Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both access...
Autores Principales: | , , , |
---|---|
Formato: | Artículo (Article) |
Lenguaje: | Inglés (English) |
Publicado: |
2011
|
Materias: | |
Acceso en línea: | https://repository.urosario.edu.co/handle/10336/24294 https://doi.org/10.1016/j.meegid.2010.12.002 |
id |
ir-10336-24294 |
---|---|
recordtype |
dspace |
spelling |
ir-10336-242942022-05-02T12:37:21Z Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates Garzón-Ospina D. Romero-Murillo L. Tobón L.F. Patarroyo M.A. Membrane protein Merozoite surface protein 10 Merozoite surface protein 7a Merozoite surface protein 7k Unclassified drug Article Colombia Controlled study Genetic conservation Genetic polymorphism Genetic variability Geography Haplotype Nonhuman Nucleotide sequence Plasmodium vivax Priority journal Colombia Genetic variation Genotype Host-parasite interactions Humans Malaria vaccines Membrane proteins Molecular sequence data Plasmodium vivax Polymerase chain reaction Protozoan proteins Plasmodium vivax Genetic polymorphism Merozoite surface protein P Vivax Vaccine candidate genetic vivax protozoan Antigens Malaria Polymorphism The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V. 2011 2020-05-26T00:11:18Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 15671348 https://repository.urosario.edu.co/handle/10336/24294 https://doi.org/10.1016/j.meegid.2010.12.002 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
institution |
EdocUR - Universidad del Rosario |
collection |
DSpace |
language |
Inglés (English) |
topic |
Membrane protein Merozoite surface protein 10 Merozoite surface protein 7a Merozoite surface protein 7k Unclassified drug Article Colombia Controlled study Genetic conservation Genetic polymorphism Genetic variability Geography Haplotype Nonhuman Nucleotide sequence Plasmodium vivax Priority journal Colombia Genetic variation Genotype Host-parasite interactions Humans Malaria vaccines Membrane proteins Molecular sequence data Plasmodium vivax Polymerase chain reaction Protozoan proteins Plasmodium vivax Genetic polymorphism Merozoite surface protein P Vivax Vaccine candidate genetic vivax protozoan Antigens Malaria Polymorphism |
spellingShingle |
Membrane protein Merozoite surface protein 10 Merozoite surface protein 7a Merozoite surface protein 7k Unclassified drug Article Colombia Controlled study Genetic conservation Genetic polymorphism Genetic variability Geography Haplotype Nonhuman Nucleotide sequence Plasmodium vivax Priority journal Colombia Genetic variation Genotype Host-parasite interactions Humans Malaria vaccines Membrane proteins Molecular sequence data Plasmodium vivax Polymerase chain reaction Protozoan proteins Plasmodium vivax Genetic polymorphism Merozoite surface protein P Vivax Vaccine candidate genetic vivax protozoan Antigens Malaria Polymorphism Garzón-Ospina D. Romero-Murillo L. Tobón L.F. Patarroyo M.A. Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates |
description |
The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V. |
format |
Artículo (Article) |
author |
Garzón-Ospina D. Romero-Murillo L. Tobón L.F. Patarroyo M.A. |
author_facet |
Garzón-Ospina D. Romero-Murillo L. Tobón L.F. Patarroyo M.A. |
author_sort |
Garzón-Ospina D. |
title |
Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates |
title_short |
Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates |
title_full |
Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates |
title_fullStr |
Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates |
title_full_unstemmed |
Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates |
title_sort |
low genetic polymorphism of merozoite surface proteins 7 and 10 in colombian plasmodium vivax isolates |
publishDate |
2011 |
url |
https://repository.urosario.edu.co/handle/10336/24294 https://doi.org/10.1016/j.meegid.2010.12.002 |
_version_ |
1740172527602237440 |
score |
12,131701 |