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A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies manifesting in inflammation of target organs such as the kidneys, skin and joints. Genome-wide association studies have identified genetic va...

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Detalles Bibliográficos
Autores Principales: Wang, S, Adrianto, I, Wiley, G B, Lessard, C J, Kelly, J A, Adler, A J, Glenn, S B, Williams, A H, Ziegler, J T, Comeau, M E, Marion, M C, Wakeland, B E, Liang, C, Kaufman, K M, Guthridge, J M, Alarcón-Riquelme, M E, Alarcón, G S, Anaya, Juan-Manuel, Bae, S-C, Kim, J-H, Joo, Y B, Boackle, S A, Brown, E E, Petri, M A, Ramsey-Goldman, R, Reveille, J D, Vilá, L M, Criswell, L A, Edberg, J C, Freedman, B I, Gilkeson, G S, Jacob, C O, James, J A, Kamen, D L, Kimberly, R P, Martin, J, Merrill, J T, Niewold, T B, Pons-Estel, B A, Scofield, R H, Stevens, A M, Tsao, B P, Vyse, T J, Langefeld, C D, Harley, J B, Wakeland, E K, Moser, K L, Montgomery, C G, Gaffney, P M
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2012
Materias:
Messenger RNA
UBE2L3 protein
Ubiquitin
Ubiquitin conjugating enzyme
Unclassified drug
Article
Autoimmunity
Female
Gene expression
Genetic analysis
Genetic association
Haplotype
Human
Major clinical study
Male
Priority journal
Risk assessment
Systemic lupus erythematosus
African Americans
Alleles
Asian Continental Ancestry Group
European Continental Ancestry Group
Genetic Predisposition to Disease
Haplotypes
Hispanic Americans
Humans
Linkage Disequilibrium
Ubiquitin-Conjugating Enzymes
Multi-ethnic association study
UBCH7 expression
UBE2L3
Single Nucleotide
Systemic
Lupus Erythematosus
Polymorphism
Acceso en línea:https://repository.urosario.edu.co/handle/10336/24136
https://doi.org/10.1038/gene.2012.6

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