Lupus risk variant increases pSTAT1 binding and decreases ETS1 expression

"Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have been associated with systemic lupus erythematosus (SLE), or lupus, in independent cohorts of Asian ancestry. Several recent studies have implicated ETS1 as a critical driver of immune cell function and differentiation, an...

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Autores Principales: "Lu, Xiaoming, Zoller, Erin E., Weirauch, Matthew T., Wu, Zhiguo, Namjou, Bahram, Williams, Adrienne H., Ziegler, Julie T., Comeau, Mary E., Marion, Miranda C., Glenn, Stuart B., Adler, Adam, Shen, Nan, Nath, Swapan K., Stevens, Anne M., Freedman, Barry I., Tsao, Betty P., Jacob, Chaim O., Kamen, Diane L., Brown, Elizabeth E., Gilkeson, Gary S., Alarcón, Graciela S., Reveille, John D., Anaya, Juan-Manuel, James, Judith A., Sivils, Kathy L., Criswell, Lindsey A., Vilá, Luis M., Alarcón-Riquelme, Marta E., Petri, Michelle, Scofield, R. Hal, Kimberly, Robert P., Ramsey-Goldman, Rosalind, Bin Joo, Young, Choi, Jeongim, Bae, Sang-Cheol, Boackle, Susan A., Graham, Deborah Cunninghame, Vyse, Timothy J., Guthridge, Joel M., Gaffney, Patrick M., Langefeld, Carl D., Kelly, Jennifer A., Greis, Kenneth D., Kaufman, Kenneth M., Harley, John B., Kottyan, Leah C."
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Cell Press 2015
Materias:
Mus
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24141
https://doi.org/10.1016/j.ajhg.2015.03.002