Mutant GNLY is linked to Stevens–Johnson syndrome and toxic epidermal necrolysis

"Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions to drugs. Granulysin (GNLY) plays a key role in keratinocyte apoptosis during SJS/TEN pathophysiology. To determine if GNLY-encoding mutations might be related to the protein’s funct...

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Detalles Bibliográficos
Autores Principales: Fonseca-Mendoza, Dora Janeth, Caro L.A., Sierra-Díaz D.C., Serrano-Reyes C., Londoño O., Suárez Y.C., Mateus H.E., Bolívar-Salazar D., Ramírez A.F., de-la-Torre, Alejandra, Laissue P.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Springer 2019
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24215
https://doi.org/10.1007/s00439-019-02066-w