High mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemala
Histoplasmosis is one of the most common and deadly opportunistic infections among persons living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome in Latin America, but due to limited diagnostic capacity in this region, few data on the burden and clinical characteristics o...
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| Formato: | Artículo (Article) |
| Lenguaje: | Inglés (English) |
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American Society of Tropical Medicine and Hygiene
2017
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| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/24207 https://doi.org/10.4269/ajtmh.16-0009 |
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ir-10336-242072022-05-02T12:37:14Z High mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemala Samayoa, Blanca Roy, Monika Cleveland, Angela Ahlquist Medina, Narda Lau-Bonilla, Dalia Scheel, Christina M Chiller, Tom Arathoon, Eduardo Gómez Giraldo, Beatríz Lucia Amphotericin B Antiretrovirus agent Fluconazole Itraconazole Acquired immune deficiency syndrome Ajellomyces capsulatus Antifungal therapy Antiretroviral therapy Article Clinical feature Cohort analysis Guatemala Histoplasmosis Human Human immunodeficiency virus infection Infection sensitivity Median survival time Medical history Mixed infection Mortality Mycobacteriosis Prospective study Acquired immune deficiency syndrome Adult Aged AIDS related complex Cause of death Complication Female Histoplasma Histoplasmosis Human immunodeficiency virus infection Isolation and purification Male Middle aged Mixed infection Mortality Survival Very elderly Young adult Acquired Immunodeficiency Syndrome Adult Aged Aged, 80 and over AIDS-Related Opportunistic Infections Cause of Death Cohort Studies Coinfection Female Guatemala Histoplasma Histoplasmosis HIV Infections Humans Male Middle Aged Mortality Prospective Studies Survival Young Adult Histoplasmosis is one of the most common and deadly opportunistic infections among persons living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome in Latin America, but due to limited diagnostic capacity in this region, few data on the burden and clinical characteristics of this disease exist. Between 2005 and 2009, we enrolled patients 18 years of age with suspected histoplasmosis at a hospital-based HIV clinic in Guatemala City. A case of suspected histoplasmosis was defined as a person presenting with at least three of five clinical or radiologic criteria. A confirmed case of histoplasmosis was defined as a person with a positive culture or urine antigen test for Histoplasma capsulatum. Demographic and clinical data were also collected and analyzed. Of 263 enrolled as suspected cases of histoplasmosis, 101 (38.4%) were confirmed cases. Median time to diagnosis was 15 days after presentation (interquartile range [IQR] = 5-23). Crude overall mortality was 43.6%; median survival time was 19 days (IQR = 4-69). Mycobacterial infection was diagnosed in 70 (26.6%) cases; 26 (25.7%) histoplasmosis cases were coinfected with mycobacteria. High mortality and short survival time after initial symptoms were observed in patients with histoplasmosis. Mycobacterial coinfection diagnoses were frequent, highlighting the importance of pursuing diagnoses for both diseases. and copy; 2017 by The American Society of Tropical Medicine and Hygiene. 2017 2020-05-26T00:10:06Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 29637 https://repository.urosario.edu.co/handle/10336/24207 https://doi.org/10.4269/ajtmh.16-0009 eng info:eu-repo/semantics/openAccess application/pdf American Society of Tropical Medicine and Hygiene instname:Universidad del Rosario |
| institution |
EdocUR - Universidad del Rosario |
| collection |
DSpace |
| language |
Inglés (English) |
| topic |
Amphotericin B Antiretrovirus agent Fluconazole Itraconazole Acquired immune deficiency syndrome Ajellomyces capsulatus Antifungal therapy Antiretroviral therapy Article Clinical feature Cohort analysis Guatemala Histoplasmosis Human Human immunodeficiency virus infection Infection sensitivity Median survival time Medical history Mixed infection Mortality Mycobacteriosis Prospective study Acquired immune deficiency syndrome Adult Aged AIDS related complex Cause of death Complication Female Histoplasma Histoplasmosis Human immunodeficiency virus infection Isolation and purification Male Middle aged Mixed infection Mortality Survival Very elderly Young adult Acquired Immunodeficiency Syndrome Adult Aged Aged, 80 and over AIDS-Related Opportunistic Infections Cause of Death Cohort Studies Coinfection Female Guatemala Histoplasma Histoplasmosis HIV Infections Humans Male Middle Aged Mortality Prospective Studies Survival Young Adult |
| spellingShingle |
Amphotericin B Antiretrovirus agent Fluconazole Itraconazole Acquired immune deficiency syndrome Ajellomyces capsulatus Antifungal therapy Antiretroviral therapy Article Clinical feature Cohort analysis Guatemala Histoplasmosis Human Human immunodeficiency virus infection Infection sensitivity Median survival time Medical history Mixed infection Mortality Mycobacteriosis Prospective study Acquired immune deficiency syndrome Adult Aged AIDS related complex Cause of death Complication Female Histoplasma Histoplasmosis Human immunodeficiency virus infection Isolation and purification Male Middle aged Mixed infection Mortality Survival Very elderly Young adult Acquired Immunodeficiency Syndrome Adult Aged Aged, 80 and over AIDS-Related Opportunistic Infections Cause of Death Cohort Studies Coinfection Female Guatemala Histoplasma Histoplasmosis HIV Infections Humans Male Middle Aged Mortality Prospective Studies Survival Young Adult Samayoa, Blanca Roy, Monika Cleveland, Angela Ahlquist Medina, Narda Lau-Bonilla, Dalia Scheel, Christina M Chiller, Tom Arathoon, Eduardo Gómez Giraldo, Beatríz Lucia High mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemala |
| description |
Histoplasmosis is one of the most common and deadly opportunistic infections among persons living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome in Latin America, but due to limited diagnostic capacity in this region, few data on the burden and clinical characteristics of this disease exist. Between 2005 and 2009, we enrolled patients 18 years of age with suspected histoplasmosis at a hospital-based HIV clinic in Guatemala City. A case of suspected histoplasmosis was defined as a person presenting with at least three of five clinical or radiologic criteria. A confirmed case of histoplasmosis was defined as a person with a positive culture or urine antigen test for Histoplasma capsulatum. Demographic and clinical data were also collected and analyzed. Of 263 enrolled as suspected cases of histoplasmosis, 101 (38.4%) were confirmed cases. Median time to diagnosis was 15 days after presentation (interquartile range [IQR] = 5-23). Crude overall mortality was 43.6%; median survival time was 19 days (IQR = 4-69). Mycobacterial infection was diagnosed in 70 (26.6%) cases; 26 (25.7%) histoplasmosis cases were coinfected with mycobacteria. High mortality and short survival time after initial symptoms were observed in patients with histoplasmosis. Mycobacterial coinfection diagnoses were frequent, highlighting the importance of pursuing diagnoses for both diseases. and copy; 2017 by The American Society of Tropical Medicine and Hygiene. |
| format |
Artículo (Article) |
| author |
Samayoa, Blanca Roy, Monika Cleveland, Angela Ahlquist Medina, Narda Lau-Bonilla, Dalia Scheel, Christina M Chiller, Tom Arathoon, Eduardo Gómez Giraldo, Beatríz Lucia |
| author_facet |
Samayoa, Blanca Roy, Monika Cleveland, Angela Ahlquist Medina, Narda Lau-Bonilla, Dalia Scheel, Christina M Chiller, Tom Arathoon, Eduardo Gómez Giraldo, Beatríz Lucia |
| author_sort |
Samayoa, Blanca |
| title |
High mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemala |
| title_short |
High mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemala |
| title_full |
High mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemala |
| title_fullStr |
High mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemala |
| title_full_unstemmed |
High mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemala |
| title_sort |
high mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in guatemala |
| publisher |
American Society of Tropical Medicine and Hygiene |
| publishDate |
2017 |
| url |
https://repository.urosario.edu.co/handle/10336/24207 https://doi.org/10.4269/ajtmh.16-0009 |
| _version_ |
1740172368975757312 |
| score |
12,131701 |