"Narcolepsy, Infections, and Autoimmunity"

"Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin-producing neurons in the lateral hypothalamus. There is evidence suggesting an autoimmune-mediated process may be the cause of the specific loss of orexin-producing neurons....

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Autores Principales: "Arango, María-Teresa, Kivity, Shaye, Agmon-Levin, Nancy, Chapman, Joab, Givaty, Gili, Shoenfeld, Yehuda"
Formato: Capítulo de libro (Book Chapter)
Lenguaje:Inglés (English)
Publicado: Elsevier Inc. 2015
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24291
https://doi.org/10.1016/B978-0-444-63269-2.00064-7
id ir-10336-24291
recordtype dspace
spelling ir-10336-242912020-06-03T22:15:18Z "Narcolepsy, Infections, and Autoimmunity" "Arango, María-Teresa Kivity, Shaye Agmon-Levin, Nancy Chapman, Joab Givaty, Gili Shoenfeld, Yehuda" Autoimmunity H1N1 H1N1 vaccine Narcolepsy Streptococcus spp. "Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin-producing neurons in the lateral hypothalamus. There is evidence suggesting an autoimmune-mediated process may be the cause of the specific loss of orexin-producing neurons. In particular, there is a strong association with HLA DQB1?06:02 and other polymorphisms in immune-related genes. Moreover, onset of narcolepsy has been related with H1N1 and streptococcal infections, as well as with a dramatic increase of cases after the implementation of the ASO3-adjuvant H1N1 vaccine. This chapter shows how the immune system may be involved in the disease since the precise mechanism remains unknown. However, the possible causes and immunological pathways that can lead to an autoimmune destruction of orexin-producing neurons, such as molecular mimicry, bystander activation, and the combination of genetic and environmental factors are discussed. © 2015 Elsevier B.V. All rights reserved." 2015 2020-05-26T00:11:15Z info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion https://repository.urosario.edu.co/handle/10336/24291 https://doi.org/10.1016/B978-0-444-63269-2.00064-7 eng info:eu-repo/semantics/openAccess application/pdf Elsevier Inc. instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Autoimmunity
H1N1
H1N1 vaccine
Narcolepsy
Streptococcus spp.
spellingShingle Autoimmunity
H1N1
H1N1 vaccine
Narcolepsy
Streptococcus spp.
"Arango, María-Teresa
Kivity, Shaye
Agmon-Levin, Nancy
Chapman, Joab
Givaty, Gili
Shoenfeld, Yehuda"
"Narcolepsy, Infections, and Autoimmunity"
description "Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin-producing neurons in the lateral hypothalamus. There is evidence suggesting an autoimmune-mediated process may be the cause of the specific loss of orexin-producing neurons. In particular, there is a strong association with HLA DQB1?06:02 and other polymorphisms in immune-related genes. Moreover, onset of narcolepsy has been related with H1N1 and streptococcal infections, as well as with a dramatic increase of cases after the implementation of the ASO3-adjuvant H1N1 vaccine. This chapter shows how the immune system may be involved in the disease since the precise mechanism remains unknown. However, the possible causes and immunological pathways that can lead to an autoimmune destruction of orexin-producing neurons, such as molecular mimicry, bystander activation, and the combination of genetic and environmental factors are discussed. © 2015 Elsevier B.V. All rights reserved."
format Capítulo de libro (Book Chapter)
author "Arango, María-Teresa
Kivity, Shaye
Agmon-Levin, Nancy
Chapman, Joab
Givaty, Gili
Shoenfeld, Yehuda"
author_facet "Arango, María-Teresa
Kivity, Shaye
Agmon-Levin, Nancy
Chapman, Joab
Givaty, Gili
Shoenfeld, Yehuda"
author_sort "Arango, María-Teresa
title "Narcolepsy, Infections, and Autoimmunity"
title_short "Narcolepsy, Infections, and Autoimmunity"
title_full "Narcolepsy, Infections, and Autoimmunity"
title_fullStr "Narcolepsy, Infections, and Autoimmunity"
title_full_unstemmed "Narcolepsy, Infections, and Autoimmunity"
title_sort "narcolepsy, infections, and autoimmunity"
publisher Elsevier Inc.
publishDate 2015
url https://repository.urosario.edu.co/handle/10336/24291
https://doi.org/10.1016/B978-0-444-63269-2.00064-7
_version_ 1674171869281910784
score 11,374337