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Genetic association of CD247 (CD3?) with SLE in a large-scale multiethnic study

A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3? chain that alters T-cell receptor signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3? are not well established and require replication in indepe...

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Detalles Bibliográficos
Autores Principales: Martins, M, Williams, A H, Comeau, M, Marion, M, Ziegler, J T, Freedman, B I, Merrill, J T, Glenn, S B, Kelly, J A, Sivils, K M, James, J A, Guthridge, J M, Alarcón-Riquelme, M E, Bae, S-C, Kim, J-H, Kim, D, Anaya, Juan-Manuel, Boackle, S A, Criswell, L A, Kimberly, R P, Alarcón, G S, Brown, E E, Vilá, L M, Petri, M A, Ramsey-Goldman, R, Niewold, T B, Tsao, B P, Gilkeson, G S, Kamen, D L, Jacob, C O, Stevens, A M, Gaffney, P M, Harley, J B, Langefeld, C D, Fesel, C
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Nature Publishing Group 2015
Materias:
CD247 antigen
T lymphocyte antigen
Unclassified drug
CD3 antigen
Adult
African
American Indian
Article
Asian
Chromosome 1
Controlled study
Ethnic difference
European
Female
Gene frequency
Gene locus
Genetic association
Genetic model
Genetic variability
Genotype
Haplotype
Haplotype map
Heterozygosity
Hispanic
Human
Immunopathogenesis
Major clinical study
Male
Molecular pathology
Priority journal
Single nucleotide polymorphism
Systemic lupus erythematosus
Asian continental ancestry group
Case control study
Caucasian
Ethnology
Genetic association study
Genetic predisposition
Genetics
Immunology
T lymphocyte
Asian Continental Ancestry Group
Case-Control Studies
European Continental Ancestry Group
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
Humans
T-Lymphocytes
CD3
Single Nucleotide
zeta chain
Systemic
Antigens
Lupus Erythematosus
Polymorphism
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24137
https://doi.org/10.1038/gene.2014.73

Internet

https://repository.urosario.edu.co/handle/10336/24137
https://doi.org/10.1038/gene.2014.73

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