The H3K9 methylation writer SETDB1 and its reader MPP8 cooperate to silence satellite DNA repeats in mouse embryonic stem cells

SETDB1 (SET Domain Bifurcated histone lysine methyltransferase 1) is a key lysine methyltransferase (KMT) required in embryonic stem cells (ESCs), where it silences transposable elements and DNA repeats via histone H3 lysine 9 tri-methylation (H3K9me3), independently of DNA methylation. The H3K9 met...

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Detalles Bibliográficos
Autores Principales: Cruz-Tapias, Paola, Robin, Philippe, Pontis, Julien, Del Maestro, Laurence, Ait-Si-Ali, Slimane
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: MDPI AG 2019
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