HLA-DRB1 the notorious gene in the mosaic of autoimmunity
The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immu...
| Autores Principales: | , , , , , , |
|---|---|
| Formato: | Artículo (Article) |
| Lenguaje: | Inglés (English) |
| Publicado: |
Humana Press Inc.
2017
|
| Materias: | |
| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/24281 https://doi.org/10.1007/s12026-016-8817-7 |
| id |
ir-10336-24281 |
|---|---|
| recordtype |
dspace |
| spelling |
ir-10336-242812022-05-02T12:37:18Z HLA-DRB1 the notorious gene in the mosaic of autoimmunity Arango M.-T. Perricone C. Kivity S. Cipriano E. Ceccarelli F. Valesini G. Shoenfeld Y. Hepatitis B surface antigen Hepatitis B vaccine HLA DRB1 antigen Influenza vaccine Measles vaccine Mumps vaccine Tumor necrosis factor HLA DRB1 antigen Vaccine Ankylosing spondylitis Article Autoimmune disease Autoimmune thyroiditis Autoimmunity Cytomegalovirus infection Epstein Barr virus infection Ethnicity Gene Genetic polymorphism Genetic risk Graves disease Guillain Barre syndrome Hashimoto disease Hepatitis B Hepatitis C HLA DRB1 gene Human Immune response Infection Insulin dependent diabetes mellitus Major histocompatibility complex Multiple sclerosis Myositis Nonhuman Priority journal Psoriatic arthritis Rheumatoid arthritis Sjoegren syndrome Spondylarthritis Systemic lupus erythematosus Vaccination Animal Autoimmunity Genetics Animals Autoimmune Diseases Autoimmunity HLA-DRB1 Chains Humans Vaccines Autoimmunity DRB1 Gene Genetic HLA system Infections Locus Vaccines Genetic Polymorphism The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against pathogens and strongly implicated in the development of autoimmune diseases. Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines. It is possible that the interaction of specific HLA with pathogenic antigens is one of the keys favoring (or protecting) toward the development of an autoimmune disease. In the era of personalized medicine, it would be of great help to build a map of the genomic risk of each individual to evaluate the risk of developing an autoimmune condition. © 2016, Springer Science+Business Media New York. 2017 2020-05-26T00:11:06Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0257277X https://repository.urosario.edu.co/handle/10336/24281 https://doi.org/10.1007/s12026-016-8817-7 eng info:eu-repo/semantics/openAccess application/pdf Humana Press Inc. instname:Universidad del Rosario |
| institution |
EdocUR - Universidad del Rosario |
| collection |
DSpace |
| language |
Inglés (English) |
| topic |
Hepatitis B surface antigen Hepatitis B vaccine HLA DRB1 antigen Influenza vaccine Measles vaccine Mumps vaccine Tumor necrosis factor HLA DRB1 antigen Vaccine Ankylosing spondylitis Article Autoimmune disease Autoimmune thyroiditis Autoimmunity Cytomegalovirus infection Epstein Barr virus infection Ethnicity Gene Genetic polymorphism Genetic risk Graves disease Guillain Barre syndrome Hashimoto disease Hepatitis B Hepatitis C HLA DRB1 gene Human Immune response Infection Insulin dependent diabetes mellitus Major histocompatibility complex Multiple sclerosis Myositis Nonhuman Priority journal Psoriatic arthritis Rheumatoid arthritis Sjoegren syndrome Spondylarthritis Systemic lupus erythematosus Vaccination Animal Autoimmunity Genetics Animals Autoimmune Diseases Autoimmunity HLA-DRB1 Chains Humans Vaccines Autoimmunity DRB1 Gene Genetic HLA system Infections Locus Vaccines Genetic Polymorphism |
| spellingShingle |
Hepatitis B surface antigen Hepatitis B vaccine HLA DRB1 antigen Influenza vaccine Measles vaccine Mumps vaccine Tumor necrosis factor HLA DRB1 antigen Vaccine Ankylosing spondylitis Article Autoimmune disease Autoimmune thyroiditis Autoimmunity Cytomegalovirus infection Epstein Barr virus infection Ethnicity Gene Genetic polymorphism Genetic risk Graves disease Guillain Barre syndrome Hashimoto disease Hepatitis B Hepatitis C HLA DRB1 gene Human Immune response Infection Insulin dependent diabetes mellitus Major histocompatibility complex Multiple sclerosis Myositis Nonhuman Priority journal Psoriatic arthritis Rheumatoid arthritis Sjoegren syndrome Spondylarthritis Systemic lupus erythematosus Vaccination Animal Autoimmunity Genetics Animals Autoimmune Diseases Autoimmunity HLA-DRB1 Chains Humans Vaccines Autoimmunity DRB1 Gene Genetic HLA system Infections Locus Vaccines Genetic Polymorphism Arango M.-T. Perricone C. Kivity S. Cipriano E. Ceccarelli F. Valesini G. Shoenfeld Y. HLA-DRB1 the notorious gene in the mosaic of autoimmunity |
| description |
The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against pathogens and strongly implicated in the development of autoimmune diseases. Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines. It is possible that the interaction of specific HLA with pathogenic antigens is one of the keys favoring (or protecting) toward the development of an autoimmune disease. In the era of personalized medicine, it would be of great help to build a map of the genomic risk of each individual to evaluate the risk of developing an autoimmune condition. © 2016, Springer Science+Business Media New York. |
| format |
Artículo (Article) |
| author |
Arango M.-T. Perricone C. Kivity S. Cipriano E. Ceccarelli F. Valesini G. Shoenfeld Y. |
| author_facet |
Arango M.-T. Perricone C. Kivity S. Cipriano E. Ceccarelli F. Valesini G. Shoenfeld Y. |
| author_sort |
Arango M.-T. |
| title |
HLA-DRB1 the notorious gene in the mosaic of autoimmunity |
| title_short |
HLA-DRB1 the notorious gene in the mosaic of autoimmunity |
| title_full |
HLA-DRB1 the notorious gene in the mosaic of autoimmunity |
| title_fullStr |
HLA-DRB1 the notorious gene in the mosaic of autoimmunity |
| title_full_unstemmed |
HLA-DRB1 the notorious gene in the mosaic of autoimmunity |
| title_sort |
hla-drb1 the notorious gene in the mosaic of autoimmunity |
| publisher |
Humana Press Inc. |
| publishDate |
2017 |
| url |
https://repository.urosario.edu.co/handle/10336/24281 https://doi.org/10.1007/s12026-016-8817-7 |
| _version_ |
1740172990886182912 |
| score |
12,131701 |