
spellingShingle |
Allele Article Dna polymorphism Dna sequence Gene mutation Genetic variability Merozoite Microbial gene Multigene family Natural selection Nonhuman Plasmodium vivax Priority journal Signal transduction Biology Genetic polymorphism Genetic selection Genetic variation Genetics Host parasite interaction Metabolism Phylogeny Physiology Plasmodium vivax Plasmodium parasites Plasmodium vivax Protozoal protein Computational biology Genetic variation Host-parasite interactions Phylogeny Plasmodium vivax Polymorphism, genetic Protozoan proteins Selection, genetic Sequence analysis, dna Allele-specific response Anti-malarial vaccine Natural selection signal Plasmodium vivax Garzón-Ospina, Diego Forero-Rodríguez, Johanna Patarroyo, Manuel A. Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion |
description |
Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses. © 2015 Elsevier B.V. |
format |
Artículo (Article) |
author |
Garzón-Ospina, Diego Forero-Rodríguez, Johanna Patarroyo, Manuel A. |
author_facet |
Garzón-Ospina, Diego Forero-Rodríguez, Johanna Patarroyo, Manuel A. |
author_sort |
Garzón-Ospina, Diego |
title |
Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion |
title_short |
Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion |
title_full |
Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion |
title_fullStr |
Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion |
title_full_unstemmed |
Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion |
title_sort |
inferring natural selection signals in plasmodium vivax-encoded proteins having a potential role in merozoite invasion |
publisher |
Elsevier |
publishDate |
2015 |
url |
https://repository.urosario.edu.co/handle/10336/24298 https://doi.org/10.1016/j.meegid.2015.05.001 |
_version_ |
1690577316890017792 |
score |
12,131701 |