Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates

The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both access...

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Autores Principales: Garzón-Ospina D., Romero-Murillo L., Tobón L.F., Patarroyo M.A.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2011
Materias:
P
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24294
https://doi.org/10.1016/j.meegid.2010.12.002
id ir-10336-24294
recordtype dspace
spelling ir-10336-242942022-05-02T12:37:21Z Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates Garzón-Ospina D. Romero-Murillo L. Tobón L.F. Patarroyo M.A. Membrane protein Merozoite surface protein 10 Merozoite surface protein 7a Merozoite surface protein 7k Unclassified drug Article Colombia Controlled study Genetic conservation Genetic polymorphism Genetic variability Geography Haplotype Nonhuman Nucleotide sequence Plasmodium vivax Priority journal Colombia Genetic variation Genotype Host-parasite interactions Humans Malaria vaccines Membrane proteins Molecular sequence data Plasmodium vivax Polymerase chain reaction Protozoan proteins Plasmodium vivax Genetic polymorphism Merozoite surface protein P Vivax Vaccine candidate genetic vivax protozoan Antigens Malaria Polymorphism The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V. 2011 2020-05-26T00:11:18Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15671348 https://repository.urosario.edu.co/handle/10336/24294 https://doi.org/10.1016/j.meegid.2010.12.002 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Membrane protein
Merozoite surface protein 10
Merozoite surface protein 7a
Merozoite surface protein 7k
Unclassified drug
Article
Colombia
Controlled study
Genetic conservation
Genetic polymorphism
Genetic variability
Geography
Haplotype
Nonhuman
Nucleotide sequence
Plasmodium vivax
Priority journal
Colombia
Genetic variation
Genotype
Host-parasite interactions
Humans
Malaria vaccines
Membrane proteins
Molecular sequence data
Plasmodium vivax
Polymerase chain reaction
Protozoan proteins
Plasmodium vivax
Genetic polymorphism
Merozoite surface protein
P
Vivax
Vaccine candidate
genetic
vivax
protozoan
Antigens
Malaria
Polymorphism
spellingShingle Membrane protein
Merozoite surface protein 10
Merozoite surface protein 7a
Merozoite surface protein 7k
Unclassified drug
Article
Colombia
Controlled study
Genetic conservation
Genetic polymorphism
Genetic variability
Geography
Haplotype
Nonhuman
Nucleotide sequence
Plasmodium vivax
Priority journal
Colombia
Genetic variation
Genotype
Host-parasite interactions
Humans
Malaria vaccines
Membrane proteins
Molecular sequence data
Plasmodium vivax
Polymerase chain reaction
Protozoan proteins
Plasmodium vivax
Genetic polymorphism
Merozoite surface protein
P
Vivax
Vaccine candidate
genetic
vivax
protozoan
Antigens
Malaria
Polymorphism
Garzón-Ospina D.
Romero-Murillo L.
Tobón L.F.
Patarroyo M.A.
Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
description The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V.
format Artículo (Article)
author Garzón-Ospina D.
Romero-Murillo L.
Tobón L.F.
Patarroyo M.A.
author_facet Garzón-Ospina D.
Romero-Murillo L.
Tobón L.F.
Patarroyo M.A.
author_sort Garzón-Ospina D.
title Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
title_short Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
title_full Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
title_fullStr Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
title_full_unstemmed Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
title_sort low genetic polymorphism of merozoite surface proteins 7 and 10 in colombian plasmodium vivax isolates
publishDate 2011
url https://repository.urosario.edu.co/handle/10336/24294
https://doi.org/10.1016/j.meegid.2010.12.002
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score 12,131701